2. Academic Validation
  3. Translational Research in Culture: AADAC, Diabetes, and Cardiovascular Disease

Translational Research in Culture: AADAC, Diabetes, and Cardiovascular Disease

  • Cell Stem Cell. 2020 Jul 2;27(1):6-7. doi: 10.1016/j.stem.2020.06.012.
Ashish Misra 1,  Edward A Fisher 2
Affiliations

Affiliations

  • 1 Heart Research Institute, Sydney, NSW, Australia; Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia. Electronic address: ashish.misra@hri.org.au.
  • 2 Department of Medicine/Divsion of Cardiology, and the Cardiovascular Research Center, New York University Grossman School of Medicine, New York, NY, USA. Electronic address: edward.fisher@nyulangone.org.
PMID: 32619519 DOI: 10.1016/j.stem.2020.06.012
Abstract

Many type 2 diabetes patients develop Cardiovascular Disease (CVD) while some are protected. Toyohara et al. (2020) find that elevated arylacetamide deacetylase (AADAC) expression in vascular smooth muscle cells (dVSMCs) differentiated from patient-derived induced pluripotent stem cells is associated with cardioprotection. AADAC overexpression alters multiple dVSMC properties and decreases murine CVD.

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