2. Gene
  3. ATP6V0C - ATPase H+ transporting V0 subunit c Gene

ATP6V0C - ATPase H+ transporting V0 subunit c Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as ATPL; VATL; VPPC; Vma3; ATP6C; ATP6L

Gene ID: 527 | Gene type: protein coding

About ATP6V0C

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:2,513,726-2,520,218 (from NCBI)

This gene has 4 transcripts (splice variants), 294 orthologues, 1 paralogue and is associated with 1 phenotype. Ubiquitous expression in kidney (RPKM 126.5), brain (RPKM 117.6) and 25 other tissues.

Summary

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit Enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. This gene encodes the V0 subunit c. Alternative splicing results in transcript variants. Pseudogenes have been identified on chromosomes 6 and 17. [provided by RefSeq, Nov 2010]

ATP6V0C Products(2)

mRNA Protein Name
NM_001198569.2 NP_001185498.1 V-type proton ATPase 16 kDa proteolipid subunit c
NM_001694.4 NP_001685.1 V-type proton ATPase 16 kDa proteolipid subunit c
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
1334459 GOA
enables ubiquitin protein ligase binding IPI
IPI: Inferred from physical interaction
18298843 GOA
Biological Process GO Annotation Evidence Reference Source
involved in positive regulation of Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
20093472 GOA
Cellular Component GO Annotation Evidence Reference Source
located in membrane IDA
IDA: Inferred from direct assay
33065002 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ATP6V0C Protein Structure

ATP-synt_C

ATP-synt_C: ATP synthase subunit C (14 - 78)

ATP-synt_C

ATP-synt_C: ATP synthase subunit C (92 - 154)

