2. Immunology/Inflammation Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease Cell Cycle/DNA Damage Anti-infection
  3. COX PPAR Orthopoxvirus
  4. Eicosatetraynoic acid

Eicosatetraynoic acid  (Synonyms: ETYA)

Cat. No.: HY-124108 Purity: ≥99.0%
COA Handling Instructions

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Eicosatetraynoic acid (ETYA) is a nonspecific inhibitor of cyclooxygenase and lipoxygenase (ID50=8 μM and 4 μM, respectively). Eicosatetraynoic acid (ETYA) activates PPARα and PPARγ chimeras at 10 μM. Eicosatetraynoic acid specifically interferes with the replication of the cowpox virus both in vivo and in vitro. Eicosatetraynoic acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

For research use only. We do not sell to patients.

Eicosatetraynoic acid Chemical Structure

Eicosatetraynoic acid Chemical Structure

CAS No. : 1191-85-1

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1 mg USD 95 In-stock
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Based on 1 publication(s) in Google Scholar

Eicosatetraynoic acid Related Antibodies

Top Publications Citing Use of Products

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COX COX-1 COX-2 COX-3

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PPARα PPARβ/δ PPARγ PPAR PPARδ

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Description

Eicosatetraynoic acid (ETYA) is a nonspecific inhibitor of cyclooxygenase and lipoxygenase (ID50=8 μM and 4 μM, respectively)[1]. Eicosatetraynoic acid (ETYA) activates PPARα and PPARγ chimeras at 10 μM[2]. Eicosatetraynoic acid specifically interferes with the replication of the cowpox virus both in vivo and in vitro[3]. Eicosatetraynoic acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC50 & Target[2]

COX

8 μM (ID50)

Molecular Weight

296.40

Formula

C20H24O2
CAS No.
Appearance

Solid

Color

Light yellow to brown

SMILES

CCCCCC#CCC#CCC#CCC#CCCCC(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years

*The compound is unstable in solutions, freshly prepared is recommended.

Solvent & Solubility
In Vitro: 

DMSO : 2 mg/mL (6.75 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Ethanol : < 1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3738 mL 16.8691 mL 33.7382 mL
5 mM 0.6748 mL 3.3738 mL 6.7476 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥99.0%

COA (237 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.3738 mL 16.8691 mL 33.7382 mL 84.3455 mL
5 mM 0.6748 mL 3.3738 mL 6.7476 mL 16.8691 mL
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Eicosatetraynoic acid Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Eicosatetraynoic acid1191-85-1ETYACOXPPAROrthopoxvirusCyclooxygenasePeroxisome proliferator-activated receptorsInhibitorinhibitorinhibit

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