A3AR antagonist 2

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A3AR antagonist 2 (compound 18) is a potent Human A3 adenosine receptor antagonist with an K_i value of 4.54 nM.

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A3AR antagonist 2 Chemical Structure

CAS No. : 1144161-05-6

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View All Isoforms

Adenosine A₁ receptor (A₁R) Adenosine A_2A receptor (A_2AR) Adenosine A_2B receptor (A_2BR) Adenosine A₃ receptor (A₃R)

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Purity & Documentation
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Description

A3AR antagonist 2 (compound 18) is a potent Human A3 adenosine receptor antagonist with an K_i value of 4.54 nM^[1].

IC₅₀ & Target^[1]

hA₃

4.54 nM (Ki)

Molecular Weight

412.40

Formula

C₂₂H₁₆N₆O₃

CAS No.

1144161-05-6

SMILES

O=C(NC1=NC2=NC=CC=C2N3C1=NN(C4=CC=C(OC)C=C4)C3=O)C5=CC=CC=C5

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Pyrido[2,3-e]-1,2,4-triazolo[4,3-a]pyrazin-1-one as a New Scaffold To Develop Potent and Selective Human A3 Adenosine Receptor Antagonists. Synthesis, Pharmacological Evaluation, and Ligand?Receptor Modeling Studies J. Med. Chem., 2009, 52 (8), pp 2407-2419

[2]. Vittoria Colotta, et al. Pyrido[2,3-e]-1,2,4-triazolo[4,3-a]pyrazin-1-one as a New Scaffold To Develop Potent and Selective Human A3 Adenosine Receptor Antagonists. Synthesis, Pharmacological Evaluation, and Ligand−Receptor Modeling Studies. J. Med. Chem. 2009, 52, 8, 2407-2419.