2. Epigenetics Apoptosis
  3. DNA Methyltransferase Apoptosis
  4. DNMT1-IN-5

DNMT1-IN-5 (Compound 55) is the inhibitor for DNMT that inhibits DNMT1 and DNMT3A with IC50 of 2.42 μM and 14.4 μM. DNMT1-IN-5 exhibits antiproliferative activity in a variety of cancer cell lines (IC50s for TMD-8, DOHH2, MOLM-13, THP-1, RPIM-8226 and HCT116 are 0.19-2.37 μM), arrests the cell cycle at G2/M phase, and induces apoptosis in TMD-8 and DOHH2 cells. DNMT1-IN-5 exhibits antitumor efficacy in TMD-8 xenograft mouse models.

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DNMT1-IN-5 Chemical Structure

DNMT1-IN-5 Chemical Structure

CAS No. : 2982511-19-1

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DNMT1-IN-5 Related Antibodies

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Description

DNMT1-IN-5 (Compound 55) is the inhibitor for DNMT that inhibits DNMT1 and DNMT3A with IC50 of 2.42 μM and 14.4 μM. DNMT1-IN-5 exhibits antiproliferative activity in a variety of cancer cell lines (IC50s for TMD-8, DOHH2, MOLM-13, THP-1, RPIM-8226 and HCT116 are 0.19-2.37 μM), arrests the cell cycle at G2/M phase, and induces apoptosis in TMD-8 and DOHH2 cells. DNMT1-IN-5 exhibits antitumor efficacy in TMD-8 xenograft mouse models[1].

IC50 & Target

DNMT1

2.42 μM (IC50)

DNMT3A

14.4 μM (IC50)

Molecular Weight

437.56

Formula

C24H32FN7
CAS No.
SMILES

CN1CCC(NC2=C3C(N(C=C3)CCCN4CCCC4)=NC(C5=CC=NC(F)=C5)=N2)CC1
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Purity & Documentation
References
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DNMT1-IN-5 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DNMT1-IN-52982511-19-1DNA MethyltransferaseApoptosisDNMTsDNA MTasesMOLM-13THP-1RPIM-8226HCT116TMD-8DOHH2Balb/C mouseInhibitorinhibitorinhibit

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