2. Gene
  3. SGTB - small glutamine rich tetratricopeptide repeat co-chaperone beta Gene

SGTB - small glutamine rich tetratricopeptide repeat co-chaperone beta Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as SGT2

Gene ID: 54557 | Gene type: protein coding

About SGTB

This gene has 2 transcripts (splice variants), 213 orthologues and 18 paralogues. Broad expression in brain (RPKM 18.1), appendix (RPKM 4.3) and 19 other tissues.

Summary

Predicted to enable molecular adaptor activity. Predicted to be involved in positive regulation of chaperone-mediated protein folding; posttranslational protein targeting to endoplasmic reticulum membrane; and ubiquitin-dependent ERAD pathway. Predicted to be part of TRC complex. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Apr 2022]

SGTB Products(1)

mRNA Protein Name
NM_019072.3 NP_061945.1 small glutamine-rich tetratricopeptide repeat-containing protein beta
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SGTB Protein Structure

TPR_11

TPR_11: TPR repeat (84 - 149)

TPR_1

TPR_1: Tetratricopeptide repeat (154 - 186)

  • 0
  • 100
  • 200
  • 304 a.a.
Protein Preferred Names Protein Names

small glutamine-rich tetratricopeptide repeat-containing protein beta

beta-SGT

SGTB Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra SGTB Q96EQ0 IL6ST Homo sapiens Q17RA0
Y2H Prey Pooling
25416956
Intra SGTB Q96EQ0 IL6ST Homo sapiens Q17RA0
Validated Y2H
25416956
Intra SGTB Q96EQ0 C1QTNF6 Homo sapiens Q9BXI9
Validated Y2H
32296183
Intra SGTB Q96EQ0 PDIA6 Homo sapiens Q15084
Y2H Prey Pooling
32296183
Intra SGTB Q96EQ0 PDIA6 Homo sapiens Q15084
Y2H Array
32296183
Intra SGTB Q96EQ0 TMUB1 Homo sapiens Q9BVT8
Validated Y2H
32296183
Intra SGTB Q96EQ0 CTAG1A Homo sapiens P78358
Y2H Array
32296183
Intra SGTB Q96EQ0 CTAG1A Homo sapiens P78358
Y2H Prey Pooling
32296183
Intra SGTB Q96EQ0 PSORS1C2 Homo sapiens Q9UIG4
Validated Y2H
32296183
Intra SGTB Q96EQ0 KCNE5 Homo sapiens Q9UJ90
Validated Y2H
32296183
Intra SGTB Q96EQ0 RNF170 Homo sapiens Q96K19-5
Y2H Array
32296183
Intra SGTB Q96EQ0 RNF170 Homo sapiens Q96K19-5
Y2H Prey Pooling
32296183
Intra SGTB Q96EQ0 RNF170 Homo sapiens Q96K19-5
Validated Y2H
32296183
Intra SGTB Q96EQ0 TNFRSF19 Homo sapiens Q9NS68-2
Validated Y2H
32296183
Intra SGTB Q96EQ0 EMCN Homo sapiens Q9ULC0-2
Validated Y2H
32296183
Intra SGTB Q96EQ0 HSP90B1 Homo sapiens Q96GW1
Validated Y2H
32296183
Intra SGTB Q96EQ0 SHISA5 Homo sapiens Q8N114-3
Y2H Prey Pooling
32296183
Intra SGTB Q96EQ0 SHISA5 Homo sapiens Q8N114-3
Y2H Array
32296183
