2. PROTAC Others
  3. PROTACs Others
  4. ACBI3

ACBI3 (compound 7) is a PROTAC targeting KRAS. ACBI3 is composed of PROTAC target protein ligand pan-KRAS degrader 1 (HY-162960) (red part), E3 ligase ligand E3 ligase Ligand 43 (HY-401613) (blue part) and PROTAC Linker 1-Bromo-4-(ethynyloxy)butane (HY-169992) (black part), among which the conjugate of E3 ubiquitin ligase ligand + Linker is E3 Ligase Ligand-linker Conjugate 143 (HY-169995).

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ACBI3 Chemical Structure

ACBI3 Chemical Structure

CAS No. : 2938169-76-5

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10 mg USD 1200 Ask For Quote & Lead Time
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50 mg USD 2857 Ask For Quote & Lead Time

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ACBI3 Related Antibodies

Top Publications Citing Use of Products

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

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Description

ACBI3 (compound 7) is a PROTAC targeting KRAS. ACBI3 is composed of PROTAC target protein ligand pan-KRAS degrader 1 (HY-162960) (red part), E3 ligase ligand E3 ligase Ligand 43 (HY-401613) (blue part) and PROTAC Linker 1-Bromo-4-(ethynyloxy)butane (HY-169992) (black part), among which the conjugate of E3 ubiquitin ligase ligand + Linker is E3 Ligase Ligand-linker Conjugate 143 (HY-169995)[1].

Molecular Weight

1019.25

Formula

C50H62N14O6S2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

NC(SC1=C2[C@](C3=NC(C4=NC(N5CCCN(CCCCOC(N=N6)=CN6[C@@H](C(C)C)C(N7[C@H](C(N[C@@H](CO)C8=CC=C(C=C8)C9=C(N=CS9)C)=O)C[C@@H](O)C7)=O)C[C@@H]5C)=NC=C4)=NO3)(C)CCC1)=C2C#N
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Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (245.28 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9811 mL 4.9056 mL 9.8111 mL
5 mM 0.1962 mL 0.9811 mL 1.9622 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.9811 mL 4.9056 mL 9.8111 mL 24.5278 mL
5 mM 0.1962 mL 0.9811 mL 1.9622 mL 4.9056 mL
10 mM 0.0981 mL 0.4906 mL 0.9811 mL 2.4528 mL
15 mM 0.0654 mL 0.3270 mL 0.6541 mL 1.6352 mL
20 mM 0.0491 mL 0.2453 mL 0.4906 mL 1.2264 mL
25 mM 0.0392 mL 0.1962 mL 0.3924 mL 0.9811 mL
30 mM 0.0327 mL 0.1635 mL 0.3270 mL 0.8176 mL
40 mM 0.0245 mL 0.1226 mL 0.2453 mL 0.6132 mL
50 mM 0.0196 mL 0.0981 mL 0.1962 mL 0.4906 mL
60 mM 0.0164 mL 0.0818 mL 0.1635 mL 0.4088 mL
80 mM 0.0123 mL 0.0613 mL 0.1226 mL 0.3066 mL
100 mM 0.0098 mL 0.0491 mL 0.0981 mL 0.2453 mL
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ACBI3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ACBI32938169-76-5ACBI 3ACBI-3PROTACsOthersKRAS degraderInhibitorinhibitorinhibit

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