CENPH - centromere protein H Gene

Homo sapiens

Gene ID: 64946 | Gene type: protein coding

About CENPH

Cytogenetic location: 5q13.2 Genomic coordinates (GRCh38): 5:69,189,583-69,210,357 (from NCBI)

This gene has 6 transcripts (splice variants) and 170 orthologues. Broad expression in testis (RPKM 14.9), bone marrow (RPKM 9.5) and 20 other tissues.

Summary

Centromere and kinetochore proteins play a critical role in centromere structure, kinetochore formation, and sister chromatid separation. The protein encoded by this gene colocalizes with inner kinetochore plate proteins CENP-A and CENP-C in both interphase and metaphase. It localizes outside of centromeric heterochromatin, where CENP-B is localized, and inside the kinetochore corona, where CENP-E is localized during prometaphase. It is thought that this protein can bind to itself, as well as to CENP-A, CENP-B or CENP-C. Multimers of the protein localize constitutively to the inner kinetochore plate and play an important role in the organization and function of the active centromere-kinetochore complex. [provided by RefSeq, Jul 2008]

CENPH Products(1)

mRNA	Protein	Name
NM_022909.4	NP_075060.1	centromere protein H

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables kinetochore binding	IDA IDA: Inferred from direct assay	11092768	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11092768	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of inner kinetochore	IPI IPI: Inferred from physical interaction	36085283	GOA
located in kinetochore	IDA IDA: Inferred from direct assay	11092768	GOA
located in kinetochore	IMP IMP: Inferred from mutant phenotype	20212317	GOA
located in nucleus	IDA IDA: Inferred from direct assay	11092768	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CENPH Protein Structure

CENP-H

0
100
200
247 a.a.

Protein Preferred Names

Protein Names

centromere protein H

CENP-H

CENPH Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CENPH	Q9H3R5	ABI2	Homo sapiens	Q9NYB9-2	Validated Y2H	32296183
Intra	CENPH	Q9H3R5	ABI2	Homo sapiens	Q9NYB9-2	Y2H Array	32296183
Intra	CENPH	Q9H3R5	ABI2	Homo sapiens	Q9NYB9-2	Y2H Prey Pooling	32296183
Intra	CENPH	Q9H3R5	ZSCAN12	Homo sapiens	O43309	Y2H Array	32296183
Intra	CENPH	Q9H3R5	ZSCAN12	Homo sapiens	O43309	Y2H Prey Pooling	32296183
Intra	CENPH	Q9H3R5	C8orf58	Homo sapiens	Q7Z758	Y2H Prey Pooling	32296183
Intra	CENPH	Q9H3R5	C8orf58	Homo sapiens	Q7Z758	Y2H Array	32296183
Intra	CENPH	Q9H3R5	MTAP	Homo sapiens	Q13126	Y2H Prey Pooling	25416956
Intra	CENPH	Q9H3R5	CHAT	Homo sapiens	P28329-3	Validated Y2H	32814053
Intra	CENPH	Q9H3R5	CHAT	Homo sapiens	P28329-3	Y2H Array	32814053
Intra	CENPH	Q9H3R5	CHAT	Homo sapiens	P28329-3	Y2H Pooling	32814053
Intra	CENPH	Q9H3R5	RASSF4	Homo sapiens	Q9H2L5	Y2H Array	32296183
Intra	CENPH	Q9H3R5	RASSF4	Homo sapiens	Q9H2L5	Y2H Prey Pooling	32296183
Intra	CENPH	Q9H3R5	FGFR3	Homo sapiens	P22607	Y2H Pooling	32814053
Intra	CENPH	Q9H3R5	FGFR3	Homo sapiens	P22607	Validated Y2H	32814053
Intra	CENPH	Q9H3R5	FGFR3	Homo sapiens	P22607	Y2H Array	32814053
Intra	CENPH	Q9H3R5	HRAS	Homo sapiens	P01112	Y2H Pooling	32814053
Intra	CENPH	Q9H3R5	HRAS	Homo sapiens	P01112	Validated Y2H	32814053
Intra	CENPH	Q9H3R5	HRAS	Homo sapiens	P01112	Y2H Array	32814053
Intra	CENPH	Q9H3R5	SPAG5	Homo sapiens	Q96R06	Y2H Prey Pooling	32296183
Intra	CENPH	Q9H3R5	SPAG5	Homo sapiens	Q96R06	Y2H Array	32296183
Intra	CENPH	Q9H3R5	MESD	Homo sapiens	Q14696	Y2H Prey Pooling	32296183
Intra	CENPH	Q9H3R5	MESD	Homo sapiens	Q14696	Y2H Array	32296183
Intra	CENPH	Q9H3R5	H2AP	Homo sapiens	O75409	Y2H Prey Pooling	32296183
Intra	CENPH	Q9H3R5	H2AP	Homo sapiens	O75409	Y2H Array	32296183
Intra	CENPH	Q9H3R5	CENPK	Homo sapiens	Q9BS16	TAP	24981860
Intra	CENPH	Q9H3R5	CENPK	Homo sapiens	Q9BS16	Anti Tag CoIP	33961781
Intra	CENPH	Q9H3R5	CENPK	Homo sapiens	Q9BS16	Validated Y2H	25416956
Intra	CENPH	Q9H3R5	CENPK	Homo sapiens	Q9BS16	Y2H Prey Pooling	32296183
Intra	CENPH	Q9H3R5	CENPK	Homo sapiens	Q9BS16	Y2H Array	25416956
Intra	CENPH	Q9H3R5	CENPK	Homo sapiens	Q9BS16	Y2H Array	32296183
Intra	CENPH	Q9H3R5	ERH	Homo sapiens	P84090	Y2H Prey Pooling	32296183
Intra	CENPH	Q9H3R5	ERH	Homo sapiens	P84090	Y2H Array	32296183
Intra	CENPH	Q9H3R5	DCTN2	Homo sapiens	Q13561	Y2H Array	32296183
Intra	CENPH	Q9H3R5	DCTN2	Homo sapiens	Q13561	Y2H Prey Pooling	32296183
Intra	CENPH	Q9H3R5	NDC80	Homo sapiens	O14777	Y2H	15713649
Intra	CENPH	Q9H3R5	NDC80	Homo sapiens	O14777	Anti Tag CoIP	33961781
Intra	CENPH	Q9H3R5	NDC80	Homo sapiens	O14777	Y2H Prey Pooling	32296183
Intra	CENPH	Q9H3R5	NDC80	Homo sapiens	O14777	Y2H Array	32296183
Intra	CENPH	Q9H3R5	NUP54	Homo sapiens	Q7Z3B4	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Chromosome 17p13.3, Centromeric, Duplication Syndrome

Chromosome 17p13.3 Duplication Syndrome	17p13.3 Duplication Syndrome
17p13.3 Microduplication Syndrome	Trisomy 17p13.3
Chromosome 17p13.3 Centromeric Duplication Syndrome	Dup(17)(P13.3)

Crest Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02480	CENPH Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CENPH	MGD	MGI:1349448
Canis familiaris	CENPH	VGNC	VGNC:39104
Bos taurus	CENPH	VGNC	VGNC:27177
Rattus norvegicus	CENPH	RGD	RGD:1583506
Macaca mulatta	CENPH	VGNC	VGNC:70964

Name
Email *

	Sorry, but the email address you supplied was invalid.