GSK2983559 free acid

Name: GSK2983559 free acid
Brand: MedChemExpress
SKU: HY-112038
Rating: 5.0 (1 reviews)

Cat. No.: HY-112038 Purity: 99.90%: FAQs
Data Sheet SDS COA Handling Instructions

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GSK2983559 free acid (compound 3) is an orally active and potent receptor interacting protein 2 (RIP2) kinase inhibitor. GSK2983559 free acid can block many proinflammatory cytokine responses in vivo and in human inflammatory bowel disease explant samples.

For research use only. We do not sell to patients.

GSK2983559 free acid Chemical Structure

CAS No. : 1579965-12-0

Size	Price	Stock	Quantity
5 mg	USD 98	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 149	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 268	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 389	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 565	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of GSK2983559 free acid:

GSK2983559 active metabolite In-stock
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View All RIP kinase Isoform Specific Products:

View All Isoforms

RIPK1 RIPK2 RIPK3

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target^[1]

RIPK2

Cellular Effect

Cell Line	Type	Value	Description	References
THP-1	IC₅₀	1.34 nM Compound: 5; GSK2983559	Antiinflammatory activity in MDP-stimulated IL-8 production in human THP-1 cells pretreated for 2 hrs followed by MDP stimulation for 6 hrs Antiinflammatory activity in MDP-stimulated IL-8 production in human THP-1 cells pretreated for 2 hrs followed by MDP stimulation for 6 hrs	[PMID: 36058467]

In Vitro

GSK2983559 (1-1024 nM; 2 h) blocks MDP-induced IL-8 in THP-1 cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[2]

Cell Line:	THP-1 cells
Concentration:	1-1024 nM
Incubation Time:	2 hours
Result:	Inhibited IL-8 production with an IC₅₀ of 1.34 nM.

In Vivo

GSK2983559 (oral gavage; 3 and 10 mg/kg; once) inhibits effectively MDP-induced IL-6 in mouse^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	C57BL/6 mice (female) injected with MDP (100 μg)^[2]
Dosage:	3 and 10 mg/kg
Administration:	Oral gavage; 3 and 10 mg/kg; once
Result:	Suppressed serum IL-6 levels in a dose-dependent manner.

Clinical Trial

Molecular Weight

538.53

Formula

C₂₁H₂₃N₄O₇PS₂

CAS No.

1579965-12-0

Appearance

Solid

Color

Light yellow to yellow

SMILES

CC(C)(C)S(C(C(OCCOP(O)(O)=O)=CC1=NC=N2)=CC1=C2NC3=CC(N=CS4)=C4C=C3)(=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Solvent & Solubility

In Vitro:

DMSO : 5 mg/mL (9.28 mM; ultrasonic and warming and heat to 80°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.8569 mL	9.2845 mL	18.5691 mL
5 mM	0.3714 mL	1.8569 mL	3.7138 mL
10 mM	---	---	---

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.90%

Select Batch:

Data Sheet (277 KB) SDS (252 KB)

COA (254 KB) LCMS (267 KB)

Handling Instructions (2659 KB)

References

[1]. Haile PA, et al. Discovery of a First-in-Class Receptor Interacting Protein 2 (RIP2) Kinase Specific Clinical Candidate, 2-((4-(Benzo[d]thiazol-5-ylamino)-6-(tert-butylsulfonyl)quinazolin-7-yl)oxy)ethyl Dihydrogen Phosphate, for the Treatment of Inflammat [Content Brief]

[2]. Shuwei Wu, et al. Design, synthesis, and structure-activity relationship of novel RIPK2 inhibitors. Bioorg Med Chem Lett. 2022 Sep 2;75:128968. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.8569 mL	9.2845 mL	18.5691 mL	46.4227 mL
DMSO	5 mM	0.3714 mL	1.8569 mL	3.7138 mL	9.2845 mL