PDIA6 - protein disulfide isomerase family A member 6 Gene

Homo sapiens

Also known as P5; ERP5; TXNDC7

Gene ID: 10130 | Gene type: protein coding

About PDIA6

Cytogenetic location: 2p25.1 Genomic coordinates (GRCh38): 2:10,783,391-10,837,712 (from NCBI)

This gene has 8 transcripts (splice variants), 223 orthologues, 13 paralogues and is associated with 1 phenotype. Ubiquitous expression in thyroid (RPKM 159.7), placenta (RPKM 70.6) and 25 other tissues.

Summary

This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, two catalytically active thioredoxin (TRX) domains, a TRX-like domain, and a C-terminal ER-retention sequence. This protein inhibits the aggregation of misfolded proteins and exhibits both isomerase and chaperone activity. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016]

PDIA6 Products(5)

mRNA	Protein	Name
NM_001282704.2	NP_001269633.1	protein disulfide-isomerase A6 isoform a
NM_001282705.2	NP_001269634.1	protein disulfide-isomerase A6 isoform b
NM_001282706.2	NP_001269635.1	protein disulfide-isomerase A6 isoform c
NM_001282707.2	NP_001269636.1	protein disulfide-isomerase A6 isoform e precursor
NM_005742.4	NP_005733.1	protein disulfide-isomerase A6 isoform d precursor

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15466936	GOA
enables protein-disulfide reductase activity	IDA IDA: Inferred from direct assay	16677074	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in endoplasmic reticulum-Golgi intermediate compartment	IDA IDA: Inferred from direct assay	15308636	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	19995400	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PDIA6 Protein Structure

Thioredoxin

0
100
200
300
400
440 a.a.

Protein Preferred Names

Protein Names

protein disulfide-isomerase A6

ER protein 5

PDIA6 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PDIA6	Q15084	PRDX4	Homo sapiens	Q13162	Enzymatic Study	21057456
Intra	PDIA6	Q15084	HSPA5	Homo sapiens	P11021	Crosslink	30021884
Intra	PDIA6	Q15084	SGTB	Homo sapiens	Q96EQ0	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PDIA6 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71193	PDIA6 Protein, Human (HEK293, His)	Q15084 (L20-L440)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-122895	E64FC26		98.10%	Unkown
HY-122895A	(E/Z)-E64FC26		98.09%	Unkown
HY-RS10271	PDIA6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	PDIA6	VGNC	VGNC:75895
Mus musculus	PDIA6	MGD	MGI:1919103
Bos taurus	PDIA6	VGNC	VGNC:32700
Canis familiaris	PDIA6	VGNC	VGNC:103696
Felis catus	PDIA6	VGNC	VGNC:64086
Rattus norvegicus	PDIA6	RGD	RGD:628688
Others	PDIA6	NCBI

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