Hydroxymethyl dasatinib

Cat. No.: HY-W700620 Purity: 99.92%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Hydroxymethyl dasatinib (M24), a benzylhydroxy metabolite of Dasatinib (HY-10181), exhibits an IC₅₀ of 46.7nM in K562 CML cells.

For research use only. We do not sell to patients.

Hydroxymethyl dasatinib Chemical Structure

CAS No. : 910297-58-4

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

or Bulk Inquiry

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

View All Src Isoform Specific Products:

View All Isoforms

Lck Fyn Blk

Biological Activity
Purity & Documentation
References
Customer Review

Description

Hydroxymethyl dasatinib (M24), a benzylhydroxy metabolite of Dasatinib (HY-10181), exhibits an IC₅₀ of 46.7nM in K562 CML cells^[1].

Molecular Weight

504.00

Formula

C₂₂H₂₆ClN₇O₃S

CAS No.

910297-58-4

Appearance

Solid

Color

White to light yellow

SMILES

O=C(NC1=C(C=CC=C1Cl)CO)C2=CN=C(S2)NC3=CC(N4CCN(CC4)CCO)=NC(C)=N3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (248.02 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.9841 mL	9.9206 mL	19.8413 mL
5 mM	0.3968 mL	1.9841 mL	3.9683 mL
10 mM	0.1984 mL	0.9921 mL	1.9841 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.92%

Select Batch:

Data Sheet (268 KB) SDS (784 KB)

COA (249 KB) HNMR (477 KB) LCMS (94 KB)

Handling Instructions (2659 KB)

References

[1]. Lisa J Christopher, et al. Metabolism and disposition of dasatinib after oral administration to humans. Drug Metab Dispos. 2008 Jul;36(7):1357-64. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.9841 mL	9.9206 mL	19.8413 mL	49.6032 mL
	5 mM	0.3968 mL	1.9841 mL	3.9683 mL	9.9206 mL
	10 mM	0.1984 mL	0.9921 mL	1.9841 mL	4.9603 mL
	15 mM	0.1323 mL	0.6614 mL	1.3228 mL	3.3069 mL
	20 mM	0.0992 mL	0.4960 mL	0.9921 mL	2.4802 mL
	25 mM	0.0794 mL	0.3968 mL	0.7937 mL	1.9841 mL
	30 mM	0.0661 mL	0.3307 mL	0.6614 mL	1.6534 mL
	40 mM	0.0496 mL	0.2480 mL	0.4960 mL	1.2401 mL
	50 mM	0.0397 mL	0.1984 mL	0.3968 mL	0.9921 mL
	60 mM	0.0331 mL	0.1653 mL	0.3307 mL	0.8267 mL
	80 mM	0.0248 mL	0.1240 mL	0.2480 mL	0.6200 mL
	100 mM	0.0198 mL	0.0992 mL	0.1984 mL	0.4960 mL