2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Glycosidase

Glycosidase

Glycosidase

Glycosidase

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Glycosidase are a class of enzymes which catalyze the hydrolysis of glycosidic bonds. In living organisms, Glycosidase are involved in carbohydrate metabolism. They can degrade polysaccharides such as starch and glycogen into monosaccharides, providing energy for cells. Glycosidase also participate in the synthesis and modification of biological macromolecules such as glycoproteins and glycolipids, playing a crucial role in cell recognition and signal transduction. Additionally, in plants and microorganisms, Glycosidase are involved in the metabolism of cell wall polysaccharide components, affecting cell growth, differentiation, and morphogenesis. Gene mutations of Glycosidase can trigger genetic diseases, leading to abnormal metabolism in the body and damage to organ functions. Changes in their activity are associated with various diseases such as diabetes, infectious diseases, and tumors, and can influence the occurrence and development of diseases[1][2].

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-N7626
    Eleutherol
    		Inhibitor 99.94%
    Eleutherol is a naphthalene isolated from E. americana with antifungal activities. Eleutherol is against yeasts Candida albicans, C. tropicalis, Saccharomyces cerevisiae and Cryptococcus neoformans with MIC values between 7.8 µg/mL and 250 µg/mL. Eleutherol inhibits α-glucosidase function with an IC50>1.00 mM.
    Eleutherol
  • HY-N4258
    Panasenoside
    		Inhibitor 99.93%
    Panasenoside is a flavonoid isolated from Lilium pumilum DC. Panasenoside exhibits α-glucosidase inhibitory activity.
    Panasenoside
  • HY-126362
    ML266
    		Activator 99.70%
    ML266 is glucocerebrosidase (GCase) molecule chaperone with IC50 of 2.5 µM. ML266 binds to GCase and transports of the mutant protein to the lysosome, and resume the activity of GCase. ML266 dose not inhibit the GCase enzyme’s action. ML266 has the potential for the research of gaucher disease.
    ML266
  • HY-N8517
    Malabaricone B
    		Inhibitor 99.58%
    Malabaricone B, a naturally occurring plant phenolic, is an orally active α-glucosidase inhibitor with an IC50 of 63.7 µM. Malabaricone B has anticancer, antimicrobial, anti-oxidation and antidiabetic activities.
    Malabaricone B
  • HY-N2821
    (+)-Afzelechin
    		Inhibitor ≥98.0%
    (+)-Afzelechin, isolated from rhizomes of Bergenia ligulata, is an alpha-glucosidase activity inhibitor with an ID50 (50% inhibition dose) value of 0.13 mM. (+)-Afzelechin can delay the absorption of carbohydrates in food to suppress postprandial hyperglycemia and hyperinsulinemia.
    (+)-Afzelechin
  • HY-N2223
    Ganoderol B
    		Inhibitor
    Ganoderol B is a potent α-glucosidase inhibitor. Ganoderol B has high α-glucosidase inhibition with an IC50 of 48.5 μg/mL (119.8 μM).
    Ganoderol B
  • HY-N3078
    p-Hydroxyphenethyl trans-ferulate
    		Inhibitor 99.68%
    p-Hydroxyphenethyl trans-ferulate has anti-hyperglycemic (yeast α-glucosidase, IC50=19.24 ± 1.73 µM), antioxidant, and anti-inflammatory activities. p-Hydroxyphenethyl trans-ferulate shows inhibiting anticancer and serotonergic activity.
    p-Hydroxyphenethyl trans-ferulate
  • HY-125713
    Ganoderic acid Y
    		Inhibitor 99.32%
    Ganoderic acid Y is a α-glucosidase inhibitor with an IC50 of 170 μM for yeast α-glucosidase. Ganoderic acid Y inhibits enterovirus 71 (EV71) replication through blocking EV71 uncoating.
    Ganoderic acid Y
  • HY-137490
    4-Methylumbelliferyl α-L-arabinofuranoside
    		99.93%
