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Carnostatine hydrochloride  (Synonyms: SAN9812 hydrochloride)

Cat. No.: HY-112431A Purity: 99.90%
COA Handling Instructions

Molarity Calculator

Carnostatine hydrochloride (SAN9812 hydrochloride) is a potent and selective carnosinase 1 (CN1) inhibitor with a Ki of 11 nM for human recombinant CN1. Carnostatine hydrochloride can be used for the treatment of diabetic nephropathy (DN).

For research use only. We do not sell to patients.

Carnostatine hydrochloride Chemical Structure

Carnostatine hydrochloride Chemical Structure

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Based on 1 publication(s) in Google Scholar

Other Forms of Carnostatine hydrochloride:

Carnostatine hydrochloride Related Antibodies

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Description

Carnostatine hydrochloride (SAN9812 hydrochloride) is a potent and selective carnosinase 1 (CN1) inhibitor with a Ki of 11 nM for human recombinant CN1. Carnostatine hydrochloride can be used for the treatment of diabetic nephropathy (DN)[1].

IC50 & Target

Ki: 11 nM (human CN1)[1]
In Vitro

Carnostatine (SAN9812) also inhibits CN1 activity in human serum and serum of transgenic mice-overexpressing human CN1. Carnostatine, with an IC50 value of 18 nM on human recombinant CN1 at a carnosine concentration of 200 µM, i.e., close to the Km of 190 µM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Carnostatine hydrochloride Related Antibodies
In Vivo

Subcutaneous administration of 30 mg/kg Carnostatine (SAN9812) leads to a sustained reduction in circulating CN1 activity in human CN1 transgenic (TG) mice. Simultaneous administration of Carnosine and Carnostatine increases carnosine levels in plasma and kidney by up to 100-fold compared to treatment-naïve CN1-overexpressing mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Human carnosinase (CNDP1) transgenic mice on a BTBR wt/ob background[1]
Dosage: 3 mg/kg i.v. or 30 mg/kg s.c. (Pharmacokinetic Analysis)
Administration: Single bolus administration
Result: Subcutaneous administration of 30 mg/kg led to a sustained reduction in circulating CN1 activity.
Molecular Weight

292.72

Formula

C10H17ClN4O4
Appearance

Solid

Color

White to off-white

SMILES

OC([C@@H](NC([C@@H](O)CCN)=O)CC1=CNC=N1)=O.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (854.06 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : ≥ 200 mg/mL (683.25 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4162 mL 17.0812 mL 34.1623 mL
5 mM 0.6832 mL 3.4162 mL 6.8325 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (341.62 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.90%

COA (250 KB) HNMR (274 KB) LCMS (254 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 3.4162 mL 17.0812 mL 34.1623 mL 85.4058 mL
5 mM 0.6832 mL 3.4162 mL 6.8325 mL 17.0812 mL
10 mM 0.3416 mL 1.7081 mL 3.4162 mL 8.5406 mL
15 mM 0.2277 mL 1.1387 mL 2.2775 mL 5.6937 mL
20 mM 0.1708 mL 0.8541 mL 1.7081 mL 4.2703 mL
25 mM 0.1366 mL 0.6832 mL 1.3665 mL 3.4162 mL
30 mM 0.1139 mL 0.5694 mL 1.1387 mL 2.8469 mL
40 mM 0.0854 mL 0.4270 mL 0.8541 mL 2.1351 mL
50 mM 0.0683 mL 0.3416 mL 0.6832 mL 1.7081 mL
60 mM 0.0569 mL 0.2847 mL 0.5694 mL 1.4234 mL
80 mM 0.0427 mL 0.2135 mL 0.4270 mL 1.0676 mL
100 mM 0.0342 mL 0.1708 mL 0.3416 mL 0.8541 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Carnostatine hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CarnostatineSAN9812SAN 9812SAN-9812OthersCarnosinaseCN1Diabeticnephropathiesdiabetes ,T2DrenaldiseaseESRDInhibitorinhibitorinhibit

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