SEMA4C - semaphorin 4C Gene

Homo sapiens

Also known as SEMAF; SEMAI; SEMACL1; M-SEMA-F

Gene ID: 54910 | Gene type: protein coding

About SEMA4C

Cytogenetic location: 2q11.2 Genomic coordinates (GRCh38): 2:96,859,718-96,870,830 (from NCBI)

This gene has 6 transcripts (splice variants), 201 orthologues and 19 paralogues. Ubiquitous expression in placenta (RPKM 20.2), endometrium (RPKM 13.1) and 24 other tissues.

Summary

Predicted to enable chemorepellent activity and semaphorin receptor binding activity. Involved in muscle cell differentiation and positive regulation of stress-activated MAPK cascade. Located in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]

SEMA4C Products(1)

mRNA	Protein	Name
NM_017789.5	NP_060259.4	semaphorin-4C precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in muscle cell differentiation	IDA IDA: Inferred from direct assay	17498836	GOA
involved in positive regulation of stress-activated MAPK cascade	IDA IDA: Inferred from direct assay	17498836	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SEMA4C Protein Structure

Sema

PSI

0
200
400
600
833 a.a.

Protein Preferred Names

Protein Names

semaphorin-4C

M-Sema F

SEMA4C Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SEMA4C	Q9C0C4	KRT40	Homo sapiens	Q6A162	Validated Y2H	25416956
Intra	SEMA4C	Q9C0C4	KRT40	Homo sapiens	Q6A162	Y2H Array	25416956
Intra	SEMA4C	Q9C0C4	CACNA1C	Homo sapiens	Q13936	Anti Bait CoIP	37207277
Intra	SEMA4C	Q9C0C4	KRT34	Homo sapiens	O76011	Y2H Prey Pooling	32296183
Intra	SEMA4C	Q9C0C4	KRT34	Homo sapiens	O76011	Y2H Array	32296183
Intra	SEMA4C	Q9C0C4	HCN1	Homo sapiens	O60741	Anti Bait CoIP	37207277
Intra	SEMA4C	Q9C0C4	NOTCH2NLC	Homo sapiens	P0DPK4	Y2H Array	32296183
Intra	SEMA4C	Q9C0C4	NOTCH2NLC	Homo sapiens	P0DPK4	Y2H Prey Pooling	32296183
Intra	SEMA4C	Q9C0C4	KRTAP6-3	Homo sapiens	Q3LI67	Y2H Prey Pooling	32296183
Intra	SEMA4C	Q9C0C4	KRTAP6-3	Homo sapiens	Q3LI67	Y2H Array	32296183
Intra	SEMA4C	Q9C0C4	PNMA1	Homo sapiens	Q8ND90	Y2H Prey Pooling	32296183
Intra	SEMA4C	Q9C0C4	PNMA1	Homo sapiens	Q8ND90	Y2H Array	32296183
Intra	SEMA4C	Q9C0C4	PNMA1	Homo sapiens	Q8ND90	Y2H Prey Pooling	25416956
Intra	SEMA4C	Q9C0C4	KRT27	Homo sapiens	Q7Z3Y8	Y2H Prey Pooling	32296183
Intra	SEMA4C	Q9C0C4	KRT27	Homo sapiens	Q7Z3Y8	Y2H Array	32296183
Intra	SEMA4C	Q9C0C4	KRT16	Homo sapiens	P08779	Y2H Prey Pooling	32296183
Intra	SEMA4C	Q9C0C4	KRT16	Homo sapiens	P08779	Y2H Array	32296183
Intra	SEMA4C	Q9C0C4	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183
Intra	SEMA4C	Q9C0C4	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183
Intra	SEMA4C	Q9C0C4	HSF2BP	Homo sapiens	O75031	Y2H Prey Pooling	32296183
Intra	SEMA4C	Q9C0C4	HSF2BP	Homo sapiens	O75031	Y2H Array	32296183
Intra	SEMA4C	Q9C0C4	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	SEMA4C	Q9C0C4	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	SEMA4C	Q9C0C4	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	SEMA4C	Q9C0C4	USHBP1	Homo sapiens	Q8N6Y0	Y2H Prey Pooling	32296183
Intra	SEMA4C	Q9C0C4	NOTCH2NLA	Homo sapiens	Q7Z3S9	Y2H Prey Pooling	25416956
Intra	SEMA4C	Q9C0C4	NOTCH2NLA	Homo sapiens	Q7Z3S9	Y2H Array	25416956
Intra	SEMA4C	Q9C0C4	RCHY1	Homo sapiens	Q96PM5	Validated Y2H	25416956
Intra	SEMA4C	Q9C0C4	KRT31	Homo sapiens	Q15323	Y2H Prey Pooling	25416956
Intra	SEMA4C	Q9C0C4	KRT31	Homo sapiens	Q15323	Y2H Prey Pooling	32296183
Intra	SEMA4C	Q9C0C4	KRT31	Homo sapiens	Q15323	Y2H Array	25416956
Intra	SEMA4C	Q9C0C4	KRT31	Homo sapiens	Q15323	Y2H Array	32296183
Intra	SEMA4C	Q9C0C4	PEX1	Homo sapiens	O43933	Validated Y2H	32814053
Intra	SEMA4C	Q9C0C4	PEX1	Homo sapiens	O43933	Y2H Pooling	32814053
Intra	SEMA4C	Q9C0C4	PEX1	Homo sapiens	O43933	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Cri-Du-Chat Syndrome

5p Deletion Syndrome	5p Partial Monosomy Syndrome
Monosomy 5p	Cat Cry Syndrome
Chromosome 5p Deletion Syndrome	Cri Du Chat Syndrome
5p- Syndrome	5p Minus Syndrome
Chromosome 5p- Syndrome	Chromosome 5 Short Arm Deletion Syndrome
Chromosome 5p Deletion	Deletion 5p
Cri Du Chat	5p Partial Deletion Syndrome
Partial Deletion Of Short Arm Of Chromosome 5 Syndrome

Kallmann Syndrome

Hypogonadism With Anosmia	Kallman'S Syndrome
Anosmic Hypogonadism	Anosmic Idiopathic Hypogonadotropic Hypogonadism
Hypogonadotropic Hypogonadism And Anosmia	Hypogonadotropic Hypogonadism-Anosmia Syndrome
Olfacto-Genital Pathological Sequence	Familial Hypogonadism With Anosmia
Kallman Syndrome	Dysplasia Olfactogenitalis Of De Morsier
Kallmann'S Syndrome	Congenital Hypogonadotropic Hypogonadism With Anosmia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12659	SEMA4C Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	SEMA4C	VGNC	VGNC:103862
Canis familiaris	SEMA4C	VGNC	VGNC:45996
Rattus norvegicus	SEMA4C	RGD	RGD:1562837
Mus musculus	SEMA4C	MGD	MGI:109252
Bos taurus	SEMA4C	VGNC	VGNC:34435
Felis catus	SEMA4C	VGNC	VGNC:64994
Others	SEMA4C	NCBI

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