ERRα antagonist-2

Cat. No.: HY-144699 Purity: 99.07%: FAQs
Data Sheet
SDS

COA
Handling Instructions Technical Support

ERRα antagonist-2 (Compound 11) is a potential ERRα (estrogen related receptor α) inverse agonist with an IC₅₀ of 0.80 μM. ERRα antagonist-2 suppresses the migration and invasion of the ER-negative MDA-MB-231 cell line. ERRα antagonist-2 inhibits breast cancer growth in vivo.

For research use only. We do not sell to patients.

ERRα antagonist-2 Chemical Structure

CAS No. : 3032965-02-6

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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•Related Small Molecules:

•Related Proteins:

View All Estrogen Receptor/ERR Isoform Specific Products:

View All Isoforms

Estrogen receptor ERα ERβ ERRα ERRβ ERRγ

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

ERRα

0.80 μM (IC₅₀)

Molecular Weight

400.41

Formula

C₁₉H₁₆N₂O₆S

CAS No.

3032965-02-6

Appearance

Solid

Color

Light yellow to yellow

SMILES

COC1=CC=C(C=C1)OC2=CC=CC=C2NS(=O)(C3=CC=C([N+]([O-])=O)C=C3)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 250 mg/mL (624.36 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.4974 mL	12.4872 mL	24.9744 mL
5 mM	0.4995 mL	2.4974 mL	4.9949 mL
10 mM	0.2497 mL	1.2487 mL	2.4974 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

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Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.07%

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Data Sheet (276 KB) SDS (252 KB)

COA (256 KB) HNMR (264 KB) LCMS (95 KB)

Handling Instructions (2659 KB)

References

[1]. Zhipei Gao, et al. The discovery of a novel series of potential ERRα inverse agonists based on p-nitrobenzenesulfonamide template for triple-negative breast cancer in vivo. J Enzyme Inhib Med Chem. 2022 Dec;37(1):125-134. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.4974 mL	12.4872 mL	24.9744 mL	62.4360 mL
	5 mM	0.4995 mL	2.4974 mL	4.9949 mL	12.4872 mL
	10 mM	0.2497 mL	1.2487 mL	2.4974 mL	6.2436 mL
	15 mM	0.1665 mL	0.8325 mL	1.6650 mL	4.1624 mL
	20 mM	0.1249 mL	0.6244 mL	1.2487 mL	3.1218 mL
	25 mM	0.0999 mL	0.4995 mL	0.9990 mL	2.4974 mL
	30 mM	0.0832 mL	0.4162 mL	0.8325 mL	2.0812 mL
	40 mM	0.0624 mL	0.3122 mL	0.6244 mL	1.5609 mL
	50 mM	0.0499 mL	0.2497 mL	0.4995 mL	1.2487 mL
	60 mM	0.0416 mL	0.2081 mL	0.4162 mL	1.0406 mL
	80 mM	0.0312 mL	0.1561 mL	0.3122 mL	0.7805 mL
	100 mM	0.0250 mL	0.1249 mL	0.2497 mL	0.6244 mL