2. GPCR/G Protein
  3. G Protein-coupled Receptor Kinase (GRK)
  4. DS-1558

DS-1558 is an orally active small molecule G protein-coupled receptor 40 agonist. DS-1558 not only increases the glucose-stimulated insulin secretion by glucagon like peptide-1 (GLP-1) but also potentiated the maximum insulinogenic effects of GLP-1 after an intravenous glucose injection in normal Sprague Dawley rats. DS-1558 is promising for research of type 2 diabetes.

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DS-1558 Chemical Structure

DS-1558 Chemical Structure

CAS No. : 1202575-67-4

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DS-1558 Related Antibodies

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Description

DS-1558 is an orally active small molecule G protein-coupled receptor 40 agonist. DS-1558 not only increases the glucose-stimulated insulin secretion by glucagon like peptide-1 (GLP-1) but also potentiated the maximum insulinogenic effects of GLP-1 after an intravenous glucose injection in normal Sprague Dawley rats. DS-1558 is promising for research of type 2 diabetes[1].

Molecular Weight

394.38

Formula

C21H21F3O4
CAS No.
SMILES

FC(F)(C1=C2C([C@@H](CC2)OC3=CC=C(C=C3)[C@@H](OCC)CC(O)=O)=CC=C1)F
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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DS-1558 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DS-15581202575-67-4DS1558DS 1558G Protein-coupled Receptor Kinase (GRK)orally activeG protein-coupled receptor 40insulin secretionGLP-1Sprague Dawley ratstype 2 diabetesInhibitorinhibitorinhibit

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HY-12976
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