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  3. Neurological disorders after severe pneumonia are associated with translocation of endogenous bacteria from the lung to the brain

Neurological disorders after severe pneumonia are associated with translocation of endogenous bacteria from the lung to the brain

  • Sci Adv. 2023 Oct 20;9(42):eadi0699. doi: 10.1126/sciadv.adi0699.
Qingle Ma 1,  Chenlu Yao 1,  Yi Wu 1,  Heng Wang 1,  Qin Fan 2,  Qianyu Yang 1,  Jialu Xu 1,  Huaxing Dai 1,  Yue Zhang 1,  Fang Xu 1,  Ting Lu 3,  Jennifer K Dowling 4,  Chao Wang 1
Affiliations

Affiliations

  • 1 Laboratory for Biomaterial and Immunoengineering, Institute of Functional Nano & Soft Materials (FUNSOM), Soochow University, Suzhou 215123, China.
  • 2 Jiangsu Key Laboratory for Biosensors, Institute of Advanced Materials (IAM) and School of Materials Science and Engineering, Nanjing University of Posts & Telecommunications, Nanjing, P. R. China.
  • 3 Institute of Pharmacology, Laboratory of Aging and Nervous Diseases, Jiangsu Key Laboratory of Neuropsychiatric Disease, College of Pharmaceutical Sciences, Soochow University, Suzhou 215123, China.
  • 4 School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland, University of Medical and Health Sciences, Dublin, Ireland.
PMID: 37851811 DOI: 10.1126/sciadv.adi0699
Abstract

Neurological disorders are a common feature in patients who recover from severe acute pneumonia. However, the underlying mechanisms remain poorly understood. Here, we show that the neurological syndromes after severe acute pneumonia are partly attributed to the translocation of endogenous bacteria from the lung to the brain during pneumonia. Using principal components analysis, similarities were found between the brain's flora species and those of the lungs, indicating that the bacteria detected in the brain may originate from the lungs. We also observed impairment of both the lung-blood and brain-blood barriers, allowing endogenous lung bacteria to invade the brain during pneumonia. An elevated microglia and astrocyte activation signature via Bacterial infection-related pathways was observed, indicating a bacterial-induced disruption of brain homeostasis. Collectively, we identify endogenous lung bacteria that play a role in altering brain homeostasis, which provides insight into the mechanism of neurological syndromes after severe pneumonia.

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