2. Antibody-drug Conjugate/ADC Related
  3. ADC Linker
  4. MC-Ala-Ala-PAB

MC-Ala-Ala-PAB is a cleavable ADC linker. Fmoc-Ala-Ala-PAB can be used in the synthesis of antibody-drug conjugates (ADCs).

For research use only. We do not sell to patients.

MC-Ala-Ala-PAB Chemical Structure

MC-Ala-Ala-PAB Chemical Structure

CAS No. : 1949793-44-5

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5 mg USD 38 In-stock
10 mg USD 60 In-stock
25 mg USD 125 In-stock
50 mg USD 200 In-stock
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Based on 1 publication(s) in Google Scholar

MC-Ala-Ala-PAB Related Antibodies

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Description

MC-Ala-Ala-PAB is a cleavable ADC linker. Fmoc-Ala-Ala-PAB can be used in the synthesis of antibody-drug conjugates (ADCs)[1].

IC50 & Target[1]

Cleavable Linker

 

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MC-Ala-Ala-PAB Related Antibodies
Molecular Weight

458.51

Formula

C23H30N4O6
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

OCC(C=C1)=CC=C1NC([C@H](C)NC([C@H](C)NC(CCCCCN2C(C=CC2=O)=O)=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 20.83 mg/mL (45.43 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1810 mL 10.9049 mL 21.8098 mL
5 mM 0.4362 mL 2.1810 mL 4.3620 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

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Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1810 mL 10.9049 mL 21.8098 mL 54.5244 mL
5 mM 0.4362 mL 2.1810 mL 4.3620 mL 10.9049 mL
10 mM 0.2181 mL 1.0905 mL 2.1810 mL 5.4524 mL
15 mM 0.1454 mL 0.7270 mL 1.4540 mL 3.6350 mL
20 mM 0.1090 mL 0.5452 mL 1.0905 mL 2.7262 mL
25 mM 0.0872 mL 0.4362 mL 0.8724 mL 2.1810 mL
30 mM 0.0727 mL 0.3635 mL 0.7270 mL 1.8175 mL
40 mM 0.0545 mL 0.2726 mL 0.5452 mL 1.3631 mL
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MC-Ala-Ala-PAB Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MC-Ala-Ala-PAB1949793-44-5ADC LinkerAntibody-drug conjugates linkerADC linkercleavableInhibitorinhibitorinhibit

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