TBC1D8 - TBC1 domain family member 8 Gene

Homo sapiens

Also known as AD3; VRP; HBLP1; GRAMD8; TBC1D8A

Gene ID: 11138 | Gene type: protein coding

About TBC1D8

This gene has 10 transcripts (splice variants), 197 orthologues and 45 paralogues. Ubiquitous expression in testis (RPKM 11.3), heart (RPKM 10.6) and 25 other tissues.

Summary

Predicted to enable GTPase activator activity. Predicted to be involved in activation of GTPase activity and intracellular protein transport. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Apr 2022]

TBC1D8 Products(2)

mRNA	Protein	Name
NM_001102426.3	NP_001095896.1	TBC1 domain family member 8 isoform 2
NM_001330348.2	NP_001317277.1	TBC1 domain family member 8 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	Reference	Source
NOT involved in regulation of cilium assembly	IMP IMP: Inferred from mutant phenotype	17646400	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TBC1D8 Protein Structure

GRAM

RabGAP-TBC

0
200
400
600
800
1000
1140 a.a.

Protein Preferred Names

Protein Names

TBC1 domain family member 8

BUB2-like protein 1

TBC1D8 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TBC1D8	O95759	TRAF1	Homo sapiens	Q13077	Validated Y2H	32296183
Intra	TBC1D8	O95759	TRAF1	Homo sapiens	Q13077	Y2H Prey Pooling	32296183
Intra	TBC1D8	O95759	TRAF1	Homo sapiens	Q13077	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Autosomal Dominant Nonsyndromic Deafness 78

Dfna78

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14247	TBC1D8 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS14248	TBC1D8B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	TBC1D8	VGNC	VGNC:65989
Canis familiaris	TBC1D8	VGNC	VGNC:47151
Bos taurus	TBC1D8	VGNC	VGNC:35645
Macaca mulatta	TBC1D8	VGNC	VGNC:78153
Rattus norvegicus	TBC1D8	RGD	RGD:1595491
Mus musculus	TBC1D8	MGD	MGI:1927225

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