  • 0
  • 100
  • 155 a.a.
Protein Preferred Names Protein Names

V-type proton ATPase 16 kDa proteolipid subunit c

ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c

ATP6V0C Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra ATP6V0C P27449 RETREG3 Homo sapiens Q86VR2
Anti Tag CoIP
33961781
Intra ATP6V0C P27449 RETREG3 Homo sapiens Q86VR2
Y2H Prey Pooling
32296183
Intra ATP6V0C P27449 RETREG3 Homo sapiens Q86VR2
Validated Y2H
32296183
Intra ATP6V0C P27449 RETREG3 Homo sapiens Q86VR2
Y2H Array
32296183
Intra ATP6V0C P27449 NIPAL3 Homo sapiens Q6P499
Validated Y2H
32296183
Intra ATP6V0C P27449 IL10RA Homo sapiens Q13651
Y2H Array
32296183
Intra ATP6V0C P27449 IL10RA Homo sapiens Q13651
Y2H Prey Pooling
32296183
Intra ATP6V0C P27449 IL10RA Homo sapiens Q13651
Validated Y2H
32296183
Intra ATP6V0C P27449 CERS2 Homo sapiens Q96G23
Anti Tag CoIP
33961781
Intra ATP6V0C P27449 LRRC25 Homo sapiens Q8N386
Validated Y2H
32296183
Intra ATP6V0C P27449 LRRC25 Homo sapiens Q8N386
Y2H Prey Pooling
32296183
Intra ATP6V0C P27449 LRRC25 Homo sapiens Q8N386
Y2H Array
32296183
Intra ATP6V0C P27449 CLEC2D Homo sapiens Q9UHP7-3
Validated Y2H
32296183
Intra ATP6V0C P27449 CLEC2D Homo sapiens Q9UHP7-3
Y2H Prey Pooling
32296183
Intra ATP6V0C P27449 CLEC2D Homo sapiens Q9UHP7-3
Y2H Array
32296183
Intra ATP6V0C P27449 CLEC17A Homo sapiens Q6ZS10
Y2H Array
32296183
Intra ATP6V0C P27449 CLEC17A Homo sapiens Q6ZS10
Y2H Prey Pooling
32296183
Intra ATP6V0C P27449 CLEC17A Homo sapiens Q6ZS10
Validated Y2H
32296183
Intra ATP6V0C P27449 STOM Homo sapiens P27105
Y2H Array
32296183
Intra ATP6V0C P27449 STOM Homo sapiens P27105
Y2H Prey Pooling
32296183
Intra ATP6V0C P27449 FNDC9 Homo sapiens Q8TBE3
Y2H Array
32296183
Intra ATP6V0C P27449 FNDC9 Homo sapiens Q8TBE3
Validated Y2H
32296183
Intra ATP6V0C P27449 FNDC9 Homo sapiens Q8TBE3
Y2H Prey Pooling
32296183
Intra ATP6V0C P27449 OPRM1 Homo sapiens P35372-10
Validated Y2H
32296183
Intra ATP6V0C P27449 OPRM1 Homo sapiens P35372-10
Y2H Array
32296183
Intra ATP6V0C P27449 OPRM1 Homo sapiens P35372-10
Y2H Prey Pooling
32296183
Intra ATP6V0C P27449 ASGR2 Homo sapiens P07307-3
Y2H Prey Pooling
32296183
Intra ATP6V0C P27449 ASGR2 Homo sapiens P07307-3
Y2H Array
32296183
Intra ATP6V0C P27449 PI16 Homo sapiens Q6UXB8
Validated Y2H
32296183
Intra ATP6V0C P27449 PI16 Homo sapiens Q6UXB8
Y2H Prey Pooling
32296183
Intra ATP6V0C P27449 PI16 Homo sapiens Q6UXB8
Y2H Array
32296183
Intra ATP6V0C P27449 AQP6 Homo sapiens Q13520
Y2H Prey Pooling
32296183
Intra ATP6V0C P27449 AQP6 Homo sapiens Q13520
Validated Y2H
32296183
Intra ATP6V0C P27449 AQP6 Homo sapiens Q13520
Y2H Array
32296183
Intra ATP6V0C P27449 GPR152 Homo sapiens Q8TDT2
Validated Y2H
32296183
Intra ATP6V0C P27449 GPR152 Homo sapiens Q8TDT2
Y2H Array
32296183
Intra ATP6V0C P27449 GPR152 Homo sapiens Q8TDT2
Y2H Prey Pooling
32296183
Intra ATP6V0C P27449 SLC35E3 Homo sapiens Q7Z769
Validated Y2H
32296183
Intra ATP6V0C P27449 SLC35E3 Homo sapiens Q7Z769
Y2H Prey Pooling
32296183
Intra ATP6V0C P27449 SLC35E3 Homo sapiens Q7Z769
Y2H Array
32296183
Intra ATP6V0C P27449 PDCD1LG2 Homo sapiens Q9BQ51
Validated Y2H
32296183
Intra ATP6V0C P27449 PDCD1LG2 Homo sapiens Q9BQ51
Y2H Array
32296183
Intra ATP6V0C P27449 PDCD1LG2 Homo sapiens Q9BQ51
Y2H Prey Pooling
32296183
Intra ATP6V0C P27449 SCN3B Homo sapiens Q9NY72
Validated Y2H
32296183
