B3GALT5 - beta-1,3-galactosyltransferase 5 Gene

Homo sapiens

Also known as B3T5; GLCT5; B3GalTx; B3GalT-V; beta3Gal-T5; beta-3-Gx-T5; beta-1,3-GalTase 5

Gene ID: 10317 | Gene type: protein coding

About B3GALT5

Cytogenetic location: 21q22.2 Genomic coordinates (GRCh38): 21:39,612,940-39,673,137 (from NCBI)

This gene has 11 transcripts (splice variants), 313 orthologues and 15 paralogues. Biased expression in small intestine (RPKM 5.1), colon (RPKM 4.2) and 3 other tissues.

Summary

This gene encodes a member of a family of membrane-bound glycoproteins. The encoded protein may synthesize type 1 Lewis antigens, which are elevated in gastrointestinal and pancreatic cancers. Alternatively spliced transcript variants using multiple alternate promoters have been observed for this gene. [provided by RefSeq, Sep 2017]

B3GALT5 Products(8)

mRNA	Protein	Name
NM_001278650.2	NP_001265579.1	beta-1,3-galactosyltransferase 5 isoform a
NM_001356336.2	NP_001343265.1	beta-1,3-galactosyltransferase 5 isoform a
NM_001356338.2	NP_001343267.1	beta-1,3-galactosyltransferase 5 isoform a
NM_001356339.2	NP_001343268.1	beta-1,3-galactosyltransferase 5 isoform a
NM_006057.3	NP_006048.1	beta-1,3-galactosyltransferase 5 isoform a
NM_033170.3	NP_149360.1	beta-1,3-galactosyltransferase 5 isoform a
NM_033171.3	NP_149361.1	beta-1,3-galactosyltransferase 5 isoform a
NM_033172.3	NP_149362.2	beta-1,3-galactosyltransferase 5 isoform b

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

B3GALT5 Protein Structure

Galactosyl_T

0
100
200
310 a.a.

Protein Preferred Names

Protein Names

beta-1,3-galactosyltransferase 5

UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5

B3GALT5 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	B3GALT5	Q9Y2C3	CLEC2D	Homo sapiens	Q9UHP7-3	Y2H Array	32296183
Intra	B3GALT5	Q9Y2C3	CLEC2D	Homo sapiens	Q9UHP7-3	Y2H Prey Pooling	32296183
Intra	B3GALT5	Q9Y2C3	DEFB103A	Homo sapiens	P81534	Y2H Array	32296183
Intra	B3GALT5	Q9Y2C3	DEFB103A	Homo sapiens	P81534	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant B3GALT5 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76738	B3GALT5 Protein, Human (HEK293, Fc)	Q9Y2C3 (N29-V310)	≥95%
HY-P76739	B3GALT5 Protein, Human (sf9, His)	Q9Y2C3 (N29-V310)	≥95%

Related Diseases

Diseases

Alias

Pancreatic Cancer

Pancreatic Carcinoma	Carcinoma Of Pancreas
Familial Pancreatic Carcinoma	Pancreatic Neoplasm
Pancreatic Carcinoma, Familial	Malignant Neoplasm Of Pancreas
Pancreatic Acinar Carcinoma	Pancreatic Tumor
Familial Pancreatic Cancer	Neoplasm Of The Pancreas
Cancer Of The Pancreas	Pancreatic Carcinoma, Somatic
Pancreatic Cancer, Somatic	Ca Body Of Pancreas
Ca Head Of Pancreas	Ca Tail Of Pancreas
Malignant Neoplasm Of Body Of Pancreas	Malignant Neoplasm Of Head Of Pancreas
Malignant Neoplasm Of Tail Of Pancreas	Pancreas Neoplasm
Exocrine Cancer	Exocrine Pancreas Carcinoma
Hereditary Pancreatic Cancer	Hereditary Pancreatic Carcinoma
PNCA	Pancreatic Cancer, Susceptibility To
Carcinoma Of Head Of Pancreas	Pancreatic Neoplasms
Pancreatic Tumors	Cancer, Pancreatic
Cancer Of Pancreas	Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01305	B3GALT5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	B3GALT5	VGNC	VGNC:56202
Canis familiaris	B3GALT5	VGNC	VGNC:38336
Macaca mulatta	B3GALT5	VGNC	VGNC:70206
Felis catus	B3GALT5	VGNC	VGNC:68955
Rattus norvegicus	B3GALT5	RGD	RGD:1306727
Mus musculus	B3GALT5	MGD	MGI:2136878
Others	B3GALT5	NCBI

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