2. Metabolic Enzyme/Protease Apoptosis
  3. Glucosidase Apoptosis
  4. Malabaricone B

Malabaricone B, a naturally occurring plant phenolic, is an orally active α-glucosidase inhibitor with an IC50 of 63.7 µM. Malabaricone B has anticancer, antimicrobial, anti-oxidation and antidiabetic activities.

For research use only. We do not sell to patients.

Malabaricone B Chemical Structure

Malabaricone B Chemical Structure

CAS No. : 63335-24-0

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5 mg USD 290 In-stock
10 mg USD 430 In-stock
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Based on 1 publication(s) in Google Scholar

Malabaricone B Related Antibodies

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Description

Malabaricone B, a naturally occurring plant phenolic, is an orally active α-glucosidase inhibitor with an IC50 of 63.7 µM. Malabaricone B has anticancer, antimicrobial, anti-oxidation and antidiabetic activities[1][2][3].

In Vitro

Malabaricone B shows selective toxicity to human lung cancer (A549), malignant melanoma (A375) and T cell leukemia (Jurkat) cell lines, without showing toxicity to human normal intestinal (INT407), human kidney (HEK293) and lung fibroblast (WI-38) cells. Among the chosen cancer cell lines, Malabaricone B shows maximum cytotoxicity to the A549 cells (IC50 = 8.1 μM), which is significantly better than that of curcumin (IC50 = 26.7 μM)[1].
The Malabaricone B-induced apoptosis is mediated by an increase in the intracellular reactive oxygen species (ROS). Malabaricone B (2.5, 5, 10 and 20 µM) increases the BAX level while simultaneously decreasing the BCL-2 and BCL-XL levels in the A549 cells, triggering the mitochondrial apoptotic pathway as revealed from the release of cytochrome c, and the activation of caspase-9 and caspase-3[1].
Malabaricone B exhibits a good level of antimicrobial activity when tested against avariety of microorganisms, including Staphylococcus aureus and Candida albicans[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Malabaricone B Related Antibodies
In Vivo

Malabaricone B (100 mg/kg; p.o; alternate day, 23 days) inhibits lung tumor (xenograft) growth in SCID mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

342.43

Formula

C21H26O4
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(C1=C(O)C=CC=C1O)CCCCCCCCC2=CC=C(O)C=C2
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (292.03 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9203 mL 14.6015 mL 29.2030 mL
5 mM 0.5841 mL 2.9203 mL 5.8406 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9203 mL 14.6015 mL 29.2030 mL 73.0076 mL
5 mM 0.5841 mL 2.9203 mL 5.8406 mL 14.6015 mL
10 mM 0.2920 mL 1.4602 mL 2.9203 mL 7.3008 mL
15 mM 0.1947 mL 0.9734 mL 1.9469 mL 4.8672 mL
20 mM 0.1460 mL 0.7301 mL 1.4602 mL 3.6504 mL
25 mM 0.1168 mL 0.5841 mL 1.1681 mL 2.9203 mL
30 mM 0.0973 mL 0.4867 mL 0.9734 mL 2.4336 mL
40 mM 0.0730 mL 0.3650 mL 0.7301 mL 1.8252 mL
50 mM 0.0584 mL 0.2920 mL 0.5841 mL 1.4602 mL
60 mM 0.0487 mL 0.2434 mL 0.4867 mL 1.2168 mL
80 mM 0.0365 mL 0.1825 mL 0.3650 mL 0.9126 mL
100 mM 0.0292 mL 0.1460 mL 0.2920 mL 0.7301 mL
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Malabaricone B Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Malabaricone B63335-24-0GlucosidaseApoptosisanticancerantimicrobialanti-oxidationantidiabeticα-glucosidasephenolicInhibitorinhibitorinhibit

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