2. Signaling Pathways
  3. Anti-infection
  4. Beta-lactamase

Beta-lactamase

β-lactamase

Beta-lactamase (β-lactamase) is associated with multiple drug resistance in bacteria. It is able to hydrolyze or degrade the β-lactam ring, which is the core structure and active region of many antibiotic molecules such as penicillin, cephalosporins and kanamycin. Bacteria produce Lactamase in response to beta-lactam antibiotics. Using Lactamase inhibitors inhibits the activity of Lactamase so that it cannot destroy the beta-lactam ring of the antibiotic. Lactamase inhibitors are often used with beta-lactam antibiotics to enhance their effectiveness.

Beta-lactamase Isoform Specific Products:

Beta-lactamase Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-169973
    PhoPS
    		Inhibitor
    PhoPS is the photocaged inhibitor for β-lactamase. PhoPS is activated upon light irradiation, and active β-lactamase inhibitor Sulbactam (HY-B0334) is released. PhoPS inhibits the synthesis of bacterial cell wall and the formation of E. coli biofilm, exhibits antimicrobial activity.
    PhoPS
  • HY-B1418R
    Tazobactam (Standard)
    		Inhibitor
    Tazobactam (Standard) is the analytical standard of Tazobactam. This product is intended for research and analytical applications. Tazobactam (CL-298741) is a potent β-lactamases inhibitor and penicillin antibiotic. Tazobactam has antibacterial activity. Tazobactam can be used for pneumonia research.
    Tazobactam (Standard)
  • HY-B1459AR
    Dicloxacillin (Standard)
    		Inhibitor
    Dicloxacillin (Standard) is the analytical standard of Dicloxacillin. This product is intended for research and analytical applications. Dicloxacillin is a β-lactam antibiotic of the penicillin family. Dicloxacillin against Gram-positive bacteria. Dicloxacillin is active against β-lactamase-producing organisms such as Staphylococcus aureus.
    Dicloxacillin (Standard)
  • HY-A0088R
    Cefotaxime (sodium) (Standard)
    		Inhibitor
    Cefotaxime (sodium) (Standard) is the analytical standard of Cefotaxime (sodium). This product is intended for research and analytical applications. Cefotaxime (Cefotaxim) sodium, a β-lactamase stable cephalosporin and a third-generation cephalosporin antibiotic, possesses broad-spectrum antibiotic activity against numerous Gram-positive and Gram-negative bacteria.
    Cefotaxime (sodium) (Standard)
  • HY-16752R
    Relebactam (Standard)
    		Inhibitor
    Relebactam (Standard) is the analytical standard of Relebactam. This product is intended for research and analytical applications. Relebactam is a diazabicyclooctane inhibitor with activity against a wide spectrum of β-lactamases, including class A (extended-spectrum β-lactamases and KPC) and class C (AmpC) enzymes. Relebactam shows antibacterial activity.
    Relebactam (Standard)
  • HY-14879S2
    Avibactam sodium salt-13C5
    		Inhibitor
    Avibactam sodium salt-13C5 (NXL-104-13C5) is 13C labeled Avibactam (sodium). Avibactam sodium (NXL-104) is a covalent and reversible non-β-lactam β-lactamase inhibitor which inhibits β-lactamase TEM-1 and CTX-M-15 with IC50s of 8 nM and 5 nM, respectively.
    Avibactam sodium salt-<sup>13</sup>C<sub>5</sub>
  • HY-B1275AR
    Cephalothin (Standard)
    		Inhibitor
    Cephalothin (Standard) is the analytical standard of Cephalothin. This product is intended for research and analytical applications. Cephalotin (Cephalotin) is a beta-lactam antibiotic, inhibits class C β-lactamase AmpC, with an Ki of 0.32 µM.
    Cephalothin (Standard)
  • HY-113557
    DNAC-1
    		Activator
    DNAC-1 is a potent antibacterial agent. DNAC-1 enhances β-lactam activity against Gram positive and Gram negative pathogens.
    DNAC-1
  • HY-A0256BR
    Clavulanate (lithium) (Standard)
    		Inhibitor
    Clavulanate (lithium) (Standard) is the analytical standard of Clavulanate (lithium). This product is intended for research and analytical applications. Clavulanate lithium is a potent β-lactamase inhibitor and acts as an antibiotic.
    Clavulanate (lithium) (Standard)
  • HY-105751
    Kalafungin
    		Inhibitor
