1. Gene
  2. CENPH - centromere protein H Gene

CENPH - centromere protein H Gene

Homo sapiens
Gene ID: 64946 | Gene type: protein coding

About CENPH

Cytogenetic location: 5q13.2 Genomic coordinates (GRCh38): 5:69,189,583-69,210,357 (from NCBI)

This gene has 6 transcripts (splice variants) and 170 orthologues. Broad expression in testis (RPKM 14.9), bone marrow (RPKM 9.5) and 20 other tissues.

Summary

Centromere and kinetochore proteins play a critical role in centromere structure, kinetochore formation, and sister chromatid separation. The protein encoded by this gene colocalizes with inner kinetochore plate proteins CENP-A and CENP-C in both interphase and metaphase. It localizes outside of centromeric heterochromatin, where CENP-B is localized, and inside the kinetochore corona, where CENP-E is localized during prometaphase. It is thought that this protein can bind to itself, as well as to CENP-A, CENP-B or CENP-C. Multimers of the protein localize constitutively to the inner kinetochore plate and play an important role in the organization and function of the active centromere-kinetochore complex. [provided by RefSeq, Jul 2008]

CENPH Products(1)

mRNA Protein Name
NM_022909.4 NP_075060.1 centromere protein H
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables kinetochore binding IDA
IDA: Inferred from direct assay
11092768 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
11092768 GOA
Cellular Component GO Annotation Evidence Reference Source
part of inner kinetochore IPI
IPI: Inferred from physical interaction
36085283 GOA
located in kinetochore IDA
IDA: Inferred from direct assay
11092768 GOA
located in kinetochore IMP
IMP: Inferred from mutant phenotype
20212317 GOA
located in nucleus IDA
IDA: Inferred from direct assay
11092768 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CENPH Protein Structure

CENP-H

CENP-H: Centromere protein H (CENP-H) (136 - 241)

  • 0
  • 100
  • 200
  • 247 a.a.
Protein Preferred Names Protein Names

centromere protein H

CENP-H

CENPH Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
CENPH Q9H3R5 ABI2 Homo sapiens Q9NYB9-2
Validated Y2H
32296183
Intra
CENPH Q9H3R5 ABI2 Homo sapiens Q9NYB9-2
Y2H Array
32296183
Intra
CENPH Q9H3R5 ABI2 Homo sapiens Q9NYB9-2
Y2H Prey Pooling
32296183
Intra
CENPH Q9H3R5 ZSCAN12 Homo sapiens O43309
Y2H Array
32296183
Intra
CENPH Q9H3R5 ZSCAN12 Homo sapiens O43309
Y2H Prey Pooling
32296183
Intra
CENPH Q9H3R5 C8orf58 Homo sapiens Q7Z758
Y2H Prey Pooling
32296183
Intra
CENPH Q9H3R5 C8orf58 Homo sapiens Q7Z758
Y2H Array
32296183
Intra
CENPH Q9H3R5 MTAP Homo sapiens Q13126
Y2H Prey Pooling
25416956
Intra
CENPH Q9H3R5 CHAT Homo sapiens P28329-3
Validated Y2H
32814053
Intra
CENPH Q9H3R5 CHAT Homo sapiens P28329-3
Y2H Array
32814053
Intra
CENPH Q9H3R5 CHAT Homo sapiens P28329-3
Y2H Pooling
32814053
Intra
CENPH Q9H3R5 RASSF4 Homo sapiens Q9H2L5
Y2H Array
32296183
Intra
CENPH Q9H3R5 RASSF4 Homo sapiens Q9H2L5
Y2H Prey Pooling
32296183
Intra
CENPH Q9H3R5 FGFR3 Homo sapiens P22607
Y2H Pooling
32814053
Intra
CENPH Q9H3R5 FGFR3 Homo sapiens P22607
Validated Y2H
32814053
Intra
CENPH Q9H3R5 FGFR3 Homo sapiens P22607
Y2H Array
32814053
Intra
CENPH Q9H3R5 HRAS Homo sapiens P01112
Y2H Pooling
32814053
Intra
CENPH Q9H3R5 HRAS Homo sapiens P01112
Validated Y2H
32814053
Intra
CENPH Q9H3R5 HRAS Homo sapiens P01112
Y2H Array
32814053
Intra
CENPH Q9H3R5 SPAG5 Homo sapiens Q96R06
Y2H Prey Pooling
32296183
Intra
CENPH Q9H3R5 SPAG5 Homo sapiens Q96R06
Y2H Array
32296183
Intra
CENPH Q9H3R5 MESD Homo sapiens Q14696
Y2H Prey Pooling
32296183
Intra
CENPH Q9H3R5 MESD Homo sapiens Q14696
Y2H Array
32296183
Intra
CENPH Q9H3R5 H2AP Homo sapiens O75409
Y2H Prey Pooling
32296183
Intra
CENPH Q9H3R5 H2AP Homo sapiens O75409
Y2H Array
32296183
Intra
CENPH Q9H3R5 CENPK Homo sapiens Q9BS16
TAP
24981860
Intra
CENPH Q9H3R5 CENPK Homo sapiens Q9BS16
Anti Tag CoIP
33961781
Intra
CENPH Q9H3R5 CENPK Homo sapiens Q9BS16
Validated Y2H
25416956
Intra
CENPH Q9H3R5 CENPK Homo sapiens Q9BS16
Y2H Prey Pooling
32296183
Intra
CENPH Q9H3R5 CENPK Homo sapiens Q9BS16
Y2H Array
25416956
Intra
CENPH Q9H3R5 CENPK Homo sapiens Q9BS16
Y2H Array
32296183
Intra
CENPH Q9H3R5 ERH Homo sapiens P84090
Y2H Prey Pooling
32296183
Intra
CENPH Q9H3R5 ERH Homo sapiens P84090
Y2H Array
32296183
Intra
CENPH Q9H3R5 DCTN2 Homo sapiens Q13561
Y2H Array
32296183
Intra
CENPH Q9H3R5 DCTN2 Homo sapiens Q13561
Y2H Prey Pooling
32296183
Intra
CENPH Q9H3R5 NDC80 Homo sapiens O14777
Y2H
15713649
Intra
CENPH Q9H3R5 NDC80 Homo sapiens O14777
Anti Tag CoIP
33961781
Intra
CENPH Q9H3R5 NDC80 Homo sapiens O14777
Y2H Prey Pooling
32296183
Intra
CENPH Q9H3R5 NDC80 Homo sapiens O14777
Y2H Array
32296183
Intra
CENPH Q9H3R5 NUP54 Homo sapiens Q7Z3B4
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Chromosome 17p13.3, Centromeric, Duplication Syndrome

Chromosome 17p13.3 Duplication Syndrome

17p13.3 Duplication Syndrome

17p13.3 Microduplication Syndrome

Trisomy 17p13.3

Chromosome 17p13.3 Centromeric Duplication Syndrome

Dup(17)(P13.3)

Crest Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Mus musculus CENPH MGD MGI:1349448
Canis familiaris CENPH VGNC VGNC:39104
Bos taurus CENPH VGNC VGNC:27177
Rattus norvegicus CENPH RGD RGD:1583506
Macaca mulatta CENPH VGNC VGNC:70964