Intra SGTB Q96EQ0 COLQ Homo sapiens Q9Y215
Validated Y2H
32296183
Intra SGTB Q96EQ0 a0a1u9x8x8_human Homo sapiens A0A1U9X8X8
Y2H Array
32296183
Intra SGTB Q96EQ0 a0a1u9x8x8_human Homo sapiens A0A1U9X8X8
Y2H Prey Pooling
32296183
Intra SGTB Q96EQ0 C1QTNF5 Homo sapiens Q9BXJ0
Validated Y2H
32296183
Intra SGTB Q96EQ0 C1QTNF5 Homo sapiens Q9BXJ0
Y2H Array
32296183
Intra SGTB Q96EQ0 C1QTNF5 Homo sapiens Q9BXJ0
Y2H Prey Pooling
32296183
Intra SGTB Q96EQ0 PRAP1 Homo sapiens Q96NZ9
Validated Y2H
32296183
Intra SGTB Q96EQ0 PRAP1 Homo sapiens Q96NZ9
Y2H Prey Pooling
32296183
Intra SGTB Q96EQ0 PRAP1 Homo sapiens Q96NZ9
Y2H Array
32296183
Intra SGTB Q96EQ0 SDF2L1 Homo sapiens Q9HCN8
Validated Y2H
32296183
Intra SGTB Q96EQ0 RNF144A Homo sapiens P50876
Y2H Prey Pooling
32296183
Intra SGTB Q96EQ0 RNF144A Homo sapiens P50876
Y2H Array
32296183
Intra SGTB Q96EQ0 FBN1 Homo sapiens P35555
Y2H Array
32296183
Intra SGTB Q96EQ0 FBN1 Homo sapiens P35555
Y2H Prey Pooling
32296183
Intra SGTB Q96EQ0 COMP Homo sapiens P49747
Y2H Array
32296183
Intra SGTB Q96EQ0 COMP Homo sapiens P49747
Y2H Prey Pooling
32296183
Intra SGTB Q96EQ0 TXNDC12 Homo sapiens O95881
Validated Y2H
25416956
Intra SGTB Q96EQ0 OSMR Homo sapiens Q99650
Validated Y2H
32296183
Intra SGTB Q96EQ0 CD99L2 Homo sapiens Q8TCZ2
Y2H Prey Pooling
32296183
Intra SGTB Q96EQ0 CD99L2 Homo sapiens Q8TCZ2
Y2H Array
32296183
Intra SGTB Q96EQ0 ETNK1 Homo sapiens Q9HBU6
Validated Y2H
32296183
Intra SGTB Q96EQ0 SIL1 Homo sapiens Q9H173
Validated Y2H
32296183
Intra SGTB Q96EQ0 IL6R Homo sapiens P08887
Y2H Prey Pooling
32296183
Intra SGTB Q96EQ0 IL6R Homo sapiens P08887
Y2H Array
32296183
Intra SGTB Q96EQ0 SLPI Homo sapiens P03973
Y2H Prey Pooling
32296183
Intra SGTB Q96EQ0 SLPI Homo sapiens P03973
Y2H Array
32296183
Intra SGTB Q96EQ0 UBL4A Homo sapiens P11441
Y2H Prey Pooling
32296183
Intra SGTB Q96EQ0 UBL4A Homo sapiens P11441
Anti Tag CoIP
26496610
Intra SGTB Q96EQ0 UBL4A Homo sapiens P11441
Y2H Array
32296183
Intra SGTB Q96EQ0 PPIB Homo sapiens P23284
Y2H
21516116
Intra SGTB Q96EQ0 FGF21 Homo sapiens Q9NSA1
Validated Y2H
32296183
Intra SGTB Q96EQ0 AGR3 Homo sapiens Q8TD06
Y2H Array
32296183
Intra SGTB Q96EQ0 AGR3 Homo sapiens Q8TD06
Y2H Prey Pooling
32296183
Intra SGTB Q96EQ0 AGR2 Homo sapiens O95994
Y2H Array
32296183
Intra SGTB Q96EQ0 AGR2 Homo sapiens O95994
Y2H Prey Pooling
32296183
Intra SGTB Q96EQ0 EVA1A Homo sapiens Q9H8M9
Validated Y2H
32296183
Intra SGTB Q96EQ0 PRR4 Homo sapiens Q16378
Y2H Array
32296183
Intra SGTB Q96EQ0 PRR4 Homo sapiens Q16378
Y2H Prey Pooling
