Ehmt1 - euchromatic histone methyltransferase 1 Gene

Mus musculus

Also known as GLP; GLP1; KMT1D; mKIAA1876; D330003E03; Eu-HMTase1; 9230102N17Rik

Gene ID: 77683 | Gene type: protein coding

About Ehmt1

Chromosome 2: 24,679,940-24,809,626 reverse strand.GRCm39:CM000995.3

This gene has 18 transcripts (splice variants), 314 orthologues, 20 paralogues and is associated with 82 phenotypes. Ubiquitous expression in CNS E11.5 (RPKM 26.6), whole brain E14.5 (RPKM 23.) and 28 other tissues.

Summary

Enables C2H2 zinc finger domain binding activity; Histone Methyltransferase activity (H3-K27 specific); and Histone Methyltransferase activity (H3-K9 specific). Involved in several processes, including macromolecule methylation; negative regulation of transcription, DNA-templated; and positive regulation of cold-induced thermogenesis. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including alimentary system; forelimb; integumental system; nervous system; and respiratory system. Used to study Kleefstra syndrome 1. Human ortholog(s) of this gene implicated in Kleefstra syndrome and Kleefstra syndrome 1. Orthologous to human EHMT1 (euchromatic histone lysine methyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]

Ehmt1 Products(4)

mRNA	Protein	Name
NM_001012518.3	NP_001012536.2	histone-lysine N-methyltransferase EHMT1 isoform 1
NM_001109687.2	NP_001103157.1	histone-lysine N-methyltransferase EHMT1 isoform 4
NM_001109686.2	NP_001103156.1	histone-lysine N-methyltransferase EHMT1 isoform 3
NM_172545.4	NP_766133.2	histone-lysine N-methyltransferase EHMT1 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables C2H2 zinc finger domain binding	IPI IPI: Inferred from physical interaction	16702210	MGI
enables histone H3K27 methyltransferase activity	IDA IDA: Inferred from direct assay	15774718	MGI
enables histone H3K9 methyltransferase activity	IDA IDA: Inferred from direct assay	15774718	MGI
enables histone H3K9 methyltransferase activity	IMP IMP: Inferred from mutant phenotype	18818694	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	15774718	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA methylation-dependent heterochromatin formation	IDA IDA: Inferred from direct assay	18818694	MGI
involved in facultative heterochromatin formation	IDA IDA: Inferred from direct assay	19010785	MGI
involved in negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	21131967	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	17392792	MGI
involved in peptidyl-lysine dimethylation	IMP IMP: Inferred from mutant phenotype	15774718	MGI
involved in peptidyl-lysine monomethylation	IMP IMP: Inferred from mutant phenotype	15774718	MGI
involved in positive regulation of cold-induced thermogenesis	IMP IMP: Inferred from mutant phenotype	24196706	MGI
involved in regulation of embryonic development	IMP IMP: Inferred from mutant phenotype	15774718	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	15774718	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ehmt1 Protein Structure

EHMT_ZBD

PHA03095

ANK

Ank_2

ANK

SET_EHMT1

0
200
400
600
800
1000
1200
1289 a.a.

Protein Preferred Names

Protein Names

histone-lysine N-methyltransferase EHMT1

G9a-like protein 1	euchromatic histone-lysine N-methyltransferase 1
lysine N-methyltransferase 1D

Related Agents

Pre-clinical Phase

Bioactive Molecules (11)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15273	UNC0638		98.60%	Unkown
HY-12583	A-366	Inhibitor	98.01%	Unkown
HY-13808	UNC 0631	Inhibitor	98.35%	Unkown
HY-13807	UNC0646	Inhibitor	99.38%	Unkown
HY-111904	EHMT2-IN-2	Inhibitor	≥99.0%	Unkown
HY-111778	EHMT2-IN-1	Inhibitor	99.85%	Unkown
HY-148817	WDR5-0102	Inhibitor	97.02%	Unkown
HY-RS04227	EHMT1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS04228	Ehmt1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS04229	EHMT1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-110093	UNC0638 hydrate	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ehmt1	NCBI	NCBI:79813

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