Mc-Phe-Lys-PAB-MMAE

Cat. No.: HY-131451: FAQs
Data Sheet SDS Handling Instructions

Molarity Calculator

Mc-Phe-Lys-PAB-MMAE (Compound 2) is a drug-linker conjugate for ADC, and can be used for synthesis of ADCs.

For research use only. We do not sell to patients.

Mc-Phe-Lys-PAB-MMAE Chemical Structure

CAS No. : 646502-54-7

Size	Price	Stock
1 mg	USD 456	Ask For Quote & Lead Time
5 mg	USD 961	Ask For Quote & Lead Time
10 mg	USD 1538	Ask For Quote & Lead Time

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This product is a controlled substance and not for sale in your territory.

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•Related Small Molecules:

•Related Proteins:

View All Drug-Linker Conjugates for ADC Isoform Specific Products:

View All Isoforms

Auristatin Camptothecins Daunorubicins/Doxorubicins Duocarmycins Maytansinoids Pyrrolobenzodiazepines Traditional Cytotoxic Agents

Biological Activity
Purity & Documentation
References
Customer Review

Description

Mc-Phe-Lys-PAB-MMAE (Compound 2) is a drug-linker conjugate for ADC, and can be used for synthesis of ADCs^[1].

Molecular Weight

1335.67

Formula

C₇₂H₁₀₆N₁₀O₁₄

CAS No.

646502-54-7

Appearance

Solid

Color

White to off-white

SMILES

CN([C@@H]([C@@H](C)CC)[C@H](OC)CC(N1[C@H]([C@H](OC)[C@@H](C)C(N[C@H](C)[C@@H](O)C2=CC=CC=C2)=O)CCC1)=O)C([C@H](C(C)C)NC([C@H](C(C)C)N(C(OCC3=CC=C(NC([C@H](CCCCN)NC([C@H](CC4=CC=CC=C4)NC(CCCCCN5C(C=CC5=O)=O)=O)=O)=O)C=C3)=O)C)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture and light

*The compound is unstable in solutions, freshly prepared is recommended.

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL (74.87 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.7487 mL	3.7434 mL	7.4869 mL
5 mM	0.1497 mL	0.7487 mL	1.4974 mL
10 mM	0.0749 mL	0.3743 mL	0.7487 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Working solution concentration: mg/mL

Purity & Documentation

Data Sheet (269 KB) SDS (252 KB) Handling Instructions (2659 KB)

References

[1]. Doronina SO, et al. Development of potent monoclonal antibody auristatin conjugates for cancer therapy. Nat Biotechnol. 2003 Jul;21(7):778-84. [Content Brief]

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	0.7487 mL	3.7434 mL	7.4869 mL	18.7172 mL
	5 mM	0.1497 mL	0.7487 mL	1.4974 mL	3.7434 mL
	10 mM	0.0749 mL	0.3743 mL	0.7487 mL	1.8717 mL
	15 mM	0.0499 mL	0.2496 mL	0.4991 mL	1.2478 mL
	20 mM	0.0374 mL	0.1872 mL	0.3743 mL	0.9359 mL
	25 mM	0.0299 mL	0.1497 mL	0.2995 mL	0.7487 mL
	30 mM	0.0250 mL	0.1248 mL	0.2496 mL	0.6239 mL
	40 mM	0.0187 mL	0.0936 mL	0.1872 mL	0.4679 mL
	50 mM	0.0150 mL	0.0749 mL	0.1497 mL	0.3743 mL
	60 mM	0.0125 mL	0.0624 mL	0.1248 mL	0.3120 mL