Map3k7 - mitogen-activated protein kinase kinase kinase 7 Gene

Mus musculus

Also known as Tak1; B430101B05

Gene ID: 26409 | Gene type: protein coding

About Map3k7

Chromosome 4: 31,964,097-32,023,467 forward strand.GRCm39:CM000997.3

This gene has 9 transcripts (splice variants), 208 orthologues, 1 paralogue and is associated with 32 phenotypes. Ubiquitous expression in CNS E11.5 (RPKM 14.7), limb E14.5 (RPKM 14.) and 28 other tissues.

Summary

Enables Enzyme activator activity; protein kinase activity; and receptor tyrosine kinase binding activity. Involved in several processes, including JNK cascade; anoikis; and negative regulation of necroptotic process. Acts upstream of or within several processes, including intracellular signal transduction; regulation of signal transduction; and tube morphogenesis. Located in postsynaptic density. Is expressed in several structures, including central nervous system; gut; metanephros; reproductive system; and respiratory system. Used to study Wolff-Parkinson-White syndrome. Human ortholog(s) of this gene implicated in frontometaphyseal dysplasia 2 and prostate Cancer. Orthologous to human MAP3K7 (mitogen-activated protein kinase kinase kinase 7). [provided by Alliance of Genome Resources, Apr 2022]

Map3k7 Products(2)

mRNA	Protein	Name
NM_172688.3	NP_766276.1	mitogen-activated protein kinase kinase kinase 7 isoform A
NM_009316.1	NP_033342.1	mitogen-activated protein kinase kinase kinase 7 isoform B

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables MAP kinase kinase activity	IDA IDA: Inferred from direct assay	12464436	MGI
enables MAP kinase kinase kinase kinase activity	IMP IMP: Inferred from mutant phenotype	20551513	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	12556533	MGI
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	18762249	MGI
enables protein serine/threonine kinase activity	IMP IMP: Inferred from mutant phenotype	16260493	MGI
enables receptor tyrosine kinase binding	IPI IPI: Inferred from physical interaction	18762249	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within I-kappaB phosphorylation	IGI IGI: Inferred from genetic interaction	16260493	MGI
involved in JNK cascade	IDA IDA: Inferred from direct assay	29291351	MGI
acts upstream of JNK cascade	IGI IGI: Inferred from genetic interaction	16260493	MGI
acts upstream of or within MAPK cascade	IDA IDA: Inferred from direct assay	12556533	MGI
involved in MAPK cascade	IMP IMP: Inferred from mutant phenotype	20551513	MGI
acts upstream of or within angiogenesis	IMP IMP: Inferred from mutant phenotype	16556914	MGI
involved in anoikis	IMP IMP: Inferred from mutant phenotype	23778976	MGI
acts upstream of apoptotic signaling pathway	IGI IGI: Inferred from genetic interaction	16260493	MGI
acts upstream of apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	16260493	MGI
involved in bone development	IMP IMP: Inferred from mutant phenotype	20551513	MGI
acts upstream of or within negative regulation of apoptotic signaling pathway	IGI IGI: Inferred from genetic interaction	16260493	MGI
acts upstream of or within negative regulation of apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	16260493	MGI
involved in negative regulation of necroptotic process	IMP IMP: Inferred from mutant phenotype	21052097	MGI
involved in negative regulation of reactive oxygen species metabolic process	IMP IMP: Inferred from mutant phenotype	21052097	MGI
acts upstream of or within negative regulation of ripoptosome assembly involved in necroptotic process	IGI IGI: Inferred from genetic interaction	21052097	MGI
acts upstream of or within neural tube formation	IMP IMP: Inferred from mutant phenotype	16260493	MGI
involved in osteoblast differentiation	IMP IMP: Inferred from mutant phenotype	20551513	MGI
acts upstream of or within positive regulation of JNK cascade	IGI IGI: Inferred from genetic interaction	16260493	MGI
involved in positive regulation of canonical NF-kappaB signal transduction	IGI IGI: Inferred from genetic interaction	16260493	MGI
involved in positive regulation of macroautophagy	IMP IMP: Inferred from mutant phenotype	23778976	MGI
acts upstream of or within protein phosphorylation	IDA IDA: Inferred from direct assay	12464436	MGI
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	28842570	MGI
acts upstream of or within regulation of reactive oxygen species metabolic process	IMP IMP: Inferred from mutant phenotype	21052097	MGI
acts upstream of or within transforming growth factor beta receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	16145668	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in postsynaptic density	IDA IDA: Inferred from direct assay	17114649	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Map3k7 Protein Structure

STKc_TAK1

0
100
200
300
400
500
579 a.a.

Protein Preferred Names

Protein Names

mitogen-activated protein kinase kinase kinase 7

TGF-beta-activated kinase 1

transforming growth factor-beta-activated kinase 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-136848	SM1-71	Inhibitor	96.09%	Unkown
HY-RS08062	MAP3K7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS08063	Map3k7 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS08064	MAP3K7 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS08065	MAP3K7CL Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Map3k7	NCBI	NCBI:6885

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