CDK14

CDK14, also named PFTAIREI, is a CDC2-associated serine/threonine protein kinase and can act as an essential regulator of CCNs and cell cycle development. Interestingly, CDK14 can regulate cell cycle progression and cell proliferation by interacting with CCNY that is the regulatory submit of CDK14 and promotes Wnt signaling by mediating cell cycle-dependent low-density-lipoprotein receptor-related protein 6 (LRP6) phosphorylation which is a key regulatory nexus in Wnt/β-catenin pathway.

CDK14 Inhibitors (4)

CDK14 Related Products (4):

By Type:	Pan (4)

Cat. No.	Product Name	Effect	Purity

HY-127104

FMF-04-159-2	Inhibitor	99.48%
FMF-04-159-2 is a covalent CDK14 inhibitor. FMF-04-159-2 inhibits CDK14 and CDK2 with IC₅₀s of 39.6 nM and 256 nM in NanoBRET assay, respectively.

HY-X0150

JSH-150	Inhibitor	98.36%
JSH-150 is a highly selective and potent CDK9 inhibitor with an IC₅₀ of 1 nM.

HY-X0009A

JSH-009 dimaleate	Inhibitor
JSH-009 dimaleate (Compound 1) is a potent and highly selective CDK9 inhibitor with an IC₅₀ of 0.928 nM. JSH-009 can effectively inhibit the growth of subcutaneous tumor (cute myelogenous leukemia MV4-11) mice.

HY-160213

JA397	Inhibitor
JA397 is a potent and selective inhibitor for the TAIRE family with cellular activity ranging from IC₅₀ values of 21 nM to 307 nM.

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