2. Metabolic Enzyme/Protease
  3. Glycosidase
  4. Diphlorethohydroxycarmalol

Diphlorethohydroxycarmalol, a kind of phlorotannin, is an orally active α-glucosidase and α-amylase inhibitor with IC50s of 0.16 mM and 0.53 mM, respectively. Diphlorethohydroxycarmalol has anti-diabetic activities.

For research use only. We do not sell to patients.

Diphlorethohydroxycarmalol Chemical Structure

Diphlorethohydroxycarmalol Chemical Structure

CAS No. : 138529-04-1

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Based on 1 publication(s) in Google Scholar

Diphlorethohydroxycarmalol Related Antibodies

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Description

Diphlorethohydroxycarmalol, a kind of phlorotannin, is an orally active α-glucosidase and α-amylase inhibitor with IC50s of 0.16 mM and 0.53 mM, respectively. Diphlorethohydroxycarmalol has anti-diabetic activities[1].

IC50 & Target

IC50: 0.16 mM (α-glucosidase) and 0.53 mM (α-amylase) [1]
In Vivo

The increase of postprandial blood glucose levels are significantly suppressed in the Diphlorethohydroxycarmalol-administered group than those in the streptozotocin-induced diabetic or normal mice. Moreover, the area under curve (AUC) is significantly reduced via Diphlorethohydroxycarmalol (100 mg/kg; p.o.) administration (2022 versus 2210 mmol x min/lL) in the diabetic mice as well as it delays absorption of dietary carbohydrates[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

512.38

Formula

C24H16O13
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC1=CC(O)=C(OC2=C(O)C(O)=C3OC4=CC(O)=C(OC5=CC(O)=CC(O)=C5)C(O)=C4OC3=C2)C(O)=C1
Structure Classification
Initial Source

Ishige okamurae
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

H2O : 10 mg/mL (19.52 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9517 mL 9.7584 mL 19.5168 mL
5 mM 0.3903 mL 1.9517 mL 3.9034 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.9517 mL 9.7584 mL 19.5168 mL 48.7919 mL
5 mM 0.3903 mL 1.9517 mL 3.9034 mL 9.7584 mL
10 mM 0.1952 mL 0.9758 mL 1.9517 mL 4.8792 mL
15 mM 0.1301 mL 0.6506 mL 1.3011 mL 3.2528 mL
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Diphlorethohydroxycarmalol Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Diphlorethohydroxycarmalol138529-04-1Glycosidasephlorotanninα-glucosidaseα-amylaseanti-diabetic activitiesInhibitorinhibitorinhibit

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