2. Signaling Pathways
  3. GPCR/G Protein
    Immunology/Inflammation
  4. CCR
  5. CCR Antagonist

CCR Antagonist

CCR Isoform Comparison

CCR Antagonists (105):

Cat. No. Product Name Effect Purity
  • HY-P4191A
    Met-RANTES (human) (acetate)
    		Antagonist 99.62%
    Met-RANTES (human) acetate is the acetate form of Met-RANTES (human) (HY-P4191). Met-RANTES (human) acetate is the antagonist for CCR1 and CCR5. Met-RANTES (human) acetate inhibits chemokines human MIP-1α and MIP-1β with IC50 of 5 and 2 nM. Met-RANTES (human) acetate reduces bone destruction and ameliorates rats adjuvant-induced arthritis (AIA).
  • HY-12944
    GSK163929
    		Antagonist
    GSK163929 (compound 122) is an orally active, anti-HIV CCR5 antagonist with low inhibitory potency against hEGR. GSK163929 had no adverse effects in rats at 2000 mg/kg/day (i.v., 7 d) and in dogs at 250 mg/kg/day (i.v., 7 d).
  • HY-111037
    BMS-457
    		Antagonist
    BMS-457 is a potent and selective CCR1 antagonist. BMS-457 can be used in the study of rheumatoid arthritis.
  • HY-160658
    AZ760
    		Antagonist
    AZ760 is a CCR8 antagonist. AZ760 shows excellent potency, good lipophilicity and high free fraction in blood. AZ760 exhibits unacceptable hERG inhibition.
  • HY-123270
    RP23618
    		Antagonist
    RP23618 is a non peptidic RANTES antagonist with the IC50 of 3 μM. RP23618 inhibit RANTES-induced chemotaxis of THP-1 cells.