2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Drug Metabolite

Drug Metabolite

Drug Metabolite

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Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-114686
    (R)-γ-Valerolactone
    (R)-γ-Valerolactone is a precursor of antihypertensive compounds. (R)-γ-Valerolactone can also be used in the research of biodegradable plastics and biofuels.
    (R)-γ-Valerolactone
  • HY-128669R
    Abemaciclib metabolite M2 (Standard)
    Abemaciclib metabolite M2 (Standard)
  • HY-129443
    Deacetylcephaloglycin
    Deacetylcephaloglycin is the active metabolite of Cephaloglycin (HY-16137). Deacetylcephaloglycin is a degradation product of Cephaloglycin that eliminates the 3-acetyl group in acidic medium and can be further degraded to Deacetylcephaloglycin lactone. Deacetylation is the rate-determining step in the degradation of Cephaloglycin to lactone.
    Deacetylcephaloglycin
  • HY-G0010
    Netupitant metabolite N-desmethyl Netupitant
    N-desmethyl Netupitant is a metabolite of Netupitant, which is an antiemitic drug.
    Netupitant metabolite N-desmethyl Netupitant
  • HY-168354
    Desmethylflutiazepam
    Desmethylflutiazepam (N-Desmethylfludiazepam) is a metabolite of various benzodiazepine compounds.
    Desmethylflutiazepam
  • HY-119223
    Desmethylmirtazapine
    Desmethylmirtazapine is an active metabolite of Mirtazapine that has antidepressant effects.
    Desmethylmirtazapine
  • HY-163038
    Sulfamethoxazole-NO hydrate
    Sulfamethoxazole-NO (SMX-NO) hydrate is the reactive metabolite of SMX (HY-B0322). Sulfamethoxazole-NO (SMX-NO) hydrate actis as a typical hapten and is capable of covalently modifying the MHC-peptide complex, can stimulate hapten-reactive T cells.
    Sulfamethoxazole-NO hydrate
  • HY-N8341
    Alphitonin
    		Control
    Alphitonin is a flavonoid and is also a metabolic intermediate that is formed during the catabolism of Quercetin (HY-18085) by the human gut bacteria E. ramulus.
    Alphitonin
  • HY-169330
    3β,5α,6β-Trihydroxycholanic acid
    3β,5α,6β-Trihydroxycholanic acid is a metabolite of 3β,5α,6β-Trihydroxycholestane (HY-W010934). 3β,5α,6β-Trihydroxycholanic acid can be used in research related to neurodegenerative diseases associated with lysosomal dysfunction.
    3β,5α,6β-Trihydroxycholanic acid
  • HY-126857R
    5-Hydroxyomeprazole (Standard)
    5-Hydroxyomeprazole (Standard) is the analytical standard of 5-Hydroxyomeprazole. This product is intended for research and analytical applications. 5-Hydroxyomeprazole is the major metabolite of Omeprazole (HY-B0113).
    5-Hydroxyomeprazole (Standard)
  • HY-G0002
    Lurasidone metabolite 14326
    		Chemical
    Lurasidone metabolite 14326 is an active metabolite of the atypical antipsychotic Lurasidone.
    Lurasidone metabolite 14326
  • HY-114992
    2-Propyl-2-pentenoic acid
    2-Propyl-2-pentenoic acid is a metabolite of Valproic acid (HY-10585). 2-Propyl-2-pentenoic acid has a facilitating action on the acquisition of conditioned behavior with negative reinforcement in mice.
    2-Propyl-2-pentenoic acid
  • HY-116029
    Tolmetin β-D-Glucuronide
    Tolmetin β-D-Glucuronide (Tolmetin glucuronide) is the major phase II metabolite of Tolmetin (HY-B1799).
    Tolmetin β-D-Glucuronide
  • HY-148083
    TBBPA-sulfate
    TBBPA-sulfate is metabolite of TBBPA. TBBPA has been reported to enhance adipogenesis by binding with the peroxisome proliferator-activated receptor gamma (PPARγ).
    TBBPA-sulfate
  • HY-G0014S
    Quetiapine Sulfoxide-d8
    Quetiapine Sulfoxide-d8 is the deuterium labeled Quetiapine sulfoxide. Quetiapine sulfoxide (Quetiapine S-oxide) is a main metabolite of Quetiapinem. Quetiapine is a second-generation antipsychotic[1]. Quetiapine is a 5-HT receptors agonist and a dopamine receptor antagonist[1][2].
    Quetiapine Sulfoxide-d<sub>8</sub>
  • HY-138128
    Acetaminophen mercapturate
    Acetaminophen mercapturate is a metabolite of Acetaminophen. Acetaminophen is a selective COX-2 inhibitor.
    Acetaminophen mercapturate
  • HY-W724091
    PB-22 N-pentanoic acid metabolite
    		Control
    PB-22 N-pentanoic acid metabolite is a metabolite of PB-22. PB-22 is a cannabinoid.
    PB-22 N-pentanoic acid metabolite
  • HY-W700620
    Hydroxymethyl dasatinib
    		99.92%
    Hydroxymethyl dasatinib (M24), a benzylhydroxy metabolite of Dasatinib (HY-10181), exhibits an IC50 of 46.7nM in K562 CML cells.
    Hydroxymethyl dasatinib
  • HY-I0678R
    Regorafénib N-oxyde (M2) (Standard)
    Quinocetone (Standard) is the analytical standard of Quinocetone. This product is intended for research and analytical applications. Quinocetone is a potent synthetic antimicrobial agent that is used for improving the feed efficiency and controlling dysentery in food-producing animals.
    Regorafénib N-oxyde (M2) (Standard)
  • HY-13318R
    Oseltamivir acid (Standard)
    Oseltamivir acid (Standard) is the analytical standard of Oseltamivir acid. This product is intended for research and analytical applications. Oseltamivir acid (GS 4071), the active metabolite of Oseltamivir phosphate, is an orally bioavailable, potent and selective inhibitor of influenza virus neuraminidase (IC50=2 nM) with activity against both influenza A and B viruses.
    Oseltamivir acid (Standard)
Cat. No. Product Name / Synonyms Application Reactivity