2. Signaling Pathways
  3. Antibody-drug Conjugate/ADC Related
  4. ADC Cytotoxin
  5. Pyrrolobenzodiazepines Isoform

Pyrrolobenzodiazepines

Calicheamicins, Duocarymycins and PBD dimers are all different types of DNA-damaging agents that are functionally similar to anthracyclines in that they all target the minor groove of DNA. The DNA double helix forms two grooves which are present as a result of the geometric conformation of the two antiparallel strands. The minor groove is narrower and consists of fewer exposed base pairs in comparison with the major groove. Calicheamicins bind the minor grooves of tumour cell DNA where it forms reactive diradical species that ultimately cause cleavage of the DNA strands at various locations. Duocarmycins and PBD dimers take effect in similar ways with the former acting as a DNA minor groove alkylating agent and the latter as a minor groove cross-linker. As with any normal tissue, damage to the DNA of a cancer cell induces cell death via apoptosis.

Pyrrolobenzodiazepines Related Products (8):

Cat. No. Product Name Effect Purity
  • HY-101161
    SG3199
    		98.94%
    SG3199 is a cytotoxic DNA minor groove interstrand crosslinking pyrrolobenzodiazepine (PBD) dimer. SG3199 is the released warhead component of the ADC payload Tesirine (SG3249).
  • HY-14573
    SJG-136
    		99.47%
    SJG-136 is a DNA cross-linking agent, with an XL50 of 45 nM for pBR322 DNA. SJG-136 has potent antitumor activity.
  • HY-101160
    SG2057
    SG2057 (DRG16) is a PBD dimer containing a pentyldioxy linkage which binds sequence selectively in the minor groove of DNA forming DNA interstrand and intrastrand cross-linked adducts. SG2057 is a highly active antitumor agent.
  • HY-117371
    Hemiasterlin
    		99.77%
    Hemiasterlin ((-)-Hemiasterlin) is an antimitotic marine natural product with potent anticancer effcts. Hemiasterlin can be used as a cytotoxic payload (ADC Cytotoxin) in antibody-drug conjugates (ADCs).
  • HY-102001
    Tomaymycin DM
    		98.01%
    Tomaymycin DM, a DNA alkylator, is a derivative of Tomaymycin, it is a PBD dimer, which is attached to tumor targeting antibodies to create antibody-drug conjugates (ADCs).
  • HY-126678
    Dimethyl-SGD-1882
    Dimethyl-SGD-1882 (Dimethyl-PBD dimer) is a highly potent DNA alkylator, and is used as an antibody-drug conjugate (ADC) cytotoxin. PBD Dimer is a DNA alkylator which inhibits DNA replication.
  • HY-135900
    Aniline-MPB-amino-C3-PBD
    Aniline-MPB-amino-C3-PBD is a cytotoxic agent comprised non-alkylating group. Aniline-MPB-amino-C3-PBD is a sequence-selective DNA minor-groove binding agent. Aniline-MPB-amino-C3-PBD acts as the payload for ADCs. Antimicrobial activity.
  • HY-135901
    Py-MPB-amino-C3-PBD
    Py-MPB-amino-C3-PBD is a cytotoxic agent comprised non-alkylating group. Py-MPB-amino-C3-PBD acts as the payload for ADCs. Antimicrobial activity.