2. Gene
  3. DDX56 - DEAD-box helicase 56 Gene

DDX56 - DEAD-box helicase 56 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as DDX21; DDX26; NOH61

Gene ID: 54606 | Gene type: protein coding

About DDX56

Cytogenetic location: 7p13 Genomic coordinates (GRCh38): 7:44,565,804-44,573,908 (from NCBI)

This gene has 12 transcripts (splice variants), 195 orthologues and 38 paralogues. Ubiquitous expression in thyroid (RPKM 15.8), lymph node (RPKM 15.1) and 25 other tissues.

Summary

This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene shows ATPase activity in the presence of polynucleotides and associates with nucleoplasmic 65S preribosomal particles. This gene may be involved in ribosome synthesis, most likely during assembly of the large 60S ribosomal subunit. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012]

DDX56 Products(2)

mRNA Protein Name
NM_001257189.2 NP_001244118.1 probable ATP-dependent RNA helicase DDX56 isoform 2
NM_019082.4 NP_061955.1 probable ATP-dependent RNA helicase DDX56 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables RNA stem-loop binding IDA
IDA: Inferred from direct assay
33109765 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables protein sequestering activity IDA
IDA: Inferred from direct assay
31340999 GOA
Biological Process GO Annotation Evidence Reference Source
involved in defense response to virus IDA
IDA: Inferred from direct assay
33109765 GOA
acts upstream of negative effect modulation by host of viral RNA genome replication IMP
IMP: Inferred from mutant phenotype
33109765 GOA
involved in negative regulation of type I interferon production IDA
IDA: Inferred from direct assay
31340999 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytosol IDA
IDA: Inferred from direct assay
33109765 GOA
located in nucleolus IDA
IDA: Inferred from direct assay
33109765 GOA
is active in nucleus IDA
IDA: Inferred from direct assay
31340999 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DDX56 Protein Structure

DEAD

DEAD: DEAD/DEAH box helicase (31 - 206)

Helicase_C

Helicase_C: Helicase conserved C-terminal domain (276 - 319)

Helicase_C

Helicase_C: Helicase conserved C-terminal domain (344 - 380)

  • 0
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  • 400
  • 500
  • 547 a.a.
Protein Preferred Names Protein Names

probable ATP-dependent RNA helicase DDX56

61-kd nucleolar helicase

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03661 DDX56 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus DDX56 VGNC VGNC:27978
Rattus norvegicus DDX56 RGD RGD:1303195
Canis familiaris DDX56 VGNC VGNC:39866
Mus musculus DDX56 MGD MGI:1277172
Felis catus DDX56 VGNC VGNC:61417