Cdc7-IN-21

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Cdc7-IN-21 (compound 10c) is a potent and selective Cdc7 inhibitor with an IC₅₀ of 0.07 nM. Cdc7-IN-21 can be used to study cancer.

For research use only. We do not sell to patients.

Cdc7-IN-21 Chemical Structure

CAS No. : 1330781-04-8

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Cdc7-IN-21 (compound 10c) is a potent and selective Cdc7 inhibitor with an IC₅₀ of 0.07 nM. Cdc7-IN-21 can be used to study cancer^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
COLO 205	EC₅₀	1100 nM Compound: 10c	Cytotoxicity against human COLO205 cells after 3 days by CellTiter-Glo luminescent cell viability assay Cytotoxicity against human COLO205 cells after 3 days by CellTiter-Glo luminescent cell viability assay	[PMID: 28533114]
COLO 205	EC₅₀	1100 nM Compound: Cpd I	Antiproliferative activity against human COLO205 cells assessed as reduction in cell growth after 3 days by CellTiter-Glo luminescence assay Antiproliferative activity against human COLO205 cells assessed as reduction in cell growth after 3 days by CellTiter-Glo luminescence assay	[PMID: 31895562]
HeLa	IC₅₀	250 nM Compound: Cpd I	Inhibition of CDC7 in human HeLa cells assessed as inhibition of MCM2 phosphorylation at Ser40 residue in human HeLa cells after 7 hrs by Western blot analysis Inhibition of CDC7 in human HeLa cells assessed as inhibition of MCM2 phosphorylation at Ser40 residue in human HeLa cells after 7 hrs by Western blot analysis	[PMID: 31895562]
HeLa	IC₅₀	250 nM Compound: 10c	Inhibition of Cdc7 in human HeLa cells assessed as reduction in MCM2 phosphorylation at ser40 residues after 7 hrs by Western blot analysis Inhibition of Cdc7 in human HeLa cells assessed as reduction in MCM2 phosphorylation at ser40 residues after 7 hrs by Western blot analysis	[PMID: 28533114]

Molecular Weight

315.39

Formula

C₁₅H₁₇N₅OS

CAS No.

1330781-04-8

SMILES

O=C1N=C(CN2CCCC2)NC3=C1SC(C4=CNN=C4C)=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Kurasawa O, et al. 2-Aminomethylthieno [3, 2-d] pyrimidin-4 (3H)-ones bearing 3-methylpyrazole hinge binding moiety: Highly potent, selective, and time-dependent inhibitors of Cdc7 kinase[J]. Bioorganic & Medicinal Chemistry, 2017, 25(14): 3658-3670.

Cdc7-IN-21 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cdc7-IN-211330781-04-8CDKCyclin dependent kinaseserinethreonineInhibitorinhibitorinhibit

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