MAP3K7 - mitogen-activated protein kinase kinase kinase 7 Gene

Homo sapiens

Also known as CSCF; FMD2; TAK1; MEKK7; TGF1a

Gene ID: 6885 | Gene type: protein coding

About MAP3K7

Cytogenetic location: 6q15 Genomic coordinates (GRCh38): 6:90,513,579-90,587,072 (from NCBI)

This gene has 24 transcripts (splice variants), 208 orthologues, 2 paralogues and is associated with 5 phenotypes. Ubiquitous expression in thyroid (RPKM 10.0), endometrium (RPKM 9.4) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and Apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

MAP3K7 Products(5)

mRNA	Protein	Name
NM_003188.4	NP_003179.1	mitogen-activated protein kinase kinase kinase 7 isoform A
NM_145332.3	NP_663305.1	mitogen-activated protein kinase kinase kinase 7 isoform C
XM_006715553.4	XP_006715616.1	mitogen-activated protein kinase kinase kinase 7 isoform X1
NM_145333.3	NP_663306.1	mitogen-activated protein kinase kinase kinase 7 isoform D
NM_145331.3	NP_663304.1	mitogen-activated protein kinase kinase kinase 7 isoform B

MAP3K7 Protein Structure

Pkinase_Tyr

0
100
200
300
400
500
606 a.a.

Protein Preferred Names

Protein Names

mitogen-activated protein kinase kinase kinase 7

TGF-beta activated kinase 1

transforming growth factor-beta-activated kinase 1

MAP3K7 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	MAP3K7	O43318	N	SARS-CoV-2	P0DTC9	Anti Tag CoIP	33895773
Intra	MAP3K7	O43318	CDC37	Homo sapiens	Q16543	Pull Down	32707033
Intra	MAP3K7	O43318	CDC37	Homo sapiens	Q16543	Anti Tag CoIP	31980649
Intra	MAP3K7	O43318	UBC	Homo sapiens	P0CG48	Anti Tag CoIP	19820695
Intra	MAP3K7	O43318	TAB1	Homo sapiens	Q15750	Anti Tag CoIP	35271311
Intra	MAP3K7	O43318	TAB1	Homo sapiens	Q15750	Y2H	22158122
Intra	MAP3K7	O43318	TAB1	Homo sapiens	Q15750	Anti Bait CoIP	22158122
Intra	MAP3K7	O43318	TAB1	Homo sapiens	Q15750	PLA	25241761
Intra	MAP3K7	O43318	TAB1	Homo sapiens	Q15750	Pull Down	32707033
Intra	MAP3K7	O43318	TAB2	Homo sapiens	Q9NYJ8	Pull Down	32707033
Intra	MAP3K7	O43318	TAB2	Homo sapiens	Q9NYJ8	Anti Bait CoIP	22081109
Intra	MAP3K7	O43318	TAB2	Homo sapiens	Q9NYJ8	Anti Bait CoIP	16845370
Intra	MAP3K7	O43318	TAB2	Homo sapiens	Q9NYJ8	Anti Tag CoIP	35271311
Intra	MAP3K7	O43318	TAB2	Homo sapiens	Q9NYJ8	Anti Bait CoIP	17158449
Intra	MAP3K7	O43318	TAB2	Homo sapiens	Q9NYJ8	Anti Bait CoIP	22158122
Intra	MAP3K7	O43318	TRAF6	Homo sapiens	Q9Y4K3	Anti Tag CoIP	19820695
Intra	MAP3K7	O43318	PPP6C	Homo sapiens	O00743	Phosphatase Assay	17079228
Intra	MAP3K7	O43318	PPP6C	Homo sapiens	O00743	Anti Tag CoIP	17079228
Intra	MAP3K7	O43318	TAB3	Homo sapiens	Q8N5C8	Pull Down	32707033
Intra	MAP3K7	O43318	TAB3	Homo sapiens	Q8N5C8	Anti Tag CoIP	35271311
Intra	MAP3K7	O43318	MAP2K7	Homo sapiens	O14733	Anti Tag CoIP	17110930
Intra	MAP3K7	O43318	MAP2K7	Homo sapiens	O14733	GMS	17709393
Intra	MAP3K7	O43318	STAT3	Homo sapiens	P40763	Anti Bait CoIP	15764709
Intra	MAP3K7	O43318	MAPK8IP1	Homo sapiens	Q9UQF2	Anti Bait CoIP	17709393
Intra	MAP3K7	O43318	MAPK8IP1	Homo sapiens	Q9UQF2	Pull Down	16840345
Intra	MAP3K7	O43318	IKBKB	Homo sapiens	O14920	Confocal	33895773
Intra	MAP3K7	O43318	IKBKB	Homo sapiens	O14920	Anti Tag CoIP	33895773
Cross	MAP3K7	O43318	cagA	Helicobacter pylori	B5Z6S0	Pull Down	19820695
Cross	MAP3K7	O43318	cagA	Helicobacter pylori	B5Z6S0	Anti Tag CoIP	19820695

