2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Endogenous Metabolite

Endogenous Metabolite

Endogenous Metabolite

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Metabolite results when a drug is metabolized into a modified form which continues to produce effects. A metabolome in a given body fluid is influenced by endogenous factors such as age, sex, body composition and genetics as well as underlying pathologies.The levels of the enormous array of unique small-molecule metabolites are usually kept tightly regulated by the activity of a very large array of enzymes and transporters responsible for the production, transformation, degradation, and compartmentalization of these small molecules.The levels of the endogenous small molecules present in the brain are normally tightly regulated.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-F0002R
    NADP (sodium salt) (Standard)
    NADP (sodium salt) (Standard)
  • HY-113365S3
    Cholestenone-d7
    Cholestenone-d7 is deuterium labeled Cholestenone. Cholestenone (4-Cholesten-3-one), the intermediate oxidation product of cholesterol, is metabolized primarily in the liver. Cholestenone is highly mobile in membranes and influences cholesterol flip-flop
    Cholestenone-d<sub>7</sub>
  • HY-N0492AR
    α-Lipoic Acid (sodium) (Standard)
    α-Lipoic Acid (sodium) (Standard)
  • HY-155410
    HPSE1-IN-1
    HPSE1-IN-1 (compound 16) is a selective inhibitor of Heparanase-1 (HPSE1) with moderate inhibitory activity against exo-β-d-glucuronidase (GUSβ) and glucocerebrosidase (GBA).
    HPSE1-IN-1
  • HY-P2976
    Lipoxygenase, general
    Lipoxygenase, general (LOX) is a dioxygenase, is often used in biochemical studies. Lipoxygenase, general catalyzes the formation of corresponding hydroperoxides from polyunsaturated fatty acids such as linoleic acid and arachidonic acid.
    Lipoxygenase, general
  • HY-118041
    PMPMEase-IN-1
    PMPMEase-IN-1 is an allylated methylated protein methylesterase inhibitor with the property of inhibiting PMPMEase activity. PMPMEase-IN-1 may provide a useful strategy for cancer inhibition by enhancing its affinity for polyisoprenyl derivatives. PMPMEase-IN-1 showed the potential to have an effective concentration (EC50) value in causing degeneration of human neuroblastoma SH-SY5Y cells. Specific inhibition of PMPMEase-IN-1 may help regulate the metabolism of polyisoprenyl proteins and thus maintain normal cell survival. Further development and application of PMPMEase-IN-1 may open up new avenues for inhibiting degenerative diseases and cancer.
    PMPMEase-IN-1
  • HY-128749AR
    D-Glucaric acid (tetrahydrate) (Standard)
    D-Glucaric acid (tetrahydrate) (Standard) is the analytical standard of D-Glucaric acid (tetrahydrate). This product is intended for research and analytical applications. D-Glucaric acid tetrahydrate is the end-products of the D-glucuronic acid pathway in mammals. D-Glucaric acid tetrahydrate is also found in fruits and vegetables. D-Glucaric acid tetrahydrate can be used to reduce cholesterol and inhibits tumor development. D-Glucaric acid tetrahydrate also enhances human immunity and reduce cancer risks.
    D-Glucaric acid (tetrahydrate) (Standard)
  • HY-101411R
    4-Acetamidobutanoic acid (Standard)
    Josamycin propionate (Standard) is the analytical standard of Josamycin propionate. This product is intended for research and analytical applications. Josamycin propionate is classified as a macrolide antibiotic.
    4-Acetamidobutanoic acid (Standard)
  • HY-N1459S
    (24Rac)-Campesterol-d7
    Campesterol-d7 ((24R)-5-Ergosten-3β-ol-d7) is the deuterium labeled Campesterol. Campesterol is a plant sterol with cholesterol lowering and anticarcinogenic effects.
    (24Rac)-Campesterol-d7
  • HY-N15208
    (3S,5S)-1-(4-Hydroxy-3-methoxyphenyl)-7-phenyl-3,5-heptanediol
    (3S,5S)-1-(4-Hydroxy-3-methoxyphenyl)-7-phenyl-3,5-heptanediol is a heptane compound that can be isolated from Alpinia oxyphylla.
    (3S,5S)-1-(4-Hydroxy-3-methoxyphenyl)-7-phenyl-3,5-heptanediol
  • HY-N10215
    Canadensolide
    Canadensolide is an antifungal metabolite of Penicillium canadense.
    Canadensolide
  • HY-E70335
    Colipase, Porcine
    Colipase, Porcine is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible.
    Colipase, Porcine
  • HY-125061
    Hydroxythiohomosildenafil
    Hydroxythiohomosildenafil is a Sildenafil (HY-15025) class compound that can be used to study erectile dysfunction.
    Hydroxythiohomosildenafil
  • HY-Y0966S9
    Glycine-15N,d2
    Glycine-15N,d2 is the deuterium and 15N-labeled Glycine. Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors.
    Glycine-<sup>15</sup>N,d<sub>2</sub>
  • HY-10585S4
    Valproic acid-d4-1
    Valproic acid-d4-1 is the deuterium labeled Valproic acid. Valproic acid (VPA; 2-Propylpentanoic Acid) is an HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium salt is used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches[1][2].
    Valproic acid-d<sub>4</sub>-1
  • HY-N7103R
    Ethyl oleate (Standard)
    Ethyl oleate (Standard) is the analytical standard of Ethyl oleate. This product is intended for research and analytical applications. Ethyl oleate is an orally active fatty acid ester formed from the condensation of oleic acid and ethanol. Ethyl oleate is the main fatty acid ethyl ester in the blood after alcohol ingestion. Ethyl oleate has no obvious toxicity to rats and its absorption, distribution and excretionare similar to triacylglycerol. Ethyl oleate can accelerate the drying process of certain foods and can also be used as a liquid lipid component in nanostructured lipid carriers.
    Ethyl oleate (Standard)
  • HY-118824
    Moschamine
    Moschamine acts as an inhibitor of excessive superoxide production in mitochondria.
    Moschamine
  • HY-Y0136R
    3-Indoleacetonitrile (Standard)
    3-Indoleacetonitrile (Standard)
  • HY-P1725
    Leucomyosuppressin
    Leucomyosuppressin, an insect neuropeptide, is an inhibitory myotropic peptide. Leucomyosuppressin inhibits evoked transmitter release at the mealworm neuromuscular junction.
    Leucomyosuppressin
  • HY-N0650S12
    L-Serine-15N,d3
    L-Serine-15N,d3 is the deuterium and 15N labeled L-Serine[1]. L-Serine ((-)-Serine;(S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation[2].
    L-Serine-<sup>15</sup>N,d<sub>3</sub>
Cat. No. Product Name / Synonyms Application Reactivity