Sema4c - sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C Gene

Mus musculus

Also known as Semaf; Semai; sema I; Semacl1; M-Sema F

Gene ID: 20353 | Gene type: protein coding

About Sema4c

Summary

This gene encodes a member of the semaphorin family of proteins that have diverse functions in neuronal development, heart morphogenesis, vascular growth, tumor progression and immune cell regulation. Lack of the encoded protein in some mice causes exencephaly resulting in neonatal lethality. Mice that bypass exencephaly show no obvious behavioral defects but display distinct pigmentation defects. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2015]

Sema4c Products(6)

mRNA	Protein	Name
NM_001126047.3	NP_001119519.1	semaphorin-4C precursor
NM_001304329.1	NP_001291258.1	semaphorin-4C precursor
NM_001304330.1	NP_001291259.1	semaphorin-4C precursor
NM_001126047.3	NP_001119519.1	semaphorin-4C precursor
NM_001304329.1	NP_001291258.1	semaphorin-4C precursor
NM_001304330.1	NP_001291259.1	semaphorin-4C precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	10318831	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in cell migration in hindbrain	IMP IMP: Inferred from mutant phenotype	21122816	MGI
involved in cerebellum development	IMP IMP: Inferred from mutant phenotype	21122816	MGI
involved in muscle cell differentiation	IMP IMP: Inferred from mutant phenotype	15811348	MGI
involved in neural tube closure	IMP IMP: Inferred from mutant phenotype	21122816	MGI
involved in regulation of postsynapse assembly	IDA IDA: Inferred from direct assay	31444474	MGI
involved in regulation of postsynapse assembly	IMP IMP: Inferred from mutant phenotype	31444474	MGI
involved in semaphorin-plexin signaling pathway	IMP IMP: Inferred from mutant phenotype	21122816	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	11134026	MGI
is active in glutamatergic synapse	IEP IEP: Inferred from expression pattern	11134026	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	31444474	MGI
located in postsynaptic density	IDA IDA: Inferred from direct assay	11134026	MGI
is active in postsynaptic density membrane	IDA IDA: Inferred from direct assay	11134026	MGI
is active in postsynaptic density membrane	IEP IEP: Inferred from expression pattern	11134026	MGI
located in synaptic vesicle membrane	IDA IDA: Inferred from direct assay	11134026	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

semaphorin-4C

semaphorin I

semaphorin-C-like 1

Recombinant Sema4c Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71285	Semaphorin-4C/SEMA4C Protein, Mouse (HEK293, Fc)	Q64151 (A21-G664）	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12659	SEMA4C Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Sema4c	NCBI	NCBI:54910

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