2. PROTAC PI3K/Akt/mTOR
  3. PROTACs PI3K Akt
  4. ARM165

ARM165 is a heterobifunctional molecule. ARM165 degrades the PIK3CG proteins, inhibits PI3Kγ-Akt signaling pathway, and thus exhibits antileukemia efficacy. ARM165 inhibits proliferations of AML cells, with IC50 <1 μM. (Pink: ligand for target protein PI3Kγ inhibitor AZ2 (HY-111570); Black: linker; Blue: ligand for E3 ligase Pomalidomide (HY-10984))

For research use only. We do not sell to patients.

ARM165 Chemical Structure

ARM165 Chemical Structure

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Based on 1 publication(s) in Google Scholar

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Description

ARM165 is a heterobifunctional molecule. ARM165 degrades the PIK3CG proteins, inhibits PI3Kγ-Akt signaling pathway, and thus exhibits antileukemia efficacy. ARM165 inhibits proliferations of AML cells, with IC50 <1 μM. (Pink: ligand for target protein PI3Kγ inhibitor AZ2 (HY-111570); Black: linker; Blue: ligand for E3 ligase Pomalidomide (HY-10984))[1]

Molecular Weight

837.98

Formula

C44H51N7O8S
Appearance

Solid

Color

White to off-white

SMILES

CC1=C2C(N(CC2=CC(C3=C(N=C(S3)NC(CCCC(NCCCCCCCC(NC4=CC=CC5=C4C(N(C5=O)C6CCC(NC6=O)=O)=O)=O)=O)=O)C)=C1)[C@H](C7CC7)C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 28.57 mg/mL (34.09 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1933 mL 5.9667 mL 11.9335 mL
5 mM 0.2387 mL 1.1933 mL 2.3867 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.1933 mL 5.9667 mL 11.9335 mL 29.8336 mL
5 mM 0.2387 mL 1.1933 mL 2.3867 mL 5.9667 mL
10 mM 0.1193 mL 0.5967 mL 1.1933 mL 2.9834 mL
15 mM 0.0796 mL 0.3978 mL 0.7956 mL 1.9889 mL
20 mM 0.0597 mL 0.2983 mL 0.5967 mL 1.4917 mL
25 mM 0.0477 mL 0.2387 mL 0.4773 mL 1.1933 mL
30 mM 0.0398 mL 0.1989 mL 0.3978 mL 0.9945 mL
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ARM165 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ARM165ARM 165ARM-165PROTACsPI3KAktPhosphoinositide 3-kinasePKBProtein kinase BAMLacute myeloid leukemiavenetoclaxantileukemiaU937KG1αHL60OCI-AML3OCI-AML2MOLM-14MV4-11MCF7HCT116HT29NOMO-1Inhibitorinhibitorinhibit

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