2. Others Metabolic Enzyme/Protease Membrane Transporter/Ion Channel Neuronal Signaling
  3. Isotope-Labeled Compounds Endogenous Metabolite iGluR
  4. Glycine-d2

Glycine-d2 is the deuterium labeled Glycine. Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors.

For research use only. We do not sell to patients.

Glycine-d<sub>2</sub> Chemical Structure

Glycine-d2 Chemical Structure

CAS No. : 4896-75-7

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Based on 1 publication(s) in Google Scholar

Other Forms of Glycine-d2:

Glycine-d2 Related Antibodies

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Description

Glycine-d2 is the deuterium labeled Glycine. Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors.

IC50 & Target

NMDA Receptor

 

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Glycine-d2 Related Antibodies
Molecular Weight

77.08

Formula

C2H3D2NO2
CAS No.
Unlabeled CAS

56-40-6
Appearance

Solid

Color

White to off-white

SMILES

NC([2H])([2H])C(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 125 mg/mL (1621.69 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 12.9735 mL 64.8677 mL 129.7353 mL
5 mM 2.5947 mL 12.9735 mL 25.9471 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥99.0%

COA (248 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 12.9735 mL 64.8677 mL 129.7353 mL 324.3383 mL
5 mM 2.5947 mL 12.9735 mL 25.9471 mL 64.8677 mL
10 mM 1.2974 mL 6.4868 mL 12.9735 mL 32.4338 mL
15 mM 0.8649 mL 4.3245 mL 8.6490 mL 21.6226 mL
20 mM 0.6487 mL 3.2434 mL 6.4868 mL 16.2169 mL
25 mM 0.5189 mL 2.5947 mL 5.1894 mL 12.9735 mL
30 mM 0.4325 mL 2.1623 mL 4.3245 mL 10.8113 mL
40 mM 0.3243 mL 1.6217 mL 3.2434 mL 8.1085 mL
50 mM 0.2595 mL 1.2974 mL 2.5947 mL 6.4868 mL
60 mM 0.2162 mL 1.0811 mL 2.1623 mL 5.4056 mL
80 mM 0.1622 mL 0.8108 mL 1.6217 mL 4.0542 mL
100 mM 0.1297 mL 0.6487 mL 1.2974 mL 3.2434 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Glycine-d2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Glycine-d24896-75-7Isotope-Labeled CompoundsEndogenous MetaboliteiGluRIonotropic glutamate receptorsInhibitorinhibitorinhibit

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