Intra ATP6V0C P27449 SCN3B Homo sapiens Q9NY72
Y2H Prey Pooling
32296183
Intra ATP6V0C P27449 SCN3B Homo sapiens Q9NY72
Y2H Array
32296183
Intra ATP6V0C P27449 SSMEM1 Homo sapiens Q8WWF3
Y2H Prey Pooling
32296183
Intra ATP6V0C P27449 SSMEM1 Homo sapiens Q8WWF3
Validated Y2H
32296183
Intra ATP6V0C P27449 SSMEM1 Homo sapiens Q8WWF3
Y2H Array
32296183
Intra ATP6V0C P27449 SPACA1 Homo sapiens Q9HBV2
Y2H Array
32296183
Intra ATP6V0C P27449 SPACA1 Homo sapiens Q9HBV2
Y2H Prey Pooling
32296183
Intra ATP6V0C P27449 SPACA1 Homo sapiens Q9HBV2
Validated Y2H
32296183
Intra ATP6V0C P27449 CLEC14A Homo sapiens Q86T13
Y2H Prey Pooling
32296183
Intra ATP6V0C P27449 CLEC14A Homo sapiens Q86T13
Validated Y2H
32296183
Intra ATP6V0C P27449 CLEC14A Homo sapiens Q86T13
Y2H Array
32296183
Intra ATP6V0C P27449 MSR1 Homo sapiens P21757
Y2H Prey Pooling
25416956
Intra ATP6V0C P27449 MSR1 Homo sapiens P21757
Validated Y2H
25416956
Intra ATP6V0C P27449 MSR1 Homo sapiens P21757
Y2H Prey Pooling
32296183
Intra ATP6V0C P27449 MSR1 Homo sapiens P21757
Y2H Array
25416956
Intra ATP6V0C P27449 MSR1 Homo sapiens P21757
Y2H Array
32296183
Intra ATP6V0C P27449 CPLX4 Homo sapiens Q7Z7G2
Validated Y2H
32296183
Intra ATP6V0C P27449 CPLX4 Homo sapiens Q7Z7G2
Y2H Array
32296183
Intra ATP6V0C P27449 CPLX4 Homo sapiens Q7Z7G2
Y2H Prey Pooling
32296183
Intra ATP6V0C P27449 HSD17B13 Homo sapiens Q7Z5P4
Validated Y2H
32296183
Intra ATP6V0C P27449 HSD17B13 Homo sapiens Q7Z5P4
Y2H Prey Pooling
32296183
Intra ATP6V0C P27449 HSD17B13 Homo sapiens Q7Z5P4
Y2H Array
32296183
Intra ATP6V0C P27449 GPR42 Homo sapiens O15529
Y2H Prey Pooling
32296183
Intra ATP6V0C P27449 GPR42 Homo sapiens O15529
Y2H Array
32296183
Intra ATP6V0C P27449 SUSD3 Homo sapiens Q96L08
Y2H Prey Pooling
32296183
Intra ATP6V0C P27449 SUSD3 Homo sapiens Q96L08
Y2H Array
32296183
Intra ATP6V0C P27449 SUSD3 Homo sapiens Q96L08
Validated Y2H
32296183
Intra ATP6V0C P27449 FAM210B Homo sapiens Q96KR6
Y2H Prey Pooling
32296183
Intra ATP6V0C P27449 FAM210B Homo sapiens Q96KR6
Validated Y2H
32296183
Intra ATP6V0C P27449 FAM210B Homo sapiens Q96KR6
Y2H Array
32296183
Intra ATP6V0C P27449 KLK6 Homo sapiens Q92876
Y2H Pooling
32814053
Intra ATP6V0C P27449 KLK6 Homo sapiens Q92876
Validated Y2H
32814053
Intra ATP6V0C P27449 KLK6 Homo sapiens Q92876
Y2H Array
32814053
Intra ATP6V0C P27449 MCEMP1 Homo sapiens Q8IX19
Y2H Prey Pooling
32296183
Intra ATP6V0C P27449 MCEMP1 Homo sapiens Q8IX19
Validated Y2H
32296183
Intra ATP6V0C P27449 MCEMP1 Homo sapiens Q8IX19
Y2H Array
32296183
Intra ATP6V0C P27449 FFAR2 Homo sapiens O15552
Y2H Prey Pooling
32296183
Intra ATP6V0C P27449 FFAR2 Homo sapiens O15552
Y2H Array
32296183
Intra ATP6V0C P27449 CD69 Homo sapiens Q07108
Y2H Prey Pooling
32296183
Intra ATP6V0C P27449 CD69 Homo sapiens Q07108
Validated Y2H
32296183
Intra ATP6V0C P27449 CD69 Homo sapiens Q07108
Y2H Array
32296183
Intra ATP6V0C P27449 EVI2A Homo sapiens P22794
Y2H Array
32296183
Intra ATP6V0C P27449 EVI2A Homo sapiens P22794
Y2H Prey Pooling
32296183
Intra ATP6V0C P27449 DNAJC1 Homo sapiens Q96KC8
Y2H Prey Pooling
32296183
Intra ATP6V0C P27449 DNAJC1 Homo sapiens Q96KC8
Y2H Array
32296183
Intra ATP6V0C P27449 DNAJC1 Homo sapiens Q96KC8
Validated Y2H
32296183
Intra ATP6V0C P27449 PSMA3 Homo sapiens P25788
Y2H Prey Pooling
25416956
Intra ATP6V0C P27449 PSMA3 Homo sapiens P25788
Validated Y2H
25416956
