2. Signaling Pathways
  3. Cytoskeleton
  4. Collagen

Collagen

Collagen

Collagens are the most abundant proteins in mammals. The collagen family comprises 28 members that contain at least one triple-helical domain. Beyond the existence of 28 collagen types, further diversity occurs in the collagen family because of the existence of several molecular isoforms for the same collagen type (e.g., collagens IV and VI) and of hybrid isoforms comprised of a chains belonging to two different collagen types (type V/XI molecules). Collagens are deposited in the extracellular matrix where most of them form supramolecular assemblies. Four collagens are type II membrane proteins that also exist in a soluble form released from the cell surface by shedding. Collagens play structural roles and contribute to mechanical properties, organization, and shape of tissues. They interact with cells via several receptor families and regulate their proliferation, migration, and differentiation[1].

Collagen Related Products (9):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-108681
    680C91
    		Inhibitor 99.54%
    680C91 is an orally active, selective tryptophan 2,3-dioxygenase (TDO) inhibitor with a Ki of 51 nM. TDO is the key enzyme of tryptophan catabolism. 680C91 can be used for the research of cancer immunotherapy and Alzheimer’s Disease.
    680C91
  • HY-P0045
    Palmitoyl pentapeptide 4
    		Inducer 99.58%
    Palmitoyl pentapeptide 4 (Matrixyl; Palmitoyl pentapeptide 3; Matrixyl (Palmitoyl Pentapeptide) is a bioactive peptide with anti-ageing effect and has been reported used as a cosmetic ingredient[1]
    Palmitoyl pentapeptide 4
  • HY-W014075
    1-Hydroxypyrene
    		Activator 99.84%
    1-Hydroxypyrene, a biomarker of exposure to polycyclic aromatic hydrocarbons (PAHs), is analyzed in urine samples. 1-Hydroxypyrene is the major biomarker of exposure to pyrenes. 1-Hydroxypyrene is the orally active agonist for aryl hydrocarbon receptor (AhR) and can lead to renal fibrosis.
    1-Hydroxypyrene
  • HY-29035
    Dopamine acrylamide
    		98.39%
    Dopamine acrylamide, a polyphenol derivative, can cross-link collagen mainly via noncovalent bonding under acidic-non-oxidized conditions.
    Dopamine acrylamide
  • HY-N2589
    Isosaponarin
    		Inducer 99.59%
    Isosaponarin is a flavone glycoside isolated from wasabi leaves. Isosaponarin is a P4HA2 enzymatic agonist. Isosaponarin increases collagen synthesis via up-regulated TGF-β type II receptor (TβR-II) and prolyl 4-hydroxylase (P4H) proteins production, promoting skin health and wound healing. Isosaponarin-rich plants exhibit strong antimicrobial, antioxidant, anti-hyaluronidase, antiplatelet, anti-atopic dermatitis, and anti-tumor effects.
    Isosaponarin
  • HY-131577A
    Neutral protease I
    Neutral protease I (Dispase I) is a rapid, effective, gentle and neutral protease that can separate intact epidermis from the dermis. Neutral protease I can also separate intact epithelial sheets in culture from the substratum. Neutral protease I preserves the viability of the epithelial cells while cleaving the basement membrane zone region. Neutral protease I can also be used to prevent clumping in suspension cultures. Neutral protease I cleaves fibronectin and type IV collagen, but not laminin, type V collagen, serum albumin, or transferrin.
    Neutral protease I
  • HY-P10904
    Vezocolmitide
    Vezocolmitide is a collagen mimetic peptide and is the component of ST-100. Vezocolmitide can be used for research of dry eye disease (DED).
    Vezocolmitide
  • HY-127150
    Clofezone
    		Inhibitor
    Clofezone (Perclusone) is an antirheumatic agent that inhibits collagen formation in rat Chondrus granulomas. Clofezone can be used in the study of various rheumatic diseases, especially arthritis (RA) and ankylosing spondylitis (AS).
    Clofezone
  • HY-W273690
    Pentifylline
    		Inhibitor
    Pentifylline is a vasodilator with anti-inflammatory activity. Pentifylline inhibits platelet aggregation and thromboxane A2 synthesis, reduces the release of free radicals, and decreases the production of type 1 collagen and laminin in fibroblasts. Pentifylline has the potential to be studied in acute ischemic stroke.
    Pentifylline