Ripk2 - receptor (TNFRSF)-interacting serine-threonine kinase 2 Gene

Mus musculus

Also known as CCK; RICK; RIP2; CARD3; CARDIAK; D4Bwg0615e; 2210420D18Rik

Gene ID: 192656 | Gene type: protein coding

About Ripk2

Chromosome 4: 16,122,733-16,163,647 reverse strand.GRCm39:CM000997.3

This gene has 2 transcripts (splice variants), 207 orthologues, 23 paralogues and is associated with 9 phenotypes. Ubiquitous expression in ovary adult (RPKM 9.1), adrenal adult (RPKM 8.) and 28 other tissues.

Summary

This gene encodes a member of the receptor-interacting protein family of serine/threonine protein kinases. The encoded protein contains a C-terminal Caspase activation and recruitment domain, and is a component of signaling complexes in both the innate and adaptive immune pathways. It is a potent activator of nuclear factor kappa B and inducer of Apoptosis in response to various stimuli. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2016]

Ripk2 Products(2)

mRNA	Protein	Name
NM_001329751.1	NP_001316680.1	receptor-interacting serine/threonine-protein kinase 2 isoform 2
NM_138952.4	NP_620402.1	receptor-interacting serine/threonine-protein kinase 2 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	19473975	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of CD4-positive, alpha-beta T cell proliferation	IMP IMP: Inferred from mutant phenotype	11894097	MGI
acts upstream of ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	18261938	MGI
acts upstream of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	11894098	MGI
acts upstream of JNK cascade	IMP IMP: Inferred from mutant phenotype	11894097	MGI
acts upstream of or within T cell proliferation	IMP IMP: Inferred from mutant phenotype	14638696	MGI
acts upstream of or within T cell receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	11894098	MGI
involved in T cell receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	21469090	MGI
involved in adaptive immune response	IMP IMP: Inferred from mutant phenotype	21469090	MGI
involved in canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	21469090	MGI
acts upstream of or within cellular response to lipopolysaccharide	IMP IMP: Inferred from mutant phenotype	11894097	MGI
acts upstream of or within cellular response to lipoteichoic acid	IMP IMP: Inferred from mutant phenotype	11894098	MGI
involved in cellular response to muramyl dipeptide	IDA IDA: Inferred from direct assay	17947236	MGI
acts upstream of or within cellular response to peptidoglycan	IMP IMP: Inferred from mutant phenotype	11894098	MGI
acts upstream of chemokine production	IMP IMP: Inferred from mutant phenotype	11894098	MGI
acts upstream of cytokine-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	11894097	MGI
acts upstream of or within defense response to Gram-positive bacterium	IMP IMP: Inferred from mutant phenotype	11894097	MGI
acts upstream of immature T cell proliferation in thymus	IMP IMP: Inferred from mutant phenotype	11894098	MGI
involved in innate immune response	IMP IMP: Inferred from mutant phenotype	21469090	MGI
acts upstream of interleukin-2 production	IMP IMP: Inferred from mutant phenotype	11894098	MGI
acts upstream of interleukin-6 production	IMP IMP: Inferred from mutant phenotype	11894098	MGI
acts upstream of or within lipopolysaccharide-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	11894098	MGI
acts upstream of macrophage cytokine production	IMP IMP: Inferred from mutant phenotype	11894098	MGI
acts upstream of or within nucleotide-binding oligomerization domain containing 1 signaling pathway	IMP IMP: Inferred from mutant phenotype	11894098	MGI
involved in nucleotide-binding oligomerization domain containing 2 signaling pathway	IDA IDA: Inferred from direct assay	17947236	MGI
acts upstream of or within nucleotide-binding oligomerization domain containing 2 signaling pathway	IMP IMP: Inferred from mutant phenotype	11894098	MGI
acts upstream of or within positive regulation of CD4-positive, alpha-beta T cell proliferation	IMP IMP: Inferred from mutant phenotype	11894097	MGI
acts upstream of or within positive regulation of ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	18261938	MGI
acts upstream of or within positive regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	11894098	MGI
acts upstream of or within positive regulation of JNK cascade	IMP IMP: Inferred from mutant phenotype	11894097	MGI
acts upstream of or within positive regulation of NF-kappaB transcription factor activity	IMP IMP: Inferred from mutant phenotype	14638696	MGI
involved in positive regulation of NF-kappaB transcription factor activity	IMP IMP: Inferred from mutant phenotype	21887730	MGI
acts upstream of or within positive regulation of T-helper 1 cell differentiation	IMP IMP: Inferred from mutant phenotype	11894097	MGI
acts upstream of or within positive regulation of T-helper 1 type immune response	IMP IMP: Inferred from mutant phenotype	11894097	MGI
acts upstream of or within positive regulation of apoptotic process	IDA IDA: Inferred from direct assay	14663141	MGI
involved in positive regulation of canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	17947236	MGI
involved in positive regulation of canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	11894097	MGI
acts upstream of or within positive regulation of chemokine production	IMP IMP: Inferred from mutant phenotype	11894098	MGI
acts upstream of or within positive regulation of cytokine-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	11894097	MGI
acts upstream of or within positive regulation of immature T cell proliferation in thymus	IMP IMP: Inferred from mutant phenotype	11894098	MGI
acts upstream of or within positive regulation of interleukin-2 production	IMP IMP: Inferred from mutant phenotype	11894098	MGI
acts upstream of or within positive regulation of interleukin-6 production	IMP IMP: Inferred from mutant phenotype	11894098	MGI
involved in positive regulation of interleukin-6 production	IMP IMP: Inferred from mutant phenotype	21887730	MGI
acts upstream of or within positive regulation of macrophage cytokine production	IMP IMP: Inferred from mutant phenotype	11894098	MGI
acts upstream of or within positive regulation of stress-activated MAPK cascade	IMP IMP: Inferred from mutant phenotype	11894097	MGI
acts upstream of or within positive regulation of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	11894098	MGI
involved in positive regulation of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	21887730	MGI
acts upstream of or within positive regulation of type II interferon production	IMP IMP: Inferred from mutant phenotype	11894097	MGI
acts upstream of or within positive regulation of xenophagy	IMP IMP: Inferred from mutant phenotype	22033934	MGI
NOT acts upstream of or within regulation of cysteine-type endopeptidase activity involved in apoptotic process	IMP IMP: Inferred from mutant phenotype	15190255	MGI
acts upstream of or within response to exogenous dsRNA	IMP IMP: Inferred from mutant phenotype	11894098	MGI
acts upstream of or within response to interleukin-1	IMP IMP: Inferred from mutant phenotype	11894098	MGI
acts upstream of or within response to interleukin-12	IMP IMP: Inferred from mutant phenotype	11894097	MGI
acts upstream of or within response to interleukin-18	IMP IMP: Inferred from mutant phenotype	11894097	MGI
acts upstream of stress-activated MAPK cascade	IMP IMP: Inferred from mutant phenotype	11894097	MGI
acts upstream of or within toll-like receptor 4 signaling pathway	IMP IMP: Inferred from mutant phenotype	11894098	MGI
acts upstream of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	11894098	MGI
acts upstream of type II interferon production	IMP IMP: Inferred from mutant phenotype	11894097	MGI
acts upstream of xenophagy	IMP IMP: Inferred from mutant phenotype	22033934	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ripk2 Protein Structure

STKc_RIP2

CARD_RIP2_CARD3

0
100
200
300
400
500
539 a.a.

Protein Preferred Names

Protein Names

receptor-interacting serine/threonine-protein kinase 2

tyrosine-protein kinase RIPK2

Ripk2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Ripk2	Q547H1	Rps27a	Mus musculus	P62991	Anti Tag CoIP	18079694

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Phase
HY-112038A	GSK2983559	Inhibitor	98.82%	Phase 1
HY-19764	GSK2983559 active metabolite	Inhibitor	98.81%	Phase 1
HY-112038	GSK2983559 free acid	Inhibitor	99.90%	Phase 1

Pre-clinical Phase

Bioactive Molecules (11)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-18937	WEHI-345	Inhibitor	99.31%	Unkown
HY-111866	PROTAC RIPK degrader-2	Inhibitor	99.48%	Unkown
HY-19628	OD36	Inhibitor	98.70%	Unkown
HY-115630	cRIPGBM chloride		99.73%	Unkown
HY-122665	HTH-01-091	Inhibitor	98.64%	Unkown
HY-100112	WEHI-345 analog	Inhibitor	98.41%	Unkown
HY-125466	cRIPGBM		/	Unkown
HY-136010	RIP2 Kinase Inhibitor 4	Inhibitor	/	Unkown
HY-147235	RIPK2-IN-2	Inhibitor	/	Unkown
HY-159965	NOD1-RIPK2-IN-1	Inhibitor	/	Unkown
HY-19628A	OD36 hydrochloride	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ripk2	NCBI	NCBI:8767

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