32296183
Intra SGTB Q96EQ0 EFEMP2 Homo sapiens O95967
Y2H Array
32296183
Intra SGTB Q96EQ0 EFEMP2 Homo sapiens O95967
Y2H Prey Pooling
25416956
Intra SGTB Q96EQ0 EFEMP2 Homo sapiens O95967
Y2H Prey Pooling
32296183
Intra SGTB Q96EQ0 EFEMP2 Homo sapiens O95967
Y2H Array
25416956
Intra SGTB Q96EQ0 TFF1 Homo sapiens P04155
Y2H Array
32296183
Intra SGTB Q96EQ0 TFF1 Homo sapiens P04155
Y2H Prey Pooling
32296183
Intra SGTB Q96EQ0 RAI2 Homo sapiens Q9Y5P3
Y2H Prey Pooling
25416956
Intra SGTB Q96EQ0 GPX7 Homo sapiens Q96SL4
Y2H Prey Pooling
32296183
Intra SGTB Q96EQ0 GPX7 Homo sapiens Q96SL4
Validated Y2H
32296183
Intra SGTB Q96EQ0 GPX7 Homo sapiens Q96SL4
Y2H Array
32296183
Intra SGTB Q96EQ0 SYT4 Homo sapiens Q9H2B2
Validated Y2H
32296183
Intra SGTB Q96EQ0 SYT11 Homo sapiens Q9BT88
Validated Y2H
32296183
Intra SGTB Q96EQ0 CREB3L3 Homo sapiens Q68CJ9
Y2H Array
32296183
Intra SGTB Q96EQ0 CREB3L3 Homo sapiens Q68CJ9
Y2H Prey Pooling
32296183
Intra SGTB Q96EQ0 ABCG4 Homo sapiens Q9H172
Validated Y2H
32296183
Intra SGTB Q96EQ0 ERP29 Homo sapiens P30040
Y2H Prey Pooling
32296183
Intra SGTB Q96EQ0 ERP29 Homo sapiens P30040
Y2H Array
32296183
Intra SGTB Q96EQ0 ECM1 Homo sapiens Q16610
Y2H Array
32296183
Intra SGTB Q96EQ0 ECM1 Homo sapiens Q16610
Y2H Prey Pooling
32296183
Intra SGTB Q96EQ0 RCN1 Homo sapiens Q15293
Y2H Array
32296183
Intra SGTB Q96EQ0 RCN1 Homo sapiens Q15293
Y2H Prey Pooling
32296183
Intra SGTB Q96EQ0 CYB5R1 Homo sapiens Q9UHQ9
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Pituitary Adenoma 1, Multiple Types

Pituitary Adenoma Predisposition

PITA1

Isolated Familial Somatotropinoma

Fis

Ifs

Somatotrophinoma, Familial

Acromegaly Due To Pituitary Adenoma 1

Pagh1

Pituitary Adenoma 1

Somatotropinoma, Familial Isolated

Somatotropic Adenoma

Somatotropinoma

Pituitary Gigantism

Hypophyseal Gigantism

Infantile And Juvenile Forms Of Acromegaly

Acromegaly Due To Pituitary Adenoma

Familial Isolated Pituitary Adenoma

Familial Isolated Somatotropinomas

Familial Somatotrophinoma

Fipa

Pituitary Adenoma, Growth Hormone-Secreting, 1

Gigantism Pituitary

Pituitary Adenoma, Type 1, Multiple Types

Gigantism

Pituitary Adenoma, Familial Isolated

Multiple Gastrointestinal Atresias
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS12817 SGTB Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris SGTB VGNC VGNC:46108
Felis catus SGTB VGNC VGNC:65087
Bos taurus SGTB VGNC VGNC:34554
Macaca mulatta SGTB VGNC VGNC:77296
Mus musculus SGTB MGD MGI:2444615
Rattus norvegicus SGTB RGD RGD:727976