CRLS1 - cardiolipin synthase 1 Gene

Homo sapiens

Also known as CLS; CLS1; GCD10; C20orf155; dJ967N21.6

Gene ID: 54675 | Gene type: protein coding

About CRLS1

Cytogenetic location: 20p12.3 Genomic coordinates (GRCh38): 20:6,005,938-6,040,053 (from NCBI)

This gene has 7 transcripts (splice variants), 197 orthologues and 1 paralogue. Ubiquitous expression in liver (RPKM 13.5), lung (RPKM 13.1) and 25 other tissues.

Summary

This gene encodes a member of the CDP-alcohol phosphatidyltransferase class-I family of proteins. The encoded Enzyme catalyzes the synthesis of cardiolipin, a phospholipid component of mitochondrial membranes that is critical for mitochondrial function. [provided by RefSeq, Apr 2016]

CRLS1 Products(6)

mRNA	Protein	Name
NM_001127458.2	NP_001120930.1	cardiolipin synthase (CMP-forming) isoform 2
NM_001323561.2	NP_001310490.1	cardiolipin synthase (CMP-forming) isoform 3
NM_001323562.2	NP_001310491.1	cardiolipin synthase (CMP-forming) isoform 3
NM_001323563.2	NP_001310492.1	cardiolipin synthase (CMP-forming) isoform 3
NM_001323564.2	NP_001310493.1	cardiolipin synthase (CMP-forming) isoform 3
NM_019095.6	NP_061968.1	cardiolipin synthase (CMP-forming) isoform 1

CRLS1 Protein Structure

CDP-OH_P_transf

0
100
200
301 a.a.

Protein Preferred Names

Protein Names

cardiolipin synthase (CMP-forming)

Related Diseases

Diseases

Alias

Barth Syndrome

3-Methylglutaconic Aciduria Type 2	BTHS
Cardioskeletal Myopathy With Neutropenia And Abnormal Mitochondria	Mga Type Ii
Mga2	Mgca2
Mga Type 2	3-Methylglutaconic Aciduria Type Ii
3-Methylglutaconic Aciduria, Type Ii	Mga, Type Ii
3-Methylglutaconicaciduria Type 2	3-Methylglutaconicaciduria Type Ii
Taz Defect	3 Methylglutaconic Aciduria, Type Ii
Dnajc19 Defect	Cardioskeletal Myopathy-Neutropenia Syndrome
X-Linked Cardioskeletal Myopathy And Neutropenia	3-Alpha-Methylglutaconic Aciduria Type 2
Agm2	Cardioskeletal Myopathy-Neutropenia
Invm	Left Ventricular Non-Compaction Isolated X-Linked
Non-Compaction Of Left Ventricular Myocardium Isolated X-Linked	Agammaglobulinemia 2, Autosomal Recessive

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03189	CRLS1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CRLS1	VGNC	VGNC:27719
Macaca mulatta	CRLS1	VGNC	VGNC:71419
Rattus norvegicus	CRLS1	RGD	RGD:1311037
Canis familiaris	CRLS1	VGNC	VGNC:39623
Mus musculus	CRLS1	MGD	MGI:1913836
Felis catus	CRLS1	VGNC	VGNC:61185

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