Pik3cg - phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma Gene

Rattus norvegicus

Also known as Pi3k

Gene ID: 298947 | Gene type: protein coding

About Pik3cg

Primary_assembly 6: 48,766,864-48,802,043 reverse strand.mRatBN7.2:CM026979.1

This gene has 2 transcripts (splice variants), 215 orthologues, 9 paralogues and is associated with 40 phenotypes. Biased expression in Thymus (RPKM 145.7), Spleen (RPKM 18.5) and 8 other tissues.

Summary

Enables 1-phosphatidylinositol-3-kinase activity. Involved in several processes, including hepatocyte apoptotic process; negative regulation of triglyceride catabolic process; and phosphatidylinositol phosphate biosynthetic process. Part of phosphatidylinositol 3-kinase complex. Used to study liver cirrhosis. Biomarker of diabetic retinopathy. Human ortholog(s) of this gene implicated in autistic disorder and swine influenza. Orthologous to human PIK3CG (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma). [provided by Alliance of Genome Resources, Apr 2022]

Pik3cg Products(1)

mRNA	Protein	Name
NM_001371300.2	NP_001358229.1	phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables 1-phosphatidylinositol-3-kinase activity	IDA IDA: Inferred from direct assay	12882977	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in hepatocyte apoptotic process	IMP IMP: Inferred from mutant phenotype	20675006	RGD
involved in negative regulation of triglyceride catabolic process	IMP IMP: Inferred from mutant phenotype	21435395	RGD
involved in phosphatidylinositol phosphate biosynthetic process	IDA IDA: Inferred from direct assay	12882977	RGD
involved in positive regulation of acute inflammatory response	IMP IMP: Inferred from mutant phenotype	17526805	RGD
involved in positive regulation of cytosolic calcium ion concentration	IMP IMP: Inferred from mutant phenotype	11266463	RGD
involved in secretory granule localization	IMP IMP: Inferred from mutant phenotype	19549714	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
part of phosphatidylinositol 3-kinase complex	IDA IDA: Inferred from direct assay	12882977	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Pik3cg Protein Structure

PIK3CG_ABD

PI3K_rbd

C2_PI3K_class_I_gamma

PI3Ka_I

PI3Kc_IB_gamma

0
200
400
600
800
1000
1102 a.a.

Protein Preferred Names

Protein Names

phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

phosphoinositide-3-kinase, catalytic, gamma polypeptide

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-163677	ARM165	Inhibitor	99.75%	Unkown
HY-RS10532	PIK3CG Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS10533	Pik3cg Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS10534	Pik3cg Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pik3cg	NCBI	NCBI:5294

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