ERH - ERH mRNA splicing and mitosis factor Gene

Homo sapiens

Also known as DROER

Gene ID: 2079 | Gene type: protein coding

About ERH

Cytogenetic location: 14q24.1 Genomic coordinates (GRCh38): 14:69,380,128-69,398,299 (from NCBI)

This gene has 4 transcripts (splice variants) and 345 orthologues. Ubiquitous expression in colon (RPKM 61.2), kidney (RPKM 56.3) and 25 other tissues.

Summary

Enables methyl-CpG binding activity. Predicted to be involved in pyrimidine nucleoside metabolic process. Located in midbody and nucleus. Part of methylosome. [provided by Alliance of Genome Resources, Apr 2022]

ERH Products(1)

mRNA	Protein	Name
NM_004450.3	NP_004441.1	enhancer of rudimentary homolog

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables methyl-CpG binding	IDA IDA: Inferred from direct assay	25284789	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21516116	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of methylosome	IDA IDA: Inferred from direct assay	25284789	GOA
located in midbody	IDA IDA: Inferred from direct assay	15166316	GOA
located in nucleus	IDA IDA: Inferred from direct assay	23145069	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ERH Protein Structure

0
104 a.a.

Protein Preferred Names

Protein Names

enhancer of rudimentary homolog

ERH Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ERH	P84090	CENPH	Homo sapiens	Q9H3R5	Validated Y2H	32296183
Intra	ERH	P84090	TASOR2	Homo sapiens	Q5VWN6-2	Validated Y2H	25416956
Intra	ERH	P84090	TASOR2	Homo sapiens	Q5VWN6-2	Y2H Prey Pooling	25416956
Intra	ERH	P84090	CHTOP	Homo sapiens	Q9Y3Y2-3	Validated Y2H	32296183
Intra	ERH	P84090	CHTOP	Homo sapiens	Q9Y3Y2-3	Y2H Prey Pooling	32296183
Intra	ERH	P84090	CHTOP	Homo sapiens	Q9Y3Y2-3	Y2H Array	32296183
Intra	ERH	P84090	CHTOP	Homo sapiens	Q9Y3Y2	Validated Y2H	25416956
Intra	ERH	P84090	CHTOP	Homo sapiens	Q9Y3Y2	Anti Tag CoIP	33961781
Intra	ERH	P84090	SNRPD3	Homo sapiens	P62318	Anti Bait CoIP	23236152
Intra	ERH	P84090	SNRPD3	Homo sapiens	P62318	Anti Tag CoIP	23236152
Intra	ERH	P84090	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183
Intra	ERH	P84090	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183
Intra	ERH	P84090	ATP6V0C	Homo sapiens	P27449	Y2H Prey Pooling	32296183
Intra	ERH	P84090	ATP6V0C	Homo sapiens	P27449	Y2H Array	32296183
Intra	ERH	P84090	UPRT	Homo sapiens	Q96BW1	Validated Y2H	32296183
Intra	ERH	P84090	TASOR2	Homo sapiens	Q5VWN6	Anti Tag CoIP	33961781
Intra	ERH	P84090	TASOR2	Homo sapiens	Q5VWN6	Validated Y2H	32296183
Intra	ERH	P84090	TASOR2	Homo sapiens	Q5VWN6	Y2H Prey Pooling	32296183
Intra	ERH	P84090	TASOR2	Homo sapiens	Q5VWN6	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ERH Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74169	ERH Protein, Human (N-His)	P84090 (M1-K104)	≥95%

Related Diseases

Diseases

Alias

Acute Maxillary Sinusitis

Acute Antritis

Primary Progressive Multiple Sclerosis

Ppms	Primary-Progressive Ms
Multiple Sclerosis, Primary Progressive

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N8589	(-)-Epiafzelechin-3-O-gallate		/	Unkown
HY-RS04495	ERH Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	ERH	VGNC	VGNC:72428
Felis catus	ERH	VGNC	VGNC:61942
Mus musculus	ERH	MGD	MGI:108089
Bos taurus	ERH	VGNC	VGNC:28581
Canis familiaris	ERH	VGNC	VGNC:40453
Rattus norvegicus	ERH	RGD	RGD:1595409
Others	ERH	NCBI

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