2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Endogenous Metabolite

Endogenous Metabolite

Endogenous Metabolite

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Metabolite results when a drug is metabolized into a modified form which continues to produce effects. A metabolome in a given body fluid is influenced by endogenous factors such as age, sex, body composition and genetics as well as underlying pathologies.The levels of the enormous array of unique small-molecule metabolites are usually kept tightly regulated by the activity of a very large array of enzymes and transporters responsible for the production, transformation, degradation, and compartmentalization of these small molecules.The levels of the endogenous small molecules present in the brain are normally tightly regulated.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-113410S
    3-Methylglutaric acid-d4
    3-Methylglutaric acid-d4 is the deuterium labeled 3-Methylglutaric acid[1]. 3-Methylglutaric acid, a leucine metabolite, is a conspicuous C6 dicarboxylic organic acid classically associated with two distinct leucine pathway enzyme deficiencies, 3-hydroxy-3-methylglutaryl CoA lyase (HMGCL) and 3-methylglutaconyl CoA hydratase (AUH)[2][3].
    3-Methylglutaric acid-d<sub>4</sub>
  • HY-P10549
    NGFFFamide
    NGFFFamide is a muscle-active neuropeptide found in sea urchins. NGFFFamide regulates muscle activity by directly interacting with receptor proteins on muscle cells, or indirectly by stimulating nerves or other cell types to release muscle-active factors. NGFFFamide can be used to study muscle contraction and relaxation.
    NGFFFamide
  • HY-130434
    12-SAHSA
    12-SAHSA is a fatty acid ester of hydroxy fatty acids (FAHFAs). 12-SAHSA decreases in the human serum of breast cancer.
    12-SAHSA
  • HY-145473
    1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE
    1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE (15(S)-HETE-SAPE) is a phospholipid containing stearic acid (HY-B2219) at the sn-1 position and 15(S)-HETE (HY-113336) at the sn-2 position. 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE is formed by direct oxidation of 1-stearoyl-2-arachidonoyl-sn-glycero-3-PE (SAPE) by 15-LOX in human peripheral mononuclear cells activated with the calcium ionophore A23187 (HY-N6687).
    1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE
  • HY-W009162S2
    Cytidine 5′-monophosphate-d12 dilithium
    Cytidine 5′-monophosphate-d12 (5'-Cytidylic acid-d12 dilithium; 5'-CMP-d12) dilithium is deuterium labeled Cytidine 5'-monophosphate (HY-W009162). Cytidine 5'-monophosphate (5'-Cytidylic acid) is a nucleotide which is used as a monomer in RNA. Cytidine 5'-monophosphate consists of the nucleobase cytosine, the pentose sugar ribose, and the phosphate group.
    Cytidine 5′-monophosphate-d<sub>12</sub> dilithium
  • HY-136648S3
    2'-Deoxyadenosine-5'-triphosphate-d14 dilithium
    2'-Deoxyadenosine-5'-triphosphate-d14 (dATP-d14) dilithium is deuterium labeled 2'-Deoxyadenosine-5'-triphosphate (HY-136648). 2'-Deoxyadenosine-5'-triphosphate (dATP) is a nucleotide used in cells for DNA synthesis (or replication), as a substrate of DNA polymerase.
    2'-Deoxyadenosine-5'-triphosphate-d<sub>14</sub> dilithium
  • HY-W346639
    4(Z),7(Z),10(Z),13(Z)-Hexadecatetraenoic acid methyl ester
    4(Z),7(Z),10(Z),13(Z)-Hexadecatetraenoic acid methyl ester is a type of polyunsaturated fatty acid ester that can be used in cancer research.
    4(Z),7(Z),10(Z),13(Z)-Hexadecatetraenoic acid methyl ester
  • HY-N3101
    Pedalitin
    Pedalitin is a inhibitor of tyrosinase（IC50=0.28 mM） and α-glucosidase（IC50=0.29 mM）.
    Pedalitin
  • HY-N0379S17
    D-Mannose-d-3
    D-Mannose-d-3 is the deuterium labeled D-Mannose. D-Mannose is a carbohydrate, which plays an important role in human metabolism, especially in the glycosylationof specific prote[1][2].
    D-Mannose-d-3
  • HY-107430R
    Oxythiamine (Standard)
    Oxythiamine (Standard)
  • HY-B1899R
    Taurodeoxycholic acid (Standard)
    Taurodeoxycholic acid (Standard)
  • HY-14595R
    Biochanin A (Standard)
    Biochanin A (Standard) is the analytical standard of Biochanin A. This product is intended for research and analytical applications. Biochanin A is a naturally occurring fatty acid amide hydrolase (FAAH) inhibitor, which inhibits FAAH with IC50s of 1.8, 1.4 and 2.4 μM for mouse, rat, and human FAAH, respectively.
    Biochanin A (Standard)
  • HY-112102R
    (22S,23S)-Homobrassinolide (Standard)
    (22S,23S)-Homobrassinolide (Standard)
  • HY-113313S2
    Aldosterone-d4
    		99.30%
    Aldosterone-d4 is the deuterium labeled Aldosterone. Aldosterone is the primary mineralocorticoid. Aldosterone is a steroid hormone, and it is synthesized and secreted in response to renin-angiotensin system activation (RAS) or high dietary potassium by t
    Aldosterone-d<sub>4</sub>
  • HY-111321
    Fuscin
    Fuscin, a fungal metabolite, CCR5 receptor antagonist with anti-HIV effects. Fuscin is a respiration and oxidative phosphorylation inhibitor, and also a mitochondrial SH-dependent transport-linked functions inhibitor.
    Fuscin
  • HY-N0643R
    Carnosol (Standard)
    Carnosol (Standard) is the analytical standard of Carnosol. This product is intended for research and analytical applications. Carnosol is a potent Ribosomal S6 Kinase (RSK2) inhibitor that could be useful for treating gastric cancer, with an IC50 of ~5.5 μM. Carnosol, a Nrf2 activator, increases the nuclear levels of Nrf2 and can promote the expression of heme oxygenase 1 (HMOX1).
    Carnosol (Standard)
  • HY-128421R
    Tridecanedioic acid (Standard)
    Tridecanedioic acid (Standard)
  • HY-W017443S3
    L-Asparagine-15N2,d3 monohydrate
    L-Asparagine-15N2,d3 (monohydrate) is the deuterium and 15N-labeled L-Asparagine monohydrate. L-Asparagine monohydrate ((-)-Asparagine monohydrate) is a non-essential amino acid that is involved in the metabolic control of cell functions in nerve and brain tissue.
    L-Asparagine-<sup>15</sup>N<sub>2</sub>,d<sub>3</sub> monohydrate
  • HY-113658
    ts-SA
    ts-SA is a carbonic anhydrase (CA) inhibitor with activity against seven human CA homologues. ts-SA can bind to the Zn(II) ion in the enzyme active site in a deprotonated form. The organic skeleton of ts-SA extends in the enzyme cavity and participates in multiple interactions with amino acid residues and water molecules. Due to its structural differences, the inhibitory performance of ts-SA is significantly better than that of another pyridine derivative. ts-SA exhibits low nanomolar inhibitory activity and is a multi-target CA inhibitor.
    ts-SA
  • HY-P4523
    FA-Ala-Arg
    FA-Ala-Arg is a dipeptide with furylacryloyl group. FA-Ala-Arg breaks down to produce arginine. While cell-surface Carboxypeptidase-D (CPD) also increases intracellular Arg, which is converted to nitric oxide (NO). FA-Ala-Arg enhances NO production in MCF-7 cells. FA-Ala-Arg also increases the cell survival of prolactin (PRL)-treated cells, PRL regulates CPD mRNA levels in cells.
    FA-Ala-Arg
Cat. No. Product Name / Synonyms Application Reactivity