2. Apoptosis
  3. RIP kinase
  4. WEHI-345 analog

WEHI-345 analog is the analog of WEHI-345. WEHI-345 is a potent and selective RIPK2 kinase inhibitor with an IC50 of 0.13 μM, which delays RIPK2 ubiquitylation and NF-κB activation on oligomerization domain (NOD) stimulation.

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WEHI-345 analog Chemical Structure

WEHI-345 analog Chemical Structure

CAS No. : 1354825-62-9

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 384 In-stock
Solution
10 mM * 1 mL in DMSO USD 384 In-stock
Solid
5 mg USD 420 In-stock
10 mg USD 600 In-stock
25 mg USD 1200 In-stock
50 mg USD 1920 In-stock
100 mg   Get quote  
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Based on 1 publication(s) in Google Scholar

WEHI-345 analog Related Antibodies

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Description

WEHI-345 analog is the analog of WEHI-345. WEHI-345 is a potent and selective RIPK2 kinase inhibitor with an IC50 of 0.13 μM, which delays RIPK2 ubiquitylation and NF-κB activation on oligomerization domain (NOD) stimulation[1].

IC50 & Target

RIPK2

 

Molecular Weight

415.49

Formula

C23H25N7O
CAS No.
Appearance

Solid

Color

White to gray

SMILES

O=C(C1=NC=CC=C1C)NCC(C)(N2N=C(C3=CC=C(C)C=C3)C4=C(N)N=CN=C42)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 30 mg/mL (72.20 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4068 mL 12.0340 mL 24.0680 mL
5 mM 0.4814 mL 2.4068 mL 4.8136 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4068 mL 12.0340 mL 24.0680 mL 60.1699 mL
5 mM 0.4814 mL 2.4068 mL 4.8136 mL 12.0340 mL
10 mM 0.2407 mL 1.2034 mL 2.4068 mL 6.0170 mL
15 mM 0.1605 mL 0.8023 mL 1.6045 mL 4.0113 mL
20 mM 0.1203 mL 0.6017 mL 1.2034 mL 3.0085 mL
25 mM 0.0963 mL 0.4814 mL 0.9627 mL 2.4068 mL
30 mM 0.0802 mL 0.4011 mL 0.8023 mL 2.0057 mL
40 mM 0.0602 mL 0.3008 mL 0.6017 mL 1.5042 mL
50 mM 0.0481 mL 0.2407 mL 0.4814 mL 1.2034 mL
60 mM 0.0401 mL 0.2006 mL 0.4011 mL 1.0028 mL
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WEHI-345 analog Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

WEHI-3451354825-62-9WEHI345WEHI 345RIP kinaseReceptor-interacting protein kinasesRIPKInhibitorinhibitorinhibit

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