    4-Methylumbelliferyl α-L-arabinofuranoside is the glycosidase substrate.
    4-Methylumbelliferyl α-L-arabinofuranoside
  • HY-16134
    Celgosivir
    		Inhibitor
    Celgosivir (MBI 3253; MDL 28574; MX3253) is an α-glucosidase I inhibitor; inhibits bovine viral diarrhoea virus (BVDV) with an IC50 of 1.27 μM in in vitro assay.
    Celgosivir
  • HY-U00090
    N-Methylmoranoline
    		Inhibitor ≥99.0%
    N-Methylmoranoline (MOR 14) is an α-glucosidase inhibitor.
    N-Methylmoranoline
  • HY-B1039AS
    Ambroxol-d5 hydrochloride
    		Activator 99.46%
    Ambroxol-d5 (hydrochloride) is the deuterium labeled Ambroxol hydrochloride. Ambroxol hydrochloride (NA-872 hydrochloride), an active metabolite of the proagent Bromhexine, has potent expectorant effects. Ambroxol hydrochloride is a glucocerebrosidase (GCase) chaperone and increases glucocerebrosidase activity. Ambroxol hydrochloride induces lung autophagy and has the potential for Parkinson disease and neuronopathic Gaucher disease research[1][2].
    Ambroxol-d<sub>5</sub> hydrochloride
  • HY-N10002
    Caffeoyltryptophan
    		Inhibitor
    Caffeoyltryptophan is a competitive PTP1B inhibitor, with an IC50 of 16.99 μM. Caffeoyltryptophan can also inhibit α-glucosidase, linoleic acid peroxidation and haemolysis. Caffeoyltryptophan can be used for the research of type 2 diabetes.
    Caffeoyltryptophan
  • HY-163388
    CHI3L1-IN-2
    		Inhibitor
    CHI3L1-IN-2 (Compound 36) is a CHI3L1(YKL-40) inhibitor. CHI3L1-IN-2 inhibits the interaction between CHI3L1 and heparan sulfate (CHI3L1:HSIII), with an IC50 of 26 nM.
    CHI3L1-IN-2
  • HY-N8161
    Kaempferol-3,7-di-O-β-glucoside
    		Inhibitor 99.59%
    Kaempferol-3,7-di-O-β-glucoside (Kaempferol 3,7-diglucoside), a flavonol, possesses enzyme inhibition property towards α-amylase, α-glucosidase and Acetylcholinesterase. Kaempferol-3,7-di-O-β-glucoside protects differentiating neuronal cells, SH-SY5Y from Amyloid β peptide-induced injury. Kaempferol-3,7-di-O-β-glucoside has the potential for Alzheimer's research.
    Kaempferol-3,7-di-O-β-glucoside
  • HY-N3431
    Kaempferol-7-O-rhamnoside
    		Inhibitor ≥99.0%
    Kaempferol-7-O-rhamnoside, isolated from Chimonanthus nitens Oliv. Leaves, is a potent α-glucosidase activity inhibitor. Kaempferol-7-O-rhamnoside has the potential for diabetes.
    Kaempferol-7-O-rhamnoside
  • HY-N7763
    Casuarictin
    		Inhibitor 98.62%
    Casuarictin is a potent and competitive α-glucosidase inhibitor with an IC50 of 0.21 μg/mL. Casuarictin is a presenilin stabilization factor like protein (PSFL) protein inhibitor. Casuarictin can be used for Alzheimer's disease research.
    Casuarictin
  • HY-N2383
    Validamine
    		Inhibitor
    Validamine competitively inhibits β-glucosidase in a pH-dependent and dose-dependent manner, with an IC50 value of 2.92mM, and the maximum inhibitory ability is at the optimum pH value of this enzyme.
    Validamine
  • HY-N10413
    Diphlorethohydroxycarmalol
    		Inhibitor 98.46%
    Diphlorethohydroxycarmalol, a kind of phlorotannin, is an orally active α-glucosidase and α-amylase inhibitor with IC50s of 0.16 mM and 0.53 mM, respectively. Diphlorethohydroxycarmalol has anti-diabetic activities.
    Diphlorethohydroxycarmalol
  • HY-132177B
    α1-2,4,6 Fucosidase O, Omnitrophica bacterium
    α1-2,4,6 Fucosidase O (EC 3.2.1.51) is a broad specificity exoglycosidase that catalyzes the hydrolysis of terminal α1-2, α1-4 and α1-6 linked fucose residues from oligosaccharides, with α1-6 fucose residues more efficiently.
    α1-2,4,6 Fucosidase O, Omnitrophica bacterium
Cat. No. Product Name / Synonyms Application Reactivity