PLCZ1 - phospholipase C zeta 1 Gene

Homo sapiens

Also known as SPGF17; PLCzeta; NYD-SP27; PLC-zeta-1

Gene ID: 89869 | Gene type: protein coding

About PLCZ1

Cytogenetic location: 12p12.3 Genomic coordinates (GRCh38): 12:18,645,609-18,738,012 (from NCBI)

This gene has 20 transcripts (splice variants), 203 orthologues, 14 paralogues and is associated with 1 phenotype. Restricted expression toward testis (RPKM 5.9).

Summary

The protein encoded by this gene is a member of the phosphoinositide-specific Phospholipase C family. Members in this family, classified into six isotypes that are tissue- and organ-specific, hydrolyze phosphatidylinositol 4,5-bisphosphate just before the phosphate group to yield diacylglycerol and inositol 1,4,5-trisphosphate. This protein localizes to the acrosome in spermatozoa and elicits CA(2+) oscillations and egg activation during fertilization that leads to early embryonic development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

PLCZ1 Products(3)

mRNA	Protein	Name
NM_001330769.1	NP_001317698.1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform 3
NM_001330774.2	NP_001317703.1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform 2
NM_033123.4	NP_149114.2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform 1

PLCZ1 Protein Structure

EF-hand_like

PI-PLC-X

PI-PLC-Y

0
100
200
300
400
500
608 a.a.

Protein Preferred Names

Protein Names

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1

PI-phospholipase C zeta 1

Related Diseases

Diseases

Alias

Spermatogenic Failure 17

SPGF17

Male Infertility Due To Oocyte Activation Failure

Spermatogenic Failure 9

Male Infertility Due To Globozoospermia	SPGF9
Male Infertility Due To Round-Headed Spermatozoa	Globozoospermia, Complete
Globozoospermia, Total	Globozoospermia
Globozoospermia Syndrome	Round-Headed Sperm Syndrome
Globozoospermia Complete	Globozoospermia Total

Infertility

Varicocele

Scrotal Varices	Varicoceles
Varicocele Of Scrotum	Scrotal Varicocele

Spermatogenic Failure

Azoospermia	Spgf
Spermatogenic Failure, Susceptibility To	Absent Sperm
Aspermatogenesis	Infertility Due To Azoospermia
Hypospermatogenesis	Azoospermatism

Cystic Fibrosis

Mucoviscidosis	CF
Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis	Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis
Cystic Fibrosis Lung Disease, Modifier Of	Cystic Fibrosis Of Pancreas
Fibrocystic Disease Of Pancreas	Cf - [Cystic Fibrosis]
Cystic Fibrosis Nos	Fibrocystic Disease
Fibrocystic Disease Of The Pancreas	Mucoviscidosis Of Pancreas
Nonproliferative Fibrocystic Disease	Pancreatic Cystic Fibrosis

Warburg Micro Syndrome 1

Warburg Micro Syndrome	Micro Syndrome
Warbm	WARBM1
Warburg Sjo Fledelius Syndrome	Warburg-Sjo-Fledelius Syndrome
Micro Syndrome 1	Microcephaly, Microcornea, Congenital Cataract, Intellectual Disability, Optic Atrophy And Hypogenitalism

Oligoasthenoteratozoospermia

Oat	Oligoasthenoteratospermia

Male Infertility

Infertility, Male	Infertility Male
Male Sterility	Absolute Infertility

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10669	PLCZ1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PLCZ1	RGD	RGD:1359567
Macaca mulatta	PLCZ1	VGNC	VGNC:76070
Felis catus	PLCZ1	VGNC	VGNC:64212
Canis familiaris	PLCZ1	VGNC	VGNC:44659
Mus musculus	PLCZ1	MGD	MGI:2150308
Bos taurus	PLCZ1	VGNC	VGNC:32995

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