    Kalafungin is an antibiotic, antimicrobial agent and a β-lactamase inhibitor from marine Streptomyces, with IC50 of 225.37 μM. Kalafungin destroys cell membranes. Kalafungin shows inhibitory activities against a variety of pathogenic fungi, yeasts, protozoa, gram-positive bacteria (such as S. aureus ATCC 33591 and S. aureus ATCC 23591), and, to a lesser extent, gram-negative bacteria.
    Kalafungin
  • HY-117951
    ANT431
    		Inhibitor
    ANT431 is a metallo-β-lactamase inhibitor that also restores the effectiveness of Meropenem (HY-13678) in a mouse thigh Escherichia coli infection model.
    ANT431
  • HY-163191
    NDM-1 inhibitor-5
    		Inhibitor
    NDM-1 inhibitor-5 (compound 57) is a potent NDM-1 inhibitor, with a Ki of 2.5 μM. NDM-1 inhibitor-5 also shows antibacterial synergistic activity with meropenem (HY-13678).
    NDM-1 inhibitor-5
  • HY-B0593R
    Ceftazidime (Standard)
    		Inhibitor
    Ceftazidime (Standard) is the analytical standard of Ceftazidime. This product is intended for research and analytical applications. Ceftazidime (GR20263), an antibiotic, has a broad spectrum activity against Gram-positive and Gram-negative aerobic bacteria. Ceftazidime is also active against Enterobacteriaceae (including β-lactamase-positive strains) and is resistant to hydrolysis by most β-lactamases.
    Ceftazidime (Standard)
  • HY-14879R
    Avibactam (free acid) (Standard)
    		Inhibitor
    Avibactam (free acid) (Standard)
  • HY-168861
    NDM-1 inhibitor-8
    		Inhibitor
    NDM-1 inhibitor-8 (Compound 18b) is the covalent inhibitor for new delhi metallo-β-lactamase-1 (NDM-1) with an IC50 of 7.03 μM. NDM-1 inhibitor-8 inhibits the drug resistant strains, exhibits synergistic antibacterial effect with the use of Meropenem (HY-13678). NDM-1 inhibitor-8 exhibits anti-infectious activity in mouse models.
    NDM-1 inhibitor-8
  • HY-17452AR
    Cefditoren Pivoxil (Standard)
    		Inhibitor
    Cefditoren Pivoxil (Standard) is the analytical standard of Cefditoren Pivoxil. This product is intended for research and analytical applications. Cefditoren Pivoxil (ME 1207) is a broad-spectrum, third-generation, oral cephalosporin antibacterial with enhanced stability against many common β lactamases. Cefditoren Pivoxil has activity against Gram-negative organisms and Gram-positive organisms. Cefditoren Pivoxil can be used in the research of infection diseases such as acute exacerbations of chronic bronchitis, community-acquired pneumonia (CAP), streptococcal pharyngitis/tonsillitis, or uncomplicated skin and skin structure infections.
    Cefditoren Pivoxil (Standard)
  • HY-120366
    WCK-5153
    WCK-5153 is a Penicillin-Binding Protein 2 (PBP2) inhibitor with an IC50 of 0.14 μg/ml (for P. aeruginosa PBP2) and acts as a β-lactam enhancer against Pseudomonas aeruginosa. WCK-5153 can be used in studies of multidrug-resistant (MDR) pathogens.
    WCK-5153
  • HY-A0088S
    Cefotaxime-d3 sodium
    		Inhibitor
    Cefotaxime-d3 (sodium) is the deuterium labeled Cefotaxime (sodium salt). Cefotaxime sodium salt, a β-lactamase stable cephalosporin and a third-generation cephalosporin antibiotic, possesses broad-spectrum antibiotic activity against numerous Gram-positive and Gram-negative bacteria[1][2][3][4][5].
    Cefotaxime-d<sub>3</sub> sodium
  • HY-B0555BR
    Nafcillin (sodium) (Standard)
    		Inhibitor
    Nafcillin (sodium) (Standard) is the analytical standard of Nafcillin (sodium). This product is intended for research and analytical applications. Nafcillin sodium, an antibiotic, is a reversible inhibitor of β-lactamase. Nafcillin sodium can be used for the research of staphylococcal infections.
    Nafcillin (sodium) (Standard)
  • HY-16752A
    Relebactam sodium
    		Inhibitor
    Relebactam sodium (MK-7655 sodium) is a potent and selective β-lactamase inhibitor with the activity of delaying the development of bacterial resistance to antibiotics. Relebactam sodium can bind to a variety of β-lactamases, thereby improving the efficacy of β-lactam antibiotics. Relebactam sodium shows good application potential in inhibiting complicated bacterial infections.
    Relebactam sodium
Beta-lactamase Isoform Comparison

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.