Intra ATP6V0C P27449 SLC7A1 Homo sapiens P30825
Validated Y2H
32296183
Intra ATP6V0C P27449 SLC7A1 Homo sapiens P30825
Y2H Prey Pooling
32296183
Intra ATP6V0C P27449 SLC7A1 Homo sapiens P30825
Y2H Array
32296183
Intra ATP6V0C P27449 DIABLO Homo sapiens Q9NR28
Validated Y2H
32296183
Intra ATP6V0C P27449 DIABLO Homo sapiens Q9NR28
Y2H Prey Pooling
32296183
Intra ATP6V0C P27449 DIABLO Homo sapiens Q9NR28
Y2H Array
32296183
Intra ATP6V0C P27449 EDA2R Homo sapiens Q9HAV5
Validated Y2H
32296183
Intra ATP6V0C P27449 EDA2R Homo sapiens Q9HAV5
Y2H Array
32296183
Intra ATP6V0C P27449 EDA2R Homo sapiens Q9HAV5
Y2H Prey Pooling
32296183
Intra ATP6V0C P27449 EDA Homo sapiens Q92838
Y2H Prey Pooling
25416956
Intra ATP6V0C P27449 EDA Homo sapiens Q92838
Y2H Array
31515488
Intra ATP6V0C P27449 EDA Homo sapiens Q92838
Validated Y2H
25416956
Intra ATP6V0C P27449 CD53 Homo sapiens P19397
Y2H Prey Pooling
32296183
Intra ATP6V0C P27449 CD53 Homo sapiens P19397
Y2H Array
32296183
Cross ATP6V0C P27449 E5 Bovine papillomavirus P0CK45
CoIP
1334459
Intra ATP6V0C P27449 ERH Homo sapiens P84090
Validated Y2H
32296183
Intra ATP6V0C P27449 TMEM139 Homo sapiens Q8IV31
Y2H Array
32296183
Intra ATP6V0C P27449 TMEM139 Homo sapiens Q8IV31
Y2H Prey Pooling
32296183
Intra ATP6V0C P27449 TMEM139 Homo sapiens Q8IV31
Validated Y2H
32296183
Intra ATP6V0C P27449 TMEM9 Homo sapiens Q9P0T7
Validated Y2H
32296183
Intra ATP6V0C P27449 TMEM9 Homo sapiens Q9P0T7
Y2H Array
32296183
Intra ATP6V0C P27449 TMEM9 Homo sapiens Q9P0T7
Y2H Prey Pooling
32296183
Intra ATP6V0C P27449 SMIM3 Homo sapiens Q9BZL3
Validated Y2H
32296183
Intra ATP6V0C P27449 SMIM3 Homo sapiens Q9BZL3
Validated Y2H
25416956
Intra ATP6V0C P27449 SMIM3 Homo sapiens Q9BZL3
Y2H Prey Pooling
32296183
Intra ATP6V0C P27449 SMIM3 Homo sapiens Q9BZL3
Y2H Array
32296183
Intra ATP6V0C P27449 VSIR Homo sapiens Q9H7M9
Y2H Array
32296183
Intra ATP6V0C P27449 VSIR Homo sapiens Q9H7M9
Validated Y2H
32296183
Intra ATP6V0C P27449 VSIR Homo sapiens Q9H7M9
Y2H Prey Pooling
32296183
Intra ATP6V0C P27449 ZCCHC12 Homo sapiens Q6PEW1
Y2H Prey Pooling
32296183
Intra ATP6V0C P27449 ZCCHC12 Homo sapiens Q6PEW1
Validated Y2H
32296183
Intra ATP6V0C P27449 ZCCHC12 Homo sapiens Q6PEW1
Y2H Array
32296183
Intra ATP6V0C P27449 REEP4 Homo sapiens Q9H6H4
Validated Y2H
32296183
Intra ATP6V0C P27449 REEP4 Homo sapiens Q9H6H4
Y2H Array
32296183
Intra ATP6V0C P27449 REEP4 Homo sapiens Q9H6H4
Y2H Prey Pooling
32296183
Intra ATP6V0C P27449 CD79A Homo sapiens P11912
Y2H Array
32296183
Intra ATP6V0C P27449 CD79A Homo sapiens P11912
Y2H Prey Pooling
32296183
Intra ATP6V0C P27449 ERGIC3 Homo sapiens Q9Y282
Validated Y2H
32296183
Intra ATP6V0C P27449 ERGIC3 Homo sapiens Q9Y282
Y2H Array
32296183
Intra ATP6V0C P27449 ERGIC3 Homo sapiens Q9Y282
Y2H Prey Pooling
32296183
Intra ATP6V0C P27449 IL7R Homo sapiens P16871
Y2H Prey Pooling
32296183
Intra ATP6V0C P27449 IL7R Homo sapiens P16871
Y2H Array
32296183
Intra ATP6V0C P27449 KLRC1 Homo sapiens P26715
Y2H Array
32296183
Intra ATP6V0C P27449 KLRC1 Homo sapiens P26715
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Apperceptive Agnosia
Prosopagnosia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS01220 ATP6V0C Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus ATP6V0C MGD MGI:88116
Canis familiaris ATP6V0C VGNC VGNC:38272
Bos taurus ATP6V0C VGNC VGNC:26311
Rattus norvegicus ATP6V0C RGD RGD:621394