2. Antibody-drug Conjugate/ADC Related
  3. ADC Cytotoxin
  4. MMAF-OtBu

MMAF-OtBu (Example 2) is a modified MMAF (HY-15579 ). MMAF-OtBu can be used for synthesis of ADCs.

For research use only. We do not sell to patients.

MMAF-OtBu Chemical Structure

MMAF-OtBu Chemical Structure

CAS No. : 745017-95-2

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Based on 1 publication(s) in Google Scholar

MMAF-OtBu Related Antibodies

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Description

MMAF-OtBu (Example 2) is a modified MMAF (HY-15579 ). MMAF-OtBu can be used for synthesis of ADCs[1].

Molecular Weight

788.07

Formula

C43H73N5O8
CAS No.
Appearance

Solid

SMILES

CC(C)(C)OC([C@H](CC1=CC=CC=C1)NC([C@H](C)[C@H]([C@@]2([H])N(CCC2)C(C[C@@H](OC)[C@H]([C@@H](C)CC)N(C)C([C@H](C(C)C)NC([C@@H](NC)C(C)C)=O)=O)=O)OC)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (63.45 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2689 mL 6.3446 mL 12.6892 mL
5 mM 0.2538 mL 1.2689 mL 2.5378 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.2689 mL 6.3446 mL 12.6892 mL 31.7231 mL
5 mM 0.2538 mL 1.2689 mL 2.5378 mL 6.3446 mL
10 mM 0.1269 mL 0.6345 mL 1.2689 mL 3.1723 mL
15 mM 0.0846 mL 0.4230 mL 0.8459 mL 2.1149 mL
20 mM 0.0634 mL 0.3172 mL 0.6345 mL 1.5862 mL
25 mM 0.0508 mL 0.2538 mL 0.5076 mL 1.2689 mL
30 mM 0.0423 mL 0.2115 mL 0.4230 mL 1.0574 mL
40 mM 0.0317 mL 0.1586 mL 0.3172 mL 0.7931 mL
50 mM 0.0254 mL 0.1269 mL 0.2538 mL 0.6345 mL
60 mM 0.0211 mL 0.1057 mL 0.2115 mL 0.5287 mL
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MMAF-OtBu Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MMAF-OtBu745017-95-2ADC CytotoxinADC PayloadADCMMAFInhibitorinhibitorinhibit

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HY-156225
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