IL26 - interleukin 26 Gene

Homo sapiens

Also known as AK155; IL-26

Gene ID: 55801 | Gene type: protein coding

About IL26

Cytogenetic location: 12q15 Genomic coordinates (GRCh38): 12:68,201,349-68,225,810 (from NCBI)

This gene has 1 transcript (splice variant), 70 orthologues and 4 paralogues. Low expression observed in reference dataset.

Summary

This gene was identified by its overexpression specifically in herpesvirus samimiri-transformed T cells. The encoded protein is a member of the IL10 family of cytokines. It is a secreted protein and may function as a homodimer. This protein is thought to contribute to the transformed phenotype of T cells after Infection by herpesvirus samimiri. [provided by RefSeq, Jul 2008]

IL26 Products(1)

mRNA	Protein	Name
NM_018402.2	NP_060872.1	interleukin-26 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables cytokine activity	IDA IDA: Inferred from direct assay	18483078	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of epithelial cell proliferation	IDA IDA: Inferred from direct assay	18483078	GOA
involved in positive regulation of ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	18483078	GOA
involved in positive regulation of cytokine production	IDA IDA: Inferred from direct assay	18483078	GOA
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA IDA: Inferred from direct assay	18483078	GOA
involved in positive regulation of receptor signaling pathway via JAK-STAT	IDA IDA: Inferred from direct assay	18483078	GOA
involved in positive regulation of stress-activated MAPK cascade	IDA IDA: Inferred from direct assay	18483078	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	18483078	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosol	IDA IDA: Inferred from direct assay	18483078	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	18483078	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IL26 Protein Structure

IL10

0
100
171 a.a.

Protein Preferred Names

Protein Names

interleukin-26

Recombinant IL26 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P700117AF	Animal-Free IL-26/AK155 Protein, Human (His)	Q9NPH9 (K22-Q171)	≥95%

Related Diseases

Diseases

Alias

Crohn'S Disease

Crohn Disease	Pediatric Crohn'S Disease
Regional Enteritis	Crohn'S Disease Of Large Bowel
Granulomatous Colitis	Enteritis, Granulomatous
Enteritis	Crohn'S Disease Of Colon
Colitis, Granulomatous	Crohn'S Enteritis
Enteritis, Regional	Ileitis
Adenoviral Enteritis	Acute Gastroenteropathy Due To Norwalk Agent
Viral Gastroenteritis Due To Norwalk Agent	Winter Vomiting
Epidemic Winter Vomiting Disease	Small Round Structured Virus Enteritis
Epidemic Vomiting Syndrome	Epidemic Vomiting
Epidemic Nausea	Epidemic Viral Gastroenteritis Due To Norwalk Virus
Noroviral Enteritis	Crohn Disease Nos
Crohns	Cd - [Crohn'S Disease]
Regional Enteritis Of Bowel	Crohn'S Regional Enteritis
Cobble-Stone Appearance Of Intestine	Intestinal Ulcer And Erosion Due To Crohn Disease
Granulomatous Enteritis

Hidradenitis Suppurativa

Acne Inversa	Suppurative Hidradenitis
Acne Inversa, Familial	Apocrinitis
Hidradenitides, Suppurative	Hidradenitis, Suppurative
Suppurative Hidradenitides	Inverse Acne

Hidradenitis

Hydradenitis

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Psoriasis 12

PSORS12	Psoriasis Susceptibility 12
Psoriasis 12, Susceptibility To

Rheumatoid Arthritis

RA	Arthritis, Rheumatoid
Rheumatoid Arthritis, Susceptibility To	Arthritis Or Polyarthritis, Rheumatic
Atrophic Arthritis	Rheumatism Arthritis
Rheumatoid Polyarthritis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06745	IL26 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

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