2. Signaling Pathways
  3. Anti-infection
  4. Beta-lactamase

Beta-lactamase

β-lactamase

Beta-lactamase (β-lactamase) is associated with multiple drug resistance in bacteria. It is able to hydrolyze or degrade the β-lactam ring, which is the core structure and active region of many antibiotic molecules such as penicillin, cephalosporins and kanamycin. Bacteria produce Lactamase in response to beta-lactam antibiotics. Using Lactamase inhibitors inhibits the activity of Lactamase so that it cannot destroy the beta-lactam ring of the antibiotic. Lactamase inhibitors are often used with beta-lactam antibiotics to enhance their effectiveness.

Beta-lactamase Isoform Specific Products:

Beta-lactamase Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-108288R
    Sulbactam pivoxil (Standard)
    		Inhibitor
    Sulbactam pivoxil (Standard)
  • HY-B0466BR
    Cloxacillin (sodium) (Standard)
    		Inhibitor
    Cloxacillin (sodium) (Standard) is the analytical standard of Cloxacillin (sodium). This product is intended for research and analytical applications. Cloxacillin sodium is an orally active antibacterial agent and β-lactamase inhibitor with an IC50 of 0.04 μM. Cloxacillin sodium can suppress the S. aureus-induced inflammatory response by inhibiting the activation of MAPKs, NF-кB and NLRP3-related proteins.
    Cloxacillin (sodium) (Standard)
  • HY-119945
    Brobactam
    		Inhibitor
    Brobactam is a potent synthetic wide spectrum β-lactamase inhibitor. Brobactam has antibacterial activity.
    Brobactam
  • HY-138247
    β-Lactamase-IN-2
    		Inhibitor 98.59%
    β-Lactamase-IN-2 is a beta-lactamase inhibitor, extracted from patent WO 2019075084 A1, compound 1. β-Lactamase-IN-2 has anti-microbial and anti-bacterial effects.
    β-Lactamase-IN-2
  • HY-B0466R
    Cloxacillin (sodium monohydrate) (Standard)
    		Inhibitor
    Cloxacillin (sodium monohydrate) (Standard) is the analytical standard of Cloxacillin (sodium monohydrate). This product is intended for research and analytical applications. Cloxacillin sodium monohydrate is an orally active antibacterial agent and β-lactamase inhibitor with an IC50 of 0.04 μM. Cloxacillin sodium monohydrate can suppress the S. aureus-induced inflammatory response by inhibiting the activation of MAPKs, NF-кB and NLRP3-related proteins.
    Cloxacillin (sodium monohydrate) (Standard)
  • HY-139699
    GT-055
    		Inhibitor
    GT-055 (LCB18-055) is a novel broad-spectrum β-lactamase inhibitor.
    GT-055
  • HY-144229
    trans-Cephalosporin
    		Inhibitor
    Trans substituted cephalosporin is an effective NDM-1 inhibitor，with an IC50 value of 0.13 μM.
    trans-Cephalosporin
  • HY-132824
    Ledaborbactam etzadroxil
    		Inhibitor
    Ledaborbactam etzadroxil (VNRX-7145) is an orally active Ambler class A, C, and D β-lactamase enzymes inhibitor.
    Ledaborbactam etzadroxil
  • HY-105284R
    Sulopenem (Standard)
    		Inhibitor
    N-Acetylneuraminic acid (Standard) is the analytical standard of N-Acetylneuraminic acid. This product is intended for research and analytical applications. N-Acetylneuraminic acid (NANA; Lactaminic acid), a nonphenolic structure, is the predominant form of sialic from Collocalia esculenta. N-Acetylneuraminic acid plays a biological role in myocardial injury, melanoma and viral or bacterial infection. N-Acetylneuraminic acid inhibits melanogenesis by reducing tyrosinase activity and triggers myocardial injury in vitro and in vivo by activation of the Rho/Rho-associated signaling pathway through binding to RhoA and Cdc42. N-Acetylneuraminic acid may prevent high fat diet (HFD)-induced inflammation and oxidative stress, thereby prevents hyperlipidemia-associated inflammation and oxidative stress. N-Acetylneuraminic acid is promising for research in the field of melanoma, coronary artery, obesity-related diseases and hyperlipidemia.
    Sulopenem (Standard)
  • HY-B0555BS
    Nafcillin-d5 sodium
    		Inhibitor
    Nafcillin-d5 (sodium) is the deuterium labeled Nafcillin sodium. Nafcillin sodium, an antibiotic, is a reversible inhibitor of β-lactamase. Nafcillin sodium can be used for the research of staphylococcal infections[1][2].
    Nafcillin-d<sub>5</sub> sodium
  • HY-P2998
    β-Lactamase
    β-Lactamase is the enzyme produced by bacteria. β-Lactamase mediates β-lactam resistance.
    β-Lactamase
  • HY-146075
    β-Lactamase-IN-8
    		Inhibitor
    β-Lactamase-IN-8 (compound 20) is a potent and oral bioavailable broad-spectrum cyclic boronate β-lactamase inhibitor. β-Lactamase-IN-8 can be used for researching antibacteria.
    β-Lactamase-IN-8
  • HY-144100
    β-Lactamase-IN-7
    		Inhibitor
    β-Lactamase-IN-7 (compound 14) is a potent VIM-Type metallo-β-lactamase inhibitor, with Kis of 1.26 μM and 0.54 μM for VIM-1 and VIM-4, respectively. β-Lactamase-IN-7 can effectively inhibit Klebsiella pneumoniae.
    β-Lactamase-IN-7
  • HY-163382
    Cbz-Gly-Pro-Ala-O-cinnamyl
    		Inhibitor
    Cbz-Gly-Pro-Ala-O-cinnamyl (compound 25) is a small peptide targeting BACE-1 and AChE with the IC50 values of 0.02 μM and 1 μM, respectively. Cbz-Gly-Pro-Ala-O-cinnamyl shows neuroprotective effect and can be used for study of Alzheimer’s disease.
    Cbz-Gly-Pro-Ala-O-cinnamyl
  • HY-155504
    Metallo-β-lactamase-IN-11
    		Inhibitor
    Metallo-β-lactamase-IN-11 (compound 5f) is a Metallo-β-lactamases (MBLs) inhibitor, potent against bacterial metallophyllactamase CphA (IC50=45 µM). Metallo-β-lactamase-IN-11 (10 µM) inhibits NDM-1 by 49% and AIM-1 by 61%. Metallo-β-lactamase-IN-11 can be used in the research of inhibiting antibiotic resistance.
    Metallo-β-lactamase-IN-11
  • HY-139779
    β-Lactamase-IN-5
    		Inhibitor
    β-Lactamase-IN-5 is a β-lactamase inhibitor extracted from patent WO2013149121A1, compound 720. β-Lactamase-IN-5 can be used for the research of bacterial infections.
    β-Lactamase-IN-5
  • HY-115872
    β-Lactamase-IN-6
    		Inhibitor
    β-Lactamase-IN-6 is a β-Lactamase inhibitor that shows high antibacetrial activity.
    β-Lactamase-IN-6
  • HY-19647
    Ritipenem acoxil
    		Inhibitor
    Ritipenem acoxil (FCE 22891; RIPM-AC) is an oral active beta-lactamase antibiotic and can be used for study of bacterial pneumonia.
    Ritipenem acoxil
  • HY-B1484R
    Moxalactam (sodium salt) (Standard)
    		Inhibitor
    Moxalactam (sodium salt) (Standard) is the analytical standard of Moxalactam (sodium salt). This product is intended for research and analytical applications. Moxalactam (Latamoxef) sodium salt is a synthetic oxa-β-lactam antibiotic. Moxalactam sodium salt has a broad spectrum of activity against Gram-positive and Gram-negative aerobic and anaerobic bacteria. Moxalactam sodium salt inhibits production of β-lactamases.
    Moxalactam (sodium salt) (Standard)
  • HY-152105
    Metallo-β-lactamase-IN-9
    		Inhibitor
    Metallo-β-lactamase-IN-9 (Compound 23) is a pan metallo-beta-lactamase (MBL) inhibitor with IC50s of 35, 269 and 369 nM against NDM-1, VIM-1 and IMP-1, respectively.
    Metallo-β-lactamase-IN-9
Beta-lactamase Isoform Comparison

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