Cross: Cross-species interaction Intra: Intraspecies interaction

MAP3K7 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80858	Phospho-TAK1 (Ser439) Antibody	WB, ICC/IF, IP	Human, Mouse, Rat
HY-P80908	TAK1 Antibody (YA663)	WB	Human, Mouse, Rat, Monkey

Related Diseases

Diseases

Alias

Noonan Syndrome 1

Noonan Syndrome	NS1
Male Turner Syndrome	Female Pseudo-Turner Syndrome
Turner Phenotype With Normal Karyotype	Noonan Syndrome With Pigmented Villonodular Synovitis
Turner'S Phenotype, Karyotype Normal	Familial Turner Syndrome
Noonan'S Syndrome	Noonan-Ehmke Syndrome
Ns	Pseudo-Ullrich-Turner Syndrome
Turner Syndrome In Female With X Chromosome	Turner-Like Syndrome
Ullrich-Noonan Syndrome	Noonan-Like/Multiple Giant Cell Lesion Syndrome
Noonan Syndrome-Like Disorder With Multiple Giant Cell Lesions	Pterygium Colli Syndrome
Noonan Syndrome, Type 1	Turner Syndrome, Male

Otopalatodigital Syndrome Spectrum Disorder

Opd Spectrum Disorder	Opsd
Fronto-Otopalatodigital Osteodysplasia

Frontometaphyseal Dysplasia 2

FMD2

Ectodermal Dysplasia

Congenital Ectodermal Defect	Congenital Ectodermal Dysplasia
Ectodermal Dysplasia Syndrome	Dysplasia, Ectodermal

Synostosis

Brachydactyly

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Hepatomas
Liver Neoplasm	Liver Carcinoma
Liver And Intrahepatic Biliary Tract Carcinoma	Malignant Hepatobiliary Neoplasm
Adult Primary Hepatocellular Carcinoma	Hepatoblastoma
Carcinoma Of Liver	Malignant Liver Tumour
Malignant Hepatic Tumour

Cardiospondylocarpofacial Syndrome

Mitral Regurgitation, Conductive Deafness, And Fusion Of Cervical Vertebrae And Of Carpal And Tarsal Bones	Forney Robinson Pascoe Syndrome
CSCF	Mitral Regurgitation, Conductive Deafness, And Fusion Of Cervical Vertebrae And
Congenital Heart Disease, Deafness, And Skeletal Malformations	Forney Syndrome
Forney-Robinson-Pascoe Syndrome	Mitral Regurgitation-Deafness-Skeletal Anomalies Syndrome
Mitral Regurgitation-Hearing Loss-Skeletal Anomalies Syndrome

Frontometaphyseal Dysplasia

Fmd	Dysplasia, Frontometaphyseal

Hyperostosis

Hypertrophy Of Bone	Bone Hypertrophy
Bone Thickening	Periosteum Thickening

Non-Syndromic X-Linked Intellectual Disability 91

Mrx91

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-136848	SM1-71	Inhibitor	96.09%	Unkown
HY-RS08062	MAP3K7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS08063	Map3k7 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS08064	MAP3K7 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS08065	MAP3K7CL Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	MAP3K7	MGD	MGI:1346877
Rattus norvegicus	MAP3K7	RGD	RGD:1309438
Bos taurus	MAP3K7	VGNC	VGNC:31200
Macaca mulatta	MAP3K7	VGNC	VGNC:74497
Canis familiaris	MAP3K7	VGNC	VGNC:42977
Felis catus	MAP3K7	VGNC	VGNC:68161
Others	MAP3K7	NCBI

Name
Email *

	Sorry, but the email address you supplied was invalid.