2. Gene
  3. Ripk2 - receptor (TNFRSF)-interacting serine-threonine kinase 2 Gene

Ripk2 - receptor (TNFRSF)-interacting serine-threonine kinase 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as CCK; RICK; RIP2; CARD3; CARDIAK; D4Bwg0615e; 2210420D18Rik

Gene ID: 192656 | Gene type: protein coding

About Ripk2

Chromosome 4: 16,122,733-16,163,647 reverse strand.GRCm39:CM000997.3

This gene has 2 transcripts (splice variants), 207 orthologues, 23 paralogues and is associated with 9 phenotypes. Ubiquitous expression in ovary adult (RPKM 9.1), adrenal adult (RPKM 8.) and 28 other tissues.

Summary

This gene encodes a member of the receptor-interacting protein family of serine/threonine protein kinases. The encoded protein contains a C-terminal Caspase activation and recruitment domain, and is a component of signaling complexes in both the innate and adaptive immune pathways. It is a potent activator of nuclear factor kappa B and inducer of Apoptosis in response to various stimuli. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2016]

Ripk2 Products(2)

mRNA Protein Name
NM_001329751.1 NP_001316680.1 receptor-interacting serine/threonine-protein kinase 2 isoform 2
NM_138952.4 NP_620402.1 receptor-interacting serine/threonine-protein kinase 2 isoform 1

Ripk2 Protein Structure

STKc_RIP2

STKc_RIP2: cd14026 (19 - 302)

CARD_RIP2_CARD3

CARD_RIP2_CARD3: cd08786 (436 - 521)

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  • 539 a.a.
Protein Preferred Names Protein Names

receptor-interacting serine/threonine-protein kinase 2

tyrosine-protein kinase RIPK2

Related Agents

Clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-112038A GSK2983559 Inhibitor 98.82% Phase 1
HY-19764 GSK2983559 active metabolite Inhibitor 98.81% Phase 1
HY-112038 GSK2983559 free acid Inhibitor 99.90% Phase 1
Pre-clinical Phase
Bioactive Molecules (9)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-18937 WEHI-345 Inhibitor 99.31% Unkown
HY-111866 PROTAC RIPK degrader-2 Inhibitor 99.48% Unkown
HY-19628 OD36 Inhibitor 98.70% Unkown
HY-100112 WEHI-345 analog Inhibitor 98.41% Unkown
HY-115630 cRIPGBM chloride 99.73% Unkown
HY-125466 cRIPGBM / Unkown
HY-136010 RIP2 Kinase Inhibitor 4 Inhibitor / Unkown
HY-147235 RIPK2-IN-2 Inhibitor / Unkown
HY-19628A OD36 hydrochloride Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ripk2 NCBI NCBI:8767