p-Hydroxyphenethyl trans-ferulate

Cat. No.: HY-N3078 Purity: 99.68%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

p-Hydroxyphenethyl trans-ferulate has anti-hyperglycemic (yeast α-glucosidase, IC₅₀=19.24 ± 1.73 µM), antioxidant, and anti-inflammatory activities. p-Hydroxyphenethyl trans-ferulate shows inhibiting anticancer and serotonergic activity.

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p-Hydroxyphenethyl trans-ferulate Chemical Structure

CAS No. : 84873-15-4

Size	Price	Stock	Quantity
5 mg	USD 275	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 440	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 880	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

p-Hydroxyphenethyl trans-ferulate has anti-hyperglycemic (yeast α-glucosidase, IC₅₀=19.24 ± 1.73 µM), antioxidant, and anti-inflammatory activities^[1]. p-Hydroxyphenethyl trans-ferulate shows inhibiting anticancer and serotonergic activity^[2].

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	IC₅₀	47.6 μM Compound: 5	Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells by liquid scintillation counting Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells by liquid scintillation counting	[PMID: 16643021]
Erythrocyte	IC₅₀	0.66 mM Compound: 26	Anticomplement activity in sheep erythrocytes assessed as concentration required for 50% hemolytic inhibition by classic pathway pretreated for 10 mins with guinea pig serum followed by erythrocyte addition measured after 30 mins by spectrophotometeric me Anticomplement activity in sheep erythrocytes assessed as concentration required for 50% hemolytic inhibition by classic pathway pretreated for 10 mins with guinea pig serum followed by erythrocyte addition measured after 30 mins by spectrophotometeric me	[PMID: 29631958]
Erythrocyte	IC₅₀	1.01 mM Compound: 26	Anticomplement activity in rabbit erythrocytes assessed as concentration required for 50% hemolytic inhibition by alternative pathway pretreated for 10 mins with normal human serum followed by erythrocyte addition measured after 30 mins by spectrophotomet Anticomplement activity in rabbit erythrocytes assessed as concentration required for 50% hemolytic inhibition by alternative pathway pretreated for 10 mins with normal human serum followed by erythrocyte addition measured after 30 mins by spectrophotomet	[PMID: 29631958]
HT-1080	ED₅₀	47.1 μg/mL Compound: f	Antiproliferative activity against human HT1080 cells after 4 days by MTT assay Antiproliferative activity against human HT1080 cells after 4 days by MTT assay	[PMID: 11374950]
MDA-MB-231	IC₅₀	44.3 μM Compound: 5; Tyrosol ferulate	Antimigratory activity against human MDA-MB-231 cells expressing c-MET assessed as inhibition of HGF-induced cell migration incubated for 24 hrs by Giemsa staining based wound healing assay Antimigratory activity against human MDA-MB-231 cells expressing c-MET assessed as inhibition of HGF-induced cell migration incubated for 24 hrs by Giemsa staining based wound healing assay	[PMID: 27258622]
MDA-MB-231	IC₅₀	87.6 μM Compound: 5; Tyrosol ferulate	Antiproliferative activity against human MDA-MB-231 cells expressing c-MET assessed as inhibition of HGF-induced cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells expressing c-MET assessed as inhibition of HGF-induced cell growth incubated for 72 hrs by MTT assay	[PMID: 27258622]
MDA-MB-468	IC₅₀	95.5 μM Compound: 5; Tyrosol ferulate	Antiproliferative activity against human MDA-MB-468 cells expressing c-MET assessed as inhibition of HGF-induced cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against human MDA-MB-468 cells expressing c-MET assessed as inhibition of HGF-induced cell growth incubated for 72 hrs by MTT assay	[PMID: 27258622]

Molecular Weight

314.33

Formula

C₁₈H₁₈O₅

CAS No.

84873-15-4

Appearance

Solid

Color

White to off-white

SMILES

OC(C=C1)=CC=C1CCOC(/C=C/C2=CC(OC)=C(O)C=C2)=O

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (318.14 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.1814 mL	15.9069 mL	31.8137 mL
5 mM	0.6363 mL	3.1814 mL	6.3627 mL
10 mM	0.3181 mL	1.5907 mL	3.1814 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Concentration _(final)

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In Vivo Dissolution Calculator

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Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.68%

Select Batch:

Data Sheet (268 KB) SDS (394 KB)

COA (244 KB) HNMR (137 KB) RP-HPLC (282 KB)

Handling Instructions (2659 KB)

References

[1]. Arciniegas A ,et al. Anti-hyperglycemic, antioxidant, and anti-inflammatory activities of extracts and metabolites from Sida acuta and Sida rhombifolia[J]. Química Nova, 2017, 40(2).

[2]. Park H Y , et al. Constituents of the Stem of Angelica gigas with Rat Lens Aldose Reductase Inhibitory Activity[J]. Journal of the Korean Society for Applied Biological Chemistry, 2011, 54(2):194-199.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.1814 mL	15.9069 mL	31.8137 mL	79.5343 mL
	5 mM	0.6363 mL	3.1814 mL	6.3627 mL	15.9069 mL
	10 mM	0.3181 mL	1.5907 mL	3.1814 mL	7.9534 mL
	15 mM	0.2121 mL	1.0605 mL	2.1209 mL	5.3023 mL
	20 mM	0.1591 mL	0.7953 mL	1.5907 mL	3.9767 mL
	25 mM	0.1273 mL	0.6363 mL	1.2725 mL	3.1814 mL
	30 mM	0.1060 mL	0.5302 mL	1.0605 mL	2.6511 mL
	40 mM	0.0795 mL	0.3977 mL	0.7953 mL	1.9884 mL
	50 mM	0.0636 mL	0.3181 mL	0.6363 mL	1.5907 mL
	60 mM	0.0530 mL	0.2651 mL	0.5302 mL	1.3256 mL
	80 mM	0.0398 mL	0.1988 mL	0.3977 mL	0.9942 mL
	100 mM	0.0318 mL	0.1591 mL	0.3181 mL	0.7953 mL