Angiotensinogen (1-14), human TFA 

Angiotensinogen (1-14), human TFA is a fragment of the renin substrate angiotensinogen. Angiotensinogen is naturally occurring substrate for renin and a precursor for all angiotensin peptides^[1][2].

Angiotensinogen (AGT) is the only precursor of all angiotensin peptides. Human AGT has 485 amino acids, including a 33 amino-acid signal peptide. The 10 N-terminal amino acids are cleaved by renin to provide angiotensin I (AngI), which is the source for an array of active angiotensin peptides^[1].
Angiotensinogen isolated from most species is cleaved by human renin. Synthetic peptides containing the N-terminal amino-acid sequence of angiotensinogen were renin substrates^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1760.01 (free acid)

C₈₃H₁₂₂N₂₄O₁₉.xC₂HF₃O₂

DRVYIHPFHLVIHN

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Lu H, et al. Structure and functions of angiotensinogen. Hypertens Res. 2016 Jul;39(7):492-500.  [Content Brief]

  [2]. Burton J, et al. The amino-acid residues on the C-terminal side of the cleavage site of angiotensinogeninfluence the species specificity of reaction with renin. iochim Biophys Acta. 1988 Jan 4;952(1):8-12.